Alejandro Mossi Albiach
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View article: WHOLE BRAIN SINGLE NUCLEUS TRANSCRIPTOMICS IN HUMAN: WHAT WE KNOW SO FAR
WHOLE BRAIN SINGLE NUCLEUS TRANSCRIPTOMICS IN HUMAN: WHAT WE KNOW SO FAR Open
Although single-cell RNA sequencing has revolutionized our understanding of the mammalian brain, the diversity of cell types that contribute to the human brain remains poorly understood. We therefore used high-throughput single-nucleus RNA…
View article: Futile wound healing drives mesenchymal-like cell phenotypes in human glioblastoma
Futile wound healing drives mesenchymal-like cell phenotypes in human glioblastoma Open
Glioblastoma is the deadliest brain cancer, characterized by large cellular diversity whose complexity and organizing principles are only starting to be uncovered. Both neurodevelopment-like and mesenchymal-like cell states have been descr…
View article: Transcriptomic diversity of cell types across the adult human brain
Transcriptomic diversity of cell types across the adult human brain Open
The human brain directs a wide range of complex behaviors ranging from fine motor skills to abstract intelligence and emotion. However, the diversity of cell types that support these skills has not been fully described. Here we used high-t…
View article: Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH
Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH Open
View article: Developmental landscape of human forebrain at a single-cell level identifies early waves of oligodendrogenesis
Developmental landscape of human forebrain at a single-cell level identifies early waves of oligodendrogenesis Open
Oligodendrogenesis in the human central nervous system has been observed mainly at the second trimester of gestation, a much later developmental stage compared to oligodendrogenesis in mice. Here, we characterize the transcriptomic neural …
View article: Scalable <i>in situ</i> single-cell profiling by electrophoretic capture of mRNA
Scalable <i>in situ</i> single-cell profiling by electrophoretic capture of mRNA Open
Methods to spatially profile the transcriptome are dominated by a trade-off between resolution and throughput. Here, we developed a method named EEL FISH that can rapidly process large tissue samples without compromising spatial resolution…
View article: EEL human visual cortex 445 genes RNA spatial data
EEL human visual cortex 445 genes RNA spatial data Open
Raw RNA locations of a visual cortex human brain section produced by EEL FISH for 445 genes. RNA files are in the .parquet format which can be opened with FISHscale (https://github.com/linnarsson-lab/FISHscale) or any oth…
View article: EEL human visual cortex 445 genes spatial RNA data
EEL human visual cortex 445 genes spatial RNA data Open
Raw RNA locations of a visual cortex human brain section produced by EEL FISH for 445 genes. RNA files are in the .parquet format which can be opened with FISHscale (https://github.com/linnarsson-lab/FISHscale) or any oth…
View article: EEL human visual cortex 445 genes RNA data
EEL human visual cortex 445 genes RNA data Open
Raw RNA locations of a visual cortex human brain section produced by EEL FISH for 445 genes. RNA files are in the .parquet format which can be opened with FISHscale (https://github.com/linnarsson-lab/FISHscale) or any oth…
View article: Molecular architecture of the developing mouse brain
Molecular architecture of the developing mouse brain Open