Andrew J. Andrews
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View article: Evaluating a Targeted Language Intervention for Children Aged 4–6 Years—Applying an ‘Information Carrying Words’ Approach
Evaluating a Targeted Language Intervention for Children Aged 4–6 Years—Applying an ‘Information Carrying Words’ Approach Open
Background Very little research has investigated the use of the information carrying words (ICW) construct within language interventions, despite its very widespread use in speech and language therapy in the United Kingdom. The Language En…
View article: 1061 CLSP-1025, a novel bispecific T-cell engager targeting a p53 R175H mutant peptide presented by HLA-A*02:01
1061 CLSP-1025, a novel bispecific T-cell engager targeting a p53 R175H mutant peptide presented by HLA-A*02:01 Open
View article: Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis
Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis Open
The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear-cytoplasmic compartment are citrate and acetate, which are pro…
View article: Supplementary Figures S1-S2 and Supplementary Tables S1-S3 from Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non–Small Cell Lung Cancer Cells
Supplementary Figures S1-S2 and Supplementary Tables S1-S3 from Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non–Small Cell Lung Cancer Cells Open
Supplementary Table S1: Proteins upregulated follwoing vemurafenib treatment of SK-MEL-28VR1 cells. Supplementary Figure S1: PHGDH gene ablation of SK-MEL-28VR1 cells. Supplementary Figure S2: Gemcitabine induced sensitization of SK-MEL-28…
View article: Data from Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non–Small Cell Lung Cancer Cells
Data from Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non–Small Cell Lung Cancer Cells Open
Metastatic melanoma cells commonly acquire resistance to BRAF V600E inhibitors (BRAFi). In this study, we identified serine biosynthesis as a critical mechanism of resistance. Proteomic assays revealed differential protein expressio…
View article: Supplementary Figures S1-S2 and Supplementary Tables S1-S3 from Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non–Small Cell Lung Cancer Cells
Supplementary Figures S1-S2 and Supplementary Tables S1-S3 from Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non–Small Cell Lung Cancer Cells Open
Supplementary Table S1: Proteins upregulated follwoing vemurafenib treatment of SK-MEL-28VR1 cells. Supplementary Figure S1: PHGDH gene ablation of SK-MEL-28VR1 cells. Supplementary Figure S2: Gemcitabine induced sensitization of SK-MEL-28…
View article: Data from Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non–Small Cell Lung Cancer Cells
Data from Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non–Small Cell Lung Cancer Cells Open
Metastatic melanoma cells commonly acquire resistance to BRAF V600E inhibitors (BRAFi). In this study, we identified serine biosynthesis as a critical mechanism of resistance. Proteomic assays revealed differential protein expressio…
View article: Data from An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis
Data from An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis Open
Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder characterized by the development of multiple tumors in the central nervous system, most notably schwannomas, and meningiomas. Mutational inactivation of the NF2 gene e…
View article: Figure S4 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma
Figure S4 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma Open
SmoM2 MB cells are resistant to simvastatin treatment
View article: Supplementary Materials and Methods and Supplementary Figure Legends from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer
Supplementary Materials and Methods and Supplementary Figure Legends from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer Open
Supplementary Materials and Methods and Supplementary Figure Legends
View article: Data from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer
Data from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer Open
Targeting epigenetic pathways is a promising approach for cancer therapy. Here, we report on the unexpected finding that targeting calcium signaling can reverse epigenetic silencing of tumor suppressor genes (TSG). In a screen for drugs th…
View article: Data from An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis
Data from An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis Open
Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder characterized by the development of multiple tumors in the central nervous system, most notably schwannomas, and meningiomas. Mutational inactivation of the NF2 gene e…
View article: Table S2 from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer
Table S2 from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer Open
Table S2. Drug screening results after treatment at 50 µM for 24h
View article: Data from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma
Data from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma Open
Purpose: The role of cholesterol biosynthesis in hedgehog pathway activity and progression of hedgehog pathway medulloblastoma (Hh-MB) were examined in vivo. Statins, commonly used cholesterol-lowering agents, were utilized t…
View article: Table S1 from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer
Table S1 from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer Open
Table S1. Drug screening results after treatment at 10 µM for 72h
View article: Table S2 from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer
Table S2 from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer Open
Table S2. Drug screening results after treatment at 50 µM for 24h
View article: Figure S2 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma
Figure S2 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma Open
Proliferation of MB cells does not rely on astrocyte-derived cholesterol
View article: Data from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma
Data from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma Open
Purpose: The role of cholesterol biosynthesis in hedgehog pathway activity and progression of hedgehog pathway medulloblastoma (Hh-MB) were examined in vivo. Statins, commonly used cholesterol-lowering agents, were utilized t…
View article: Figure S2 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma
Figure S2 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma Open
Proliferation of MB cells does not rely on astrocyte-derived cholesterol
View article: Supplementary Data from An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis
Supplementary Data from An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis Open
Supplemental files describing metabolic alterations in NF2-deficient cells, supplementary materials and methods, and supportive data regarding the effects of FASN inhibitors or knockdown on various metabolic processes in WT and NF2-deficie…
View article: Table S1 from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer
Table S1 from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer Open
Table S1. Drug screening results after treatment at 10 µM for 72h
View article: Supplementary Materials and Methods and Supplementary Figure Legends from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer
Supplementary Materials and Methods and Supplementary Figure Legends from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer Open
Supplementary Materials and Methods and Supplementary Figure Legends
View article: Figure S4 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma
Figure S4 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma Open
SmoM2 MB cells are resistant to simvastatin treatment
View article: Figure S3 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma
Figure S3 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma Open
Simvastatin inhibits MB cell proliferation in Ptch1+/- mice.
View article: Supplementary Data from An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis
Supplementary Data from An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis Open
Supplemental files describing metabolic alterations in NF2-deficient cells, supplementary materials and methods, and supportive data regarding the effects of FASN inhibitors or knockdown on various metabolic processes in WT and NF2-deficie…
View article: Figure S1 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma
Figure S1 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma Open
Cholesterol availability influences proliferation of Ptch1+/- MB proliferation cells
View article: Figure S1 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma
Figure S1 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma Open
Cholesterol availability influences proliferation of Ptch1+/- MB proliferation cells
View article: Supplementary figures 1 through 14 from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer
Supplementary figures 1 through 14 from Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer Open
Supplementary Figure S1. Drug screening based on the measurement of GFP fluorescence by flow cytometry. Supplementary Figure S2. Dose response curves of GFP reactivation after cardiac glycosides treatment. Supplementary Figure S3. Tumor su…
View article: Figure S3 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma
Figure S3 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma Open
Simvastatin inhibits MB cell proliferation in Ptch1+/- mice.
View article: Table S1 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma
Table S1 from Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma Open
Gene sets and pathways with selective enrichment among MB subtypes