Alejandro Pironti
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View article: CRISPR-Cas–associated SCC <i>mec</i> Variants in Methicillin-resistant <i>Staphylococcus aureus</i> Evade Rapid Diagnostic Detection
CRISPR-Cas–associated SCC <i>mec</i> Variants in Methicillin-resistant <i>Staphylococcus aureus</i> Evade Rapid Diagnostic Detection Open
Rapid molecular assays guiding treatment of methicillin-resistant Staphylococcus aureus detect SCCmec (Xpert) or the SCCmec–orfX junction (BCID2). Sequence variation in this region can disrupt primer binding, yielding false-negative result…
View article: Establishing benchmarks for quantitative mapping of m <sup>6</sup> A by Nanopore Direct RNA Sequencing
Establishing benchmarks for quantitative mapping of m <sup>6</sup> A by Nanopore Direct RNA Sequencing Open
Nanopore direct RNA sequencing (DRS) coupled with Dorado modification-aware basecalling enables mapping of epitranscriptomic modifications including N 6 -methyladenosine (m 6 A) at the level of individual RNAs. However, a lack of systemati…
View article: <i>Staphylococcus aureus</i> LukMF′ targets neutrophils to promote skin and soft tissue infection
<i>Staphylococcus aureus</i> LukMF′ targets neutrophils to promote skin and soft tissue infection Open
Pathogens have evolved to be highly adapted to their natural host. Community-associated methicillin-resistant Staphylococcus aureus USA300, for instance, is a lineage responsible for the epidemic of skin and soft tissue infections (SSTIs) …
View article: Gastrointestinal colonization as a source of <i>Staphylococcus aureus</i> in atopic dermatitis
Gastrointestinal colonization as a source of <i>Staphylococcus aureus</i> in atopic dermatitis Open
Atopic dermatitis (AD) is a prevalent inflammatory skin disease with complex pathogenesis. Both skin and gut microbiota influence AD, with Staphylococcus aureus , in particular, exacerbating the disease. However, the relationship between S…
View article: Author response: Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent
Author response: Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent Open
View article: Author response: Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent
Author response: Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent Open
View article: Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent
Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent Open
Gastrointestinal (GI) colonization by methicillin-resistant Staphylococcus aureus (MRSA) is associated with a high risk of transmission and invasive disease in vulnerable populations. The immune and microbial factors that permit GI coloniz…
View article: Collagen binding adhesin restricts Staphylococcus aureus skin infection
Collagen binding adhesin restricts Staphylococcus aureus skin infection Open
Staphylococcus aureus causes approximately 80% of skin and soft tissue infections (SSTIs). Collagen is the most abundant human extracellular matrix protein with critical roles in wound healing, and S. aureus encodes a collagen binding adhe…
View article: Sex-dependent gastrointestinal colonization resistance to MRSA is microbiome and Th17 dependent
Sex-dependent gastrointestinal colonization resistance to MRSA is microbiome and Th17 dependent Open
Gastrointestinal (GI) colonization by methicillin-resistant Staphylococcus aureus (MRSA) is associated with a high risk of transmission and invasive disease in vulnerable populations. The immune and microbial factors that permit GI coloniz…
View article: Author response: Sex-dependent gastrointestinal colonization resistance to MRSA is microbiome and Th17 dependent
Author response: Sex-dependent gastrointestinal colonization resistance to MRSA is microbiome and Th17 dependent Open
View article: Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent
Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent Open
Gastrointestinal (GI) colonization by methicillin-resistant Staphylococcus aureus (MRSA) is associated with a high risk of transmission and invasive disease in vulnerable populations. The immune and microbial factors that permit GI coloniz…
View article: An integrated strain-level analytic pipeline utilizing longitudinal metagenomic data
An integrated strain-level analytic pipeline utilizing longitudinal metagenomic data Open
With the development of sequencing technology and analytic tools, studying within-species variations enhances the understanding of microbial biological processes. Nevertheless, most existing methods designed for strain-level analysis lack …
View article: Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent
Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent Open
Gastrointestinal (GI) colonization by methicillin-resistant Staphylococcus aureus (MRSA) is associated with a high risk of transmission and invasive disease in vulnerable populations. The immune and microbial factors that permit GI coloniz…
View article: Large-Scale S. aureus Screening with Molecular Epidemiology; the Role of MSSA and Community MRSA in Hospital Transmissions
Large-Scale S. aureus Screening with Molecular Epidemiology; the Role of MSSA and Community MRSA in Hospital Transmissions Open
