Alejandro Chibly
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View article: Deficiency in POLE exonuclease causes synthetic lethality in highly aneuploid cancer cells
Deficiency in POLE exonuclease causes synthetic lethality in highly aneuploid cancer cells Open
Summary Aneuploidy is a hallmark of cancer and is associated with drug resistance and poor clinical outcomes across diverse cancer types. However, no therapies have been clinically established to target highly aneuploid tumors. By analyzin…
View article: Epiregulon: Inference of single-cell transcription factor activity to predict drug response and drivers of cell state
Epiregulon: Inference of single-cell transcription factor activity to predict drug response and drivers of cell state Open
Transcription factors (TFs) and transcriptional coregulators represent an emerging class of therapeutic targets in oncology. Gene regulatory networks (GRNs) can be used to evaluate pharmacological agents targeting these factors and to iden…
View article: Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells
Neurotrophin signaling is a central mechanism of salivary dysfunction after irradiation that disrupts myoepithelial cells Open
The mechanisms that prevent regeneration of irradiated (IR) salivary glands remain elusive. Bulk RNAseq of IR versus non-IR human salivary glands showed that neurotrophin signaling is highly disrupted post-radiation. Neurotrophin receptors…
View article: scRNAseq of healthy and irradiated mouse parotid glands highlights crosstalk between immune and secretory cells during chronic injury
scRNAseq of healthy and irradiated mouse parotid glands highlights crosstalk between immune and secretory cells during chronic injury Open
SUMMARY Translational frameworks to understand the chronic loss of salivary dysfunction that follows after clinical irradiation, and the development of regenerative therapies remain an unmet clinical need. Understanding the transcriptional…
View article: Salivary gland function, development, and regeneration
Salivary gland function, development, and regeneration Open
Salivary glands produce and secrete saliva, which is essential for maintaining oral health and overall health. Understanding both the unique structure and physiological function of salivary glands, as well as how they are affected by disea…
View article: PG control_IR integrated seurat object
PG control_IR integrated seurat object Open
integrated Seurat v3 object with control and irradiated PG data
View article: Generation of a Single-Cell RNAseq Atlas of Murine Salivary Gland Development
Generation of a Single-Cell RNAseq Atlas of Murine Salivary Gland Development Open
Understanding the dynamic transcriptional landscape throughout organ development will provide a template for regenerative therapies. Here, we generated a single-cell RNA sequencing atlas of murine submandibular glands identifying transcrip…
View article: Postnatal SMG Integrated.rds
Postnatal SMG Integrated.rds Open
Redy-to-use Seurat objects associated with GSE150327 dataset (Salivary gland scRNAseq)The analysis code is available as supplementary material in the manuscript and in github repository: https://github.com/chiblyaa/Salivary-Gland-Developme…
View article: Embryonic SMG Integrated.rds
Embryonic SMG Integrated.rds Open
Redy-to-use Seurat objects associated with GSE150327 dataset (Salivary gland scRNAseq) The analysis code is available as supplementary material in the manuscript and in github repository: https://github.com/chiblyaa/Salivary-Gland-Developm…
View article: Postnatal SMG Integrated.rds
Postnatal SMG Integrated.rds Open
Redy-to-use Seurat objects associated with GSE150327 dataset (Salivary gland scRNAseq)The analysis code is available as supplementary material in the manuscript and in github repository: https://github.com/chiblyaa/Salivary-Gland-Developme…
View article: Embryonic SMG Integrated.rds
Embryonic SMG Integrated.rds Open
Redy-to-use Seurat objects associated with GSE150327 dataset (Salivary gland scRNAseq) published in manuscript ISCIENCE-D-20-01304The analysis code is available as supplementary material in the manuscript and in github repository: https://…
View article: Insulin-Like Growth Factor-1–Mediated DNA Repair in Irradiated Salivary Glands Is Sirtuin-1 Dependent
Insulin-Like Growth Factor-1–Mediated DNA Repair in Irradiated Salivary Glands Is Sirtuin-1 Dependent Open
Ionizing radiation is one of the most common cancer treatments; however, the treatment leads to a wide range of debilitating side effects. In patients with head and neck cancer (HNC), the surrounding normal salivary gland is extremely sens…