Alejandra Maria Villamil
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View article: Prognostic value of liver stiffness measurement vs. biochemical response in primary biliary cholangitis
Prognostic value of liver stiffness measurement vs. biochemical response in primary biliary cholangitis Open
Both liver stiffness measurement (LSM) and biochemical response have prognostic significance in patients with primary biliary cholangitis. However, the clinical relevance and how discordant biochemical and LSM changes should be best interp…
View article: EFFICACY AND SAFETY OF SELADELPAR IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS AND COMPENSATED CIRRHOSIS IN THE PHASE 3 PLACEBO-CONTROLLED RESPONSE TRIAL
EFFICACY AND SAFETY OF SELADELPAR IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS AND COMPENSATED CIRRHOSIS IN THE PHASE 3 PLACEBO-CONTROLLED RESPONSE TRIAL Open
Introduction and Objectives: In the Phase 3 RESPONSE trial (NCT04620733), seladelpar, a first-in-class delpar (selective peroxisome proliferator–activated receptor delta agonist), significantly improved biomarkers of cholestasis in patient…
View article: AUTOIMMUNE HEPATITIS IN LATIN AMERICA: INSIGHTS FROM THE ALLATIN COHORT
AUTOIMMUNE HEPATITIS IN LATIN AMERICA: INSIGHTS FROM THE ALLATIN COHORT Open
Introduction and Objectives: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease associated with significant morbidity. Non-white ethnicity has been described as an independent predictor of adverse outcomes. Previous studies…
View article: Acute Liver Injury with Autoimmune Features after Sars-Cov-2 Vaccine: Autoimmune Hepatitis Versus Drug-Induced Autoimmune-Like Hepatitis
Acute Liver Injury with Autoimmune Features after Sars-Cov-2 Vaccine: Autoimmune Hepatitis Versus Drug-Induced Autoimmune-Like Hepatitis Open
View article: OP-1 LONG-TERM EFFICACY AND SAFETY OF OPEN-LABEL SELADELPAR TREATMENT IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS: INTERIM 2-YEAR RESULTS FROM THE ASSURE STUDY
OP-1 LONG-TERM EFFICACY AND SAFETY OF OPEN-LABEL SELADELPAR TREATMENT IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS: INTERIM 2-YEAR RESULTS FROM THE ASSURE STUDY Open
Conflict of interest: Yes, Full disclosures sent separately. Introduction and Objectives: Seladelpar reduces biochemical markers of cholestasis and pruritus in patients with primary biliary cholangitis. ASSURE (NCT03301506) is an ongoing, …
View article: COBALT: A Confirmatory Trial of Obeticholic Acid in Primary Biliary Cholangitis With Placebo and External Controls
COBALT: A Confirmatory Trial of Obeticholic Acid in Primary Biliary Cholangitis With Placebo and External Controls Open
INTRODUCTION: Obeticholic acid (OCA) treatment for primary biliary cholangitis (PBC) was conditionally approved in the phase 3 POISE trial. The COBALT confirmatory trial assessed whether clinical outcomes in patients with PBC improve with …
View article: Dynamics of Liver Stiffness Measurement and Clinical Course of Primary Biliary Cholangitis
Dynamics of Liver Stiffness Measurement and Clinical Course of Primary Biliary Cholangitis Open
View article: Prognostic scores for ursodeoxycholic acid-treated patients predict graft loss and mortality in recurrent primary biliary cholangitis after liver transplantation
Prognostic scores for ursodeoxycholic acid-treated patients predict graft loss and mortality in recurrent primary biliary cholangitis after liver transplantation Open
View article: Prognostic role of magnetic resonance imaging of the abdomen with intravenous contrast and magnetic resonance cholangiopancreatography in primary sclerosing cholangitis
Prognostic role of magnetic resonance imaging of the abdomen with intravenous contrast and magnetic resonance cholangiopancreatography in primary sclerosing cholangitis Open
Objective: To evaluate the usefulness of Anali scores, determined by magnetic resonance imaging, for predicting the prognosis of primary sclerosing cholangitis (PSC) and to analyze interobserver variability, as well as to assess the impact…
View article: Altered liver function test after <scp>Covid</scp>‐19 vaccines: A retrospective control group study
Altered liver function test after <span>Covid</span>‐19 vaccines: A retrospective control group study Open
Background and Purpose Liver injury after Covid‐19 vaccine has been described, although the incidence was not well established. We aimed to compare cumulative incidence of new onset liver test alteration after Covid‐19 vaccination, and to …
View article: Adequate versus deep response to ursodeoxycholic acid in primary biliary cholangitis: To what extent and under what conditions is normal alkaline phosphatase level associated with complication-free survival gain?
Adequate versus deep response to ursodeoxycholic acid in primary biliary cholangitis: To what extent and under what conditions is normal alkaline phosphatase level associated with complication-free survival gain? Open
Background and Aims: Normal alkaline phosphatase (ALP) levels in ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC) are associated with better long-term outcome. However, second-line therapies are currently…
View article: Histological and serological features of acute liver injury after SARS-CoV-2 vaccination
Histological and serological features of acute liver injury after SARS-CoV-2 vaccination Open
Cases of liver injury after vaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) have been published. We investigated a large international cohort of individuals with acute hepatitis after SARS-CoV-2 vaccin…