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View article: The Role of Albuminuria in Diagnosing and Stratifying Kidney Disease in Heart Transplant Recipients: A KDIGO Criteria‐Based Analysis
The Role of Albuminuria in Diagnosing and Stratifying Kidney Disease in Heart Transplant Recipients: A KDIGO Criteria‐Based Analysis Open
Background Chronic kidney disease (CKD) is a common but poorly characterized complication in heart transplant (HT) recipients due to limited use of renal damage markers, such as albuminuria. Our aim is to determine CKD prevalence based on …
View article: #1750 Protein-bound uremic toxins removal with post-dilutional hemodiafiltration with high convective volume: a transversal study from hospital clinic Barcelona
#1750 Protein-bound uremic toxins removal with post-dilutional hemodiafiltration with high convective volume: a transversal study from hospital clinic Barcelona Open
Background and Aims Protein-bound uremic toxins (PBUTs) are low-molecular-weight uremic toxins which encompass different molecules, with indoxyl sulfate (IS) and p-cresyl sulfate (pCS) being two of the most toxic. Both are related to incre…
View article: Anemia and iron deficiency in post-kidney transplantation: an unsolved challenge
Anemia and iron deficiency in post-kidney transplantation: an unsolved challenge Open
Anemia and iron deficiency (ID) are common and significant complications in kidney transplant recipients (KTRs) that can affect their health-related quality of life (HRQoL) and outcomes. Current anemia guidelines equate the post-transplant…
View article: Systemic inflammation prevalence in patients with atherosclerotic cardiovascular disease and chronic kidney disease: a population-based study using a nationwide primary care database in Spain
Systemic inflammation prevalence in patients with atherosclerotic cardiovascular disease and chronic kidney disease: a population-based study using a nationwide primary care database in Spain Open
Introduction Systemic inflammation is recognised as a critical driver of atherosclerotic cardiovascular disease (ASCVD), especially in patients with comorbid chronic kidney disease (CKD). This study aims to assess the prevalence of systemi…
View article: Anemia Management in the Cardiorenal Patient: A Nephrological Perspective
Anemia Management in the Cardiorenal Patient: A Nephrological Perspective Open
Heart failure (HF) and chronic kidney disease (CKD) frequently coexist, sharing significant overlap in prevalence and pathophysiological mechanisms. This coexistence, termed cardiorenal syndrome (CRS), often leads to anemia, which exacerba…
View article: Gut Dysbiosis and Its Role in the Anemia of Chronic Kidney Disease
Gut Dysbiosis and Its Role in the Anemia of Chronic Kidney Disease Open
The gut dysbiosis present in chronic kidney disease (CKD) has been associated with anemia. Factors such as the accumulation of gut-derived uremic toxins, increased gut barrier permeability-induced inflammation, and a reduced intestinal pro…
View article: Using Chronic Kidney Disease as a Model Framework to Estimate Healthcare-Related Environmental Impact
Using Chronic Kidney Disease as a Model Framework to Estimate Healthcare-Related Environmental Impact Open
Full care pathways should be analysed alongside specific healthcare processes. Application of this framework enables quantification of the environmental benefits of preventative medicine and effective management of chronic diseases. For CK…
View article: Cardiovascular-kidney-metabolic syndrome definition and its role in the prevention, risk staging, and treatment. An opportunity for the Nephrology
Cardiovascular-kidney-metabolic syndrome definition and its role in the prevention, risk staging, and treatment. An opportunity for the Nephrology Open
The recent conceptualization of the cardiovascular-kidney-metabolic (CKM) syndrome by the American Heart Association (AHA) opens an opportunity for a multidisciplinary and lifelong approach in the risk stratification, early prevention, and…
View article: Systemic inflammation in patients with atherosclerotic cardiovascular and chronic kidney disease in Spain: a population-based study using electronic medical records from a primary care database
Systemic inflammation in patients with atherosclerotic cardiovascular and chronic kidney disease in Spain: a population-based study using electronic medical records from a primary care database Open
Background Systemic inflammation (SI) is recognized as a critical driver of atherosclerotic cardiovascular disease (ASCVD), and it is frequently observed in ASCVD patients with comorbid chronic kidney disease (CKD). Elevated C-reactive pro…
View article: Challenges in perioperative blood transfusions in kidney transplantation and the need for Patient Blood Management.
