José A. Guevara-Patiño
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View article: Magnetoelectric Nanotherapy Achieves Complete Tumor Ablation and Prolonged Survival in Pancreatic Cancer Murine Models
Magnetoelectric Nanotherapy Achieves Complete Tumor Ablation and Prolonged Survival in Pancreatic Cancer Murine Models Open
Magnetoelectric nanoparticles (MENPs), when activated by a magnetic field, are shown to provide a minimally invasive, drug‐free, theranostic approach to pancreatic ductal adenocarcinoma (PDAC) treatment. The magnetoelectric effect allows i…
View article: NKG2D Signaling Certifies Effector CD8 T Cells for Anti-tumor Memory Formation 2320
NKG2D Signaling Certifies Effector CD8 T Cells for Anti-tumor Memory Formation 2320 Open
Description The development of long-term memory CD8 T cells from the initial effector pool is crucial for effective adaptive immunity. It is evolutionarily advantageous for the immune system to populate the memory compartment with CD8 T ce…
View article: Hypoxia-Induced Changes in Effector T Cells Are Linked to Poor Outcomes in Melanoma 2322
Hypoxia-Induced Changes in Effector T Cells Are Linked to Poor Outcomes in Melanoma 2322 Open
Description Our study highlights hypoxia’s impact on T cell localization and function in melanoma, emphasizing the importance of TME oxygenation in immunotherapy. Through mathematical modeling of melanoma tissue microarrays, we mapped CD4 …
View article: PV-10 Triggers Immunogenic Cell Death in Head and Neck Squamous Cell Carcinoma via Endoplasmic Reticulum Stress and Apoptosis
PV-10 Triggers Immunogenic Cell Death in Head and Neck Squamous Cell Carcinoma via Endoplasmic Reticulum Stress and Apoptosis Open
Primary risk factors of head and neck squamous cell carcinoma (HNSCC) include human papillomavirus infection and exposure to tobacco and excessive alcohol. Despite currently available treatments, patients with recurrent HNSCC still have po…
View article: Clinical significance of peripheral T-cell repertoire in head and neck squamous cell carcinoma treated with cetuximab and nivolumab
Clinical significance of peripheral T-cell repertoire in head and neck squamous cell carcinoma treated with cetuximab and nivolumab Open
Immunotherapy holds significant promise for treating head and neck squamous cell carcinoma (HNSCC), yet responses are limited to a subset of patients. This research investigates whether analyzing the peripheral T-cell receptor (TCR) repert…
View article: Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients
Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients Open
Background In the tumor microenvironment (TME), hypoxia stands as a significant factor that modulates immune responses, especially those driven by T cells. As T cell-based therapies often fail to work in solid tumors, this study aims to in…
View article: Nanoparticles use magnetoelectricity to target and eradicate cancer cells
Nanoparticles use magnetoelectricity to target and eradicate cancer cells Open
This study presents the first in vivo and in vitro evidence of an externally controlled, predictive, MRI-based nanotheranostic agent capable of cancer cell specific targeting and killing via irreversible electroporation (IRE) in solid tumo…
View article: Immune Assessment Today: Optimizing and Standardizing Efforts to Monitor Immune Responses in Cancer and Beyond
Immune Assessment Today: Optimizing and Standardizing Efforts to Monitor Immune Responses in Cancer and Beyond Open
As part of a symposium, current and former directors of Immune Monitoring cores and investigative oncologists presented insights into the past, present and future of immune assessment. Dr. Gnjatic presented a classification of immune monit…
View article: NKG2D receptor signaling shapes T cell thymic education
NKG2D receptor signaling shapes T cell thymic education Open
The role of natural killer group 2D (NKG2D) in peripheral T cells as a costimulatory receptor is well established. However, its contribution to T cell thymic education and functional imprint is unknown. Here, we report significant changes …
View article: Combination oncolytic virus, radiation therapy, and immune checkpoint inhibitor treatment in anti-PD-1-refractory cancer
Combination oncolytic virus, radiation therapy, and immune checkpoint inhibitor treatment in anti-PD-1-refractory cancer Open
Background Immunotherapies are becoming front-line treatments for many advanced cancers, and combinations of two or more therapies are beginning to be investigated. Based on their individual antitumor capabilities, we sought to determine w…
View article: Supplementary Table S1 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Supplementary Table S1 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Supplementary Table S1. TCGA Cohort
View article: Supplementary Table S5 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Supplementary Table S5 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Supplementary Table S5. Immune profile of the primary and recurrent tumors in Moffitt HNSCC cohort