Background: The frequency of Staphylococcus aureus transmission in hospitals is unknown: symptomatic infection may occur months after transmission and colonization, and infection prevention efforts rely on indirect measurements, rather tha…
View article: Microbiota and metabolic adaptation shape<i>Staphylococcus aureus</i>virulence and antimicrobial resistance during intestinal colonization
Microbiota and metabolic adaptation shape<i>Staphylococcus aureus</i>virulence and antimicrobial resistance during intestinal colonization Open
Depletion of microbiota increases susceptibility to gastrointestinal colonization and subsequent infection by opportunistic pathogens such as methicillin-resistant Staphylococcus aureus (MRSA). How the absence of gut microbiota impacts the…
View article: Author response: Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
Author response: Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open
View article: Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant<i>Staphylococcus aureus</i>
Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant<i>Staphylococcus aureus</i> Open
We recently described the evolution of a community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) USA300 variant responsible for an outbreak of skin and soft tissue infections. Acquisition of a mosaic version of the Φ11 pro…
View article: Identification of a proteolysis regulator for an essential enzyme in<i>Mycobacterium tuberculosis</i>
Identification of a proteolysis regulator for an essential enzyme in<i>Mycobacterium tuberculosis</i> Open
In Mycobacterium tuberculosis proteins that are post-translationally modified with Pup, a prokaryotic ubiquitin-like protein, can be degraded by proteasomes. While pupylation is reversible, mechanisms regulating substrate specificity have …
View article: Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open
The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…
View article: Author Response: Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
Author Response: Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open
The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…
View article: Reviewer #1 (Public Review): Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
Reviewer #1 (Public Review): Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open
The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…
View article: Author Response: Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
Author Response: Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open
The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…
View article: Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open
The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…
View article: Reviewer #2 (Public Review): Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
Reviewer #2 (Public Review): Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open
The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…
View article: <i>Staphylococcus aureus</i> senses human neutrophils via PerR to coordinate the expression of the toxin LukAB
<i>Staphylococcus aureus</i> senses human neutrophils via PerR to coordinate the expression of the toxin LukAB Open
Staphylococcus aureus is a gram-positive pathogen that poses a major health concern, in part due to its large array of virulence factors that allow infection and evasion of the immune system. One of these virulence factors is the bicompone…
View article: Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization
Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization Open
View article: Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open
The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…
View article: Aldehyde accumulation in <i>Mycobacterium tuberculosis</i> with defective proteasomal degradation results in copper sensitivity
Aldehyde accumulation in <i>Mycobacterium tuberculosis</i> with defective proteasomal degradation results in copper sensitivity Open
Mycobacterium tuberculosis is a major human pathogen and the causative agent of tuberculosis disease. M. tuberculosis is able to persist in the face of host-derived antimicrobial molecules nitric oxide (NO) and copper (Cu). However, M. tub…
View article: Quorum-sensing <i>agr</i> system of <i>Staphylococcus aureus</i> primes gene expression for protection from lethal oxidative stress
Quorum-sensing <i>agr</i> system of <i>Staphylococcus aureus</i> primes gene expression for protection from lethal oxidative stress Open
The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H 2 O 2 , a crucial host defense against S. aureus . We now report that…
View article: Aldehyde accumulation in<i>Mycobacterium tuberculosis</i>with defective proteasomal degradation results in copper sensitivity
Aldehyde accumulation in<i>Mycobacterium tuberculosis</i>with defective proteasomal degradation results in copper sensitivity Open
Mycobacterium tuberculosis is a major human pathogen and the causative agent of tuberculosis disease. M. tuberculosis is able to persist in the face of host-derived antimicrobial molecules nitric oxide and copper. However, M. tuberculosis …