Challenges in perioperative blood transfusions in kidney transplantation and the need for Patient Blood Management. Open
In conclusion, PBM guidelines should be applied to patients on the KTx deceased donor waiting list and especially those scheduled to receive a transplant from a living donor. This could potentially increase the utilization efficiency of bl…
View article: #2617 Impact of CKD screening in high‑risk populations and guideline-directed therapy on RRT, CV events, and mortality in Europe: an IMPACT CKD analysis
#2617 Impact of CKD screening in high‑risk populations and guideline-directed therapy on RRT, CV events, and mortality in Europe: an IMPACT CKD analysis Open
Background and Aims Despite the rising and substantial burden of chronic kidney disease (CKD), there is a lack of recognition of CKD as a health priority in Europe. This contributes to underdiagnosis of CKD despite the potential for early …
View article: #2188 Challenges in lipid control in the advanced chronic kidney disease clinic: findings from a cross-sectional study
#2188 Challenges in lipid control in the advanced chronic kidney disease clinic: findings from a cross-sectional study Open
Background and Aims Chronic kidney disease (CKD) is associated with lipid metabolism disruptions and heightens cardiovascular (CV) risk. International guidelines categorize CKD patients into high CV risk (LDL target < 70 mg/dL and a red…
View article: Effect of Intravenous Ferric Carboxymaltose on Functional Capacity, Fatigue, and Quality of Life in Elderly Patients with Chronic Kidney Disease Not on Dialysis, Mild Anemia and Iron Deficiency. A Pilot Study
Effect of Intravenous Ferric Carboxymaltose on Functional Capacity, Fatigue, and Quality of Life in Elderly Patients with Chronic Kidney Disease Not on Dialysis, Mild Anemia and Iron Deficiency. A Pilot Study Open
Iron deficiency (ID) is highly prevalent in chronic kidney disease (CKD) and it’s associated with poorer quality of life (QoL) and functional capacity. Intravenous (IV) iron therapy is limited to CKD patients with ID and anemia to avoid/de…
View article: Effect of SGLT2 inhibitors on anemia and their possible clinical implications
Effect of SGLT2 inhibitors on anemia and their possible clinical implications Open
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have demonstrated cardiovascular and renal benefits in patients with type 2 diabetes mellitus, heart failure, or chronic kidney disease. Since the first studies with these drugs, an initia…
View article: Comparison of outcomes on hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) in anaemia associated with chronic kidney disease: network meta-analyses in dialysis and non-dialysis dependent populations
Comparison of outcomes on hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) in anaemia associated with chronic kidney disease: network meta-analyses in dialysis and non-dialysis dependent populations Open
Background Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are oral alternatives to current standard-of-care treatments for anaemia in chronic kidney disease (CKD). We conducted network meta-analyses to indirectly compare…
View article: The ERA Registry Annual Report 2021: a summary
The ERA Registry Annual Report 2021: a summary Open
Background The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper is a summary of the ERA Registry Annual Report 2021, including a compar…
View article: Matrix Gla protein polymorphism rs1800802 is associated with atheroma plaque progression and with cardiovascular events in a chronic kidney disease cohort
Matrix Gla protein polymorphism rs1800802 is associated with atheroma plaque progression and with cardiovascular events in a chronic kidney disease cohort Open
Background Chronic kidney disease (CKD) is associated with increased atherosclerotic burden and higher risk for cardiovascular events (CVE). Atherosclerosis has a significant genetic component and, in CKD, it is influenced by mineral metab…
View article: Gender-specific risk factors and outcomes of hyperkalemia in CKD patients: smoking as a driver of hyperkalemia in men
Gender-specific risk factors and outcomes of hyperkalemia in CKD patients: smoking as a driver of hyperkalemia in men Open
Background Hyperkalemia is common among patients with chronic kidney disease (CKD) but there is scarce information on differential risk factors and outcomes for men and women. For instance, smoking has been suggested to be a risk factor fo…
View article: Epidemiology and treatment of renal anaemia in Spain: RIKAS retrospective study
Epidemiology and treatment of renal anaemia in Spain: RIKAS retrospective study Open
The prevalence of anaemia and inflammation increased with the disease severity, being higher in D-CKD. Iron parameters in anaemic patients treated or not with ESA are insufficient according to the guidelines, so there is room for improveme…
View article: Glucagon-like peptide 1(GLP-1) receptor agonists in the management of the patient with type 2diabetes mellitus and chronic kidney disease: an approach for the nephrologist
Glucagon-like peptide 1(GLP-1) receptor agonists in the management of the patient with type 2diabetes mellitus and chronic kidney disease: an approach for the nephrologist Open
Diabetic kidney disease, a common complication in patients with type 2 diabetes mellitus, is associated with a markedly increased morbidity and mortality, especially of cardiovascular origin, and faster progression to end-stage renal disea…
View article: Opportunities to improve the management of anemia in peritoneal dialysis patients: lessons from a national study in routine clinical practice
Opportunities to improve the management of anemia in peritoneal dialysis patients: lessons from a national study in routine clinical practice Open
Background Current guidelines establish the same hemoglobin (Hb) and iron biomarkers targets for hemodialysis (HD) and peritoneal dialysis (PD) in patients receiving erythropoiesis-stimulating agents (ESAs) even though patients having PD a…
View article: #3704 EU REGION-SPECIFIC CARDIOVASCULAR EVENT DATA FOR DAPRODUSTAT IN ASCEND-D AND ASCEND-ND
#3704 EU REGION-SPECIFIC CARDIOVASCULAR EVENT DATA FOR DAPRODUSTAT IN ASCEND-D AND ASCEND-ND Open
Background and Aims Daprodustat (GSK1278863) is a hypoxia-inducible factor prolyl hydroxylase inhibitor under investigation for the treatment of anaemia of chronic kidney disease. Phase 3 studies in dialysis (ASCEND-D) and non-dialysis (AS…
View article: #5864 EFFECT OF IV FERRIC CARBOXYMALTOSE ON PHYSICAL PERFORMANCE AND QOL IN PATIENTS WITH CKD NOT ON DIALYSIS, MILD ANEMIA AND IRON DEFICIENCY
#5864 EFFECT OF IV FERRIC CARBOXYMALTOSE ON PHYSICAL PERFORMANCE AND QOL IN PATIENTS WITH CKD NOT ON DIALYSIS, MILD ANEMIA AND IRON DEFICIENCY Open
Background and Aims Iron deficiency (ID) in patients with chronic kidney disease (CKD) is highly prevalent and contributes to a poorer quality of life. According to current guidelines, treatment with intravenous (IV) iron is limited to CKD…