View article: Supplementary Table S7 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Supplementary Table S7 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Supplementary Table S7. Core enriched genes in the TGF-β signaling
View article: Supplementary Figure S1 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Supplementary Figure S1 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
(A, B) Heatmap of molecular subgroups in two different HNSCC datasets (A) TCGA and (B) CPTAC. RNA expression data was z-normalized, each row represents a single gene in the hypoxia-immune signature gene list, each column represents a patie…
View article: Supplementary Table S2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Supplementary Table S2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Supplementary Table S2. CPTAC Cohort
View article: Supplementary Table S8 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Supplementary Table S8 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Supplementary Table S8. Hypoxia-Immune classification of Schmitz et al., window-of-opportunity trial (GSE109756)
View article: Supplementary Table S2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Supplementary Table S2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Supplementary Table S2. CPTAC Cohort
View article: Supplementary Figure S4 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Supplementary Figure S4 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
(A-C) Clinical Proteomic Tumor Analysis Consortium head and neck squamous cell carcinoma cohort. The gene expressions were compared for pathways enriched in: (A) Immune vs Hypoxia. Red: enriched in Immune, Blue: enriched in Hypoxia. (B) Im…
View article: FIGURE 5 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
FIGURE 5 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Cetuximab treatment benefits Hypoxia subgroup. A, Heatmap of gene expression data from pre- and post-cetuximab (CTX) treated patient samples. RNA expression data (GSE109756) was z-normalized, each row represents a single gene in the hypoxi…
View article: Supplementary Table S8 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Supplementary Table S8 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Supplementary Table S8. Hypoxia-Immune classification of Schmitz et al., window-of-opportunity trial (GSE109756)
View article: Supplementary Figure S6 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Supplementary Figure S6 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
TIMEx scores for the Immune gene signature among the 15 patients classified into the Hypoxia, Mixture and Immune subgroups.
View article: TABLE 2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
TABLE 2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Disease control given pembrolizumab or nivolumab monotherapy in Moffitt retrospective study cohort
View article: FIGURE 4 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
FIGURE 4 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Hypoxia subgroup has an enrichment of EGFR pathway. Pearson correlation coefficient for the TIMEx scores for the EGFR pathway and the Hypoxia gene signature among the TCGA (A), CPTAC (B), and Moffitt (C) HNSCC datasets. Expression distribu…
View article: FIGURE 2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
FIGURE 2 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Hypoxia subgroup has immunosuppressive TME. Boxplots showing cell counts distribution of different immune markers CAIX+ cells representing hypoxia marker (A), CD3+ T cells (B), CD8+ cytotoxic T cells (C), PCK+ tumor cells expressing PD-L1 …
View article: FIGURE 1 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
FIGURE 1 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Molecular classification and validation of hypoxia-immune signature in HNSCC. A, Heatmap of molecular subgroups in the Moffitt (n = 228) HNSCC cohort. RNA expression data were z-normalized, each row represents a single gene in the hypoxia-…
View article: Supplementary Table S1 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Supplementary Table S1 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Supplementary Table S1. TCGA Cohort
View article: FIGURE 4 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
FIGURE 4 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Hypoxia subgroup has an enrichment of EGFR pathway. Pearson correlation coefficient for the TIMEx scores for the EGFR pathway and the Hypoxia gene signature among the TCGA (A), CPTAC (B), and Moffitt (C) HNSCC datasets. Expression distribu…
View article: Supplementary Table S7 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Supplementary Table S7 from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma Open
Supplementary Table S7. Core enriched genes in the TGF-β signaling