Alec Leonetti
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View article: High prevalence and emerging positive association of kelch13 R622I and HRP2-based RDT negativity in Plasmodium falciparum in northern Ethiopia
High prevalence and emerging positive association of kelch13 R622I and HRP2-based RDT negativity in Plasmodium falciparum in northern Ethiopia Open
The rise of antimalarial drug-resistant Plasmodium falciparum threatens malaria elimination efforts. Mutations in the gene kelch13 ( k13 ) confer artemisinin partial resistance (ART-R), compromising the efficacy of frontline artemisinin-ba…
View article: COATswga: A Coverage Optimizing and Accurate Toolkit for fast primer design in selective whole genome amplification
COATswga: A Coverage Optimizing and Accurate Toolkit for fast primer design in selective whole genome amplification Open
Background Despite the transformative nature of next-generation sequencing in genomics, efficiently capturing underrepresented microbial DNA from complex biological mixtures, such as pathogens from host samples, remains a persistent challe…
View article: Clonal Transmission of Emerging Novel <i>Plasmodium falciparum</i> Kelch13 Mutations and Increasing Complexity of Infection in Libreville, Gabon, 2021-2023
Clonal Transmission of Emerging Novel <i>Plasmodium falciparum</i> Kelch13 Mutations and Increasing Complexity of Infection in Libreville, Gabon, 2021-2023 Open
Artemisinin partial resistance (ART-R) in Plasmodium falciparum , due to mutations in the Kelch13 (K13) propeller domain, is spreading across Africa. However, data from Central Africa remain sparse. This study performed molecular surveilla…
View article: Rising prevalence of Plasmodium falciparum Artemisinin partial resistance mutations in Ethiopia
Rising prevalence of Plasmodium falciparum Artemisinin partial resistance mutations in Ethiopia Open
The increasing prevalence of k13 R622I and the emergence of additional ART-R mutations underscore the urgent need for enhanced ACT efficacy monitoring. Early detection of partner drug resistance and ACT failure will be essential to address…
View article: Artemisinin resistant<i>kelch13</i>R622I and RDT negativity approaching predominance in northern Ethiopia and emerging C580Y of African origin threaten falciparum malaria control
Artemisinin resistant<i>kelch13</i>R622I and RDT negativity approaching predominance in northern Ethiopia and emerging C580Y of African origin threaten falciparum malaria control Open
The rise of antimalarial drug-resistant Plasmodium falciparum poses a major threat to malaria treatment, control, and elimination efforts. Mutations in the kelch13 ( k13 ) gene confer artemisinin partial resistance (ART-R), compromising th…
View article: Comparison of nanopore with illumina whole genome assemblies of the Epstein-Barr virus in Burkitt lymphoma
Comparison of nanopore with illumina whole genome assemblies of the Epstein-Barr virus in Burkitt lymphoma Open
Endemic Burkitt lymphoma (eBL) is one of the most prevalent cancer in children in sub-Saharan Africa, and while prior studies have found that Epstein-Barr virus (EBV) type and variation may alter the tumor driver genes necessary for tumor …
View article: Comparison of Nanopore with Illumina Whole Genome Assemblies of the Epstein-Barr Virus in Burkitt Lymphoma
Comparison of Nanopore with Illumina Whole Genome Assemblies of the Epstein-Barr Virus in Burkitt Lymphoma Open
Endemic Burkitt lymphoma (eBL) is one of the most prevalent cancer in children in sub-Saharan Africa, and while prior studies have found that Epstein-Barr virus (EBV) type and variation may alter the tumor driver genes necessary for tumor …
View article: Leukocyte depletion in dried blood spot cards enables enrichment of parasite DNA for improved sequencing
Leukocyte depletion in dried blood spot cards enables enrichment of parasite DNA for improved sequencing Open
Expanding access to simple blood collection tools is essential to monitor, control, and eliminate malaria in low resource settings where the disease is endemic. The most common method to preserve blood is depositing fingerstick samples ont…
View article: High frequency of artemisinin partial resistance mutations in the Great Lakes region revealed through rapid pooled deep sequencing
High frequency of artemisinin partial resistance mutations in the Great Lakes region revealed through rapid pooled deep sequencing Open
BACKGROUND: In Africa, the first Plasmodium falciparum artemisinin partial resistance mutation, was Kelch13 (K13) 561H - detected and validated at appreciable frequency in Rwanda in 2014. Surveillance to better define the extent of the eme…
View article: High Frequency of Artemisinin Partial Resistance Mutations in the Great Lakes Region Revealed Through Rapid Pooled Deep Sequencing
High Frequency of Artemisinin Partial Resistance Mutations in the Great Lakes Region Revealed Through Rapid Pooled Deep Sequencing Open
Background In Africa, the first Plasmodium falciparum artemisinin partial resistance mutation was Kelch13 (K13) 561H, detected and validated at appreciable frequency in Rwanda in 2014. Surveillance to better define the extent of the emerge…
View article: High frequency of artemisinin partial resistance mutations in the great lake region revealed through rapid pooled deep sequencing
High frequency of artemisinin partial resistance mutations in the great lake region revealed through rapid pooled deep sequencing Open
In Africa, the first Plasmodium falciparum Kelch13 (K13) artemisinin partial resistance mutation 561H was first detected and validated in Rwanda. Surveillance to better define the extent of the emergence in Rwanda and neighboring countries…