Alejandro Barranco-Almohalla
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View article: Differential regulation of insulin signalling by monomeric and oligomeric amyloid beta-peptide
Differential regulation of insulin signalling by monomeric and oligomeric amyloid beta-peptide Open
Alzheimer’s disease and Type 2 diabetes are pathological processes associated to ageing. Moreover, there are evidences supporting a mechanistic link between Alzheimer’s disease and insulin resistance (one of the first hallmarks of Type 2 d…
View article: Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2<i>α</i>
Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2<i>α</i> Open
Alzheimer’s disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (A β ) aggregates generate free radicals. Moreover, the aggregation of A β is increased by oxidative stress, and the neurotoxicity induced by the oli…