Alexander L.E. Wang
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View article: Fc-enhanced anti-CTLA-4 depletes tumor-infiltrating regulatory T cells to augment immune effects of androgen ablation in high-risk prostate cancer
Fc-enhanced anti-CTLA-4 depletes tumor-infiltrating regulatory T cells to augment immune effects of androgen ablation in high-risk prostate cancer Open
Despite high rates of post-surgical recurrence in men with high-risk localized prostate cancer (PCa), there is currently no role for neoadjuvant therapy. Tumor infiltrating regulatory T cells (TI-Tregs) limit the antitumor effects of presu…
View article: pyVIPER: A fast and scalable Python package for rank-based enrichment analysis of single-cell RNASeq data
pyVIPER: A fast and scalable Python package for rank-based enrichment analysis of single-cell RNASeq data Open
Summary Single-cell sequencing has revolutionized biomedical research by offering insights into cellular heterogeneity at unprecedented resolution. Yet, the low signal-to-noise ratio, characteristic of single-cell RNA sequencing (scRNASeq)…
View article: A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer
A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer Open
Although localized prostate cancer is relatively indolent, advanced prostate cancer manifests with aggressive and often lethal variants, including neuroendocrine prostate cancer (NEPC). To identify drivers of aggressive prostate cancer, we…
View article: Elucidating Compound Mechanism of Action and Polypharmacology with a Large-scale Perturbational Profile Compendium
Elucidating Compound Mechanism of Action and Polypharmacology with a Large-scale Perturbational Profile Compendium Open
Drug Mechanism of Action (MoA) is generally represented as a small repertoire of tissue-independent, high-affinity binding targets. Yet, drug activity and polypharmacology are associated with a broad range of off-target and tissue-specific…
View article: PyVIPER: A fast and scalable Python package for rank-based enrichment analysis of single-cell RNASeq data
PyVIPER: A fast and scalable Python package for rank-based enrichment analysis of single-cell RNASeq data Open
Data Repository for VIPER analysis in Python. These data are used in Tutorials of the PyVIPER package. All files were generated by post-processing publicly available data from pancreatic ductal adenocarcinoma (PDAC) patients by Peng et al.…
View article: PyVIPER: A fast and scalable Python package for rank-based enrichment analysis of single-cell RNASeq data
PyVIPER: A fast and scalable Python package for rank-based enrichment analysis of single-cell RNASeq data Open
Data Repository for VIPER analysis in Python. These data are used in Tutorials of the PyVIPER package. All files were generated by post-processing publicly available data from pancreatic ductal adenocarcinoma (PDAC) patients by Peng et al.…
View article: Systematic, Protein Activity-based Characterization of Single Cell State
Systematic, Protein Activity-based Characterization of Single Cell State Open
While single-cell RNA sequencing provides a remarkable window on pathophysiologic tissue biology and heterogeneity, its high gene-dropout rate and low signal-to-noise ratio challenge quantitative analyses and mechanistic understanding. To …
View article: Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer
Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer Open
Despite extensive efforts, reproducible assessment of pancreatic ductal adenocarcinoma (PDA) heterogeneity and plasticity at the single cell level remains elusive. Systematic, network-based analysis of regulatory protein activity in single…
View article: E-028 Delayed cranial nerve palsy after transvenous embolization of indirect carotid cavernous fistulae
E-028 Delayed cranial nerve palsy after transvenous embolization of indirect carotid cavernous fistulae Open
Introduction Carotid cavernous fistulae (CCF) can present with diplopia secondary to cranial nerve palsy (CNP). Immediate development of post operative CNP has been described in the literature. This study discusses delayed presentation of …