Alejandro Ropolo
YOU?
Author Swipe
View article: VMP1 Constitutive Expression in Mice Dampens Pancreatic and Systemic Histopathological Damage in an Experimental Model of Severe Acute Pancreatitis
VMP1 Constitutive Expression in Mice Dampens Pancreatic and Systemic Histopathological Damage in an Experimental Model of Severe Acute Pancreatitis Open
Acute pancreatitis (AP) an inflammatory condition caused by the premature activation of pancreatic proteases, leads to organ damage, systemic inflammation, and multi-organ failure. Severe acute pancreatitis (SAP) has high morbidity and mor…
View article: Impact of Constitutive VMP1 Expression on Pancreatic and Systemic Histopathology in Severe Acute Pancreatitis
Impact of Constitutive VMP1 Expression on Pancreatic and Systemic Histopathology in Severe Acute Pancreatitis Open
Acute pancreatitis (AP) is a severe inflammatory condition caused by the premature acti-vation of pancreatic proteases, leading to organ damage, systemic inflammation, and multi-organ failure. Severe acute pancreatitis (SAP) has high morbi…
View article: Secretory Autophagy via VMP1-Containing Extracellular Vesicles in Pancreatic Stress Responses
Secretory Autophagy via VMP1-Containing Extracellular Vesicles in Pancreatic Stress Responses Open
Cellular stress activates mechanisms such as autophagy and vesicular trafficking to maintain homeostasis in pathological conditions like acute pancreatitis. Vacuole Membrane Protein 1 (VMP1), an autophagy-related protein implicated in panc…
View article: WCN24-2112 THE EFFECT OF AUTOPHAGY ON SENESCENCE DEVELOPMENT IN PROTOCOL BIOPSIES FROM KIDNEY TRANSPLANT PATIENTS
WCN24-2112 THE EFFECT OF AUTOPHAGY ON SENESCENCE DEVELOPMENT IN PROTOCOL BIOPSIES FROM KIDNEY TRANSPLANT PATIENTS Open
In kidney transplant, tissue expression of cyclin-dependent kinase inhibitors p16INK4a, a cellular senescence marker, is a strong predictor of poor allograft outcome. Autophagy is a tightly regulated cellular selfdegradation recycling proc…
View article: Ubiquitination Is a Novel Post-Translational Modification of VMP1 in Autophagy of Human Tumor Cells
Ubiquitination Is a Novel Post-Translational Modification of VMP1 in Autophagy of Human Tumor Cells Open
Autophagy is a tightly regulated catabolic process involved in the degradation and recycling of proteins and organelles. Ubiquitination plays an important role in the regulation of autophagy. Vacuole Membrane Protein 1 (VMP1) is an essenti…
View article: Ubiquitination is a novel post-translational modification of VMP1 in autophagy of human tumor cells
Ubiquitination is a novel post-translational modification of VMP1 in autophagy of human tumor cells Open
Autophagy is a tightly regulated catabolic process involved in the degradation and re-cycling of proteins and organelles. Ubiquitination plays an important role in the regulation of autophagy. Vacuole Membrane Protein 1 (VMP1) is an essent…
View article: Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis
Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis Open
Mitophagy and zymophagy are selective autophagy pathways early induced in acute pancreatitis that may explain the mild, auto limited, and more frequent clinical presentation of this disease. Adequate mitochondrial bioenergetics is necessar…
View article: A Novel E2F1-EP300-VMP1 Pathway Mediates Gemcitabine-Induced Autophagy in Pancreatic Cancer Cells Carrying Oncogenic KRAS
A Novel E2F1-EP300-VMP1 Pathway Mediates Gemcitabine-Induced Autophagy in Pancreatic Cancer Cells Carrying Oncogenic KRAS Open
Autophagy is an evolutionarily preserved degradation process of cytoplasmic cellular constituents, which participates in cell response to disease. We previously characterized VMP1 (Vacuole Membrane Protein 1) as an essential autophagy rela…
View article: HBV subgenotypes F1b and F4 replication induces an incomplete autophagic process in hepatocytes: Role of BCP and preCore mutations
HBV subgenotypes F1b and F4 replication induces an incomplete autophagic process in hepatocytes: Role of BCP and preCore mutations Open
Hepatitis B virus (HBV) genotypes and mutants have been associated with differences in clinical and virological characteristics. Autophagy is a cellular process that degrades long-lived proteins and damaged organelles. Viruses have evolved…
View article: VMP1-related autophagy induced by a fructose-rich diet in β-cells: its prevention by incretins
VMP1-related autophagy induced by a fructose-rich diet in β-cells: its prevention by incretins Open
The aim of the present study was to demonstrate the role of autophagy and incretins in the fructose-induced alteration of β-cell mass and function. Normal Wistar rats were fed (3 weeks) with a commercial diet without (C) or with 10% fructo…
View article: Autophagy in Cell Fate and Diseases
Autophagy in Cell Fate and Diseases Open
Autophagy pathway has been one of the hot topics during the last decade. From a general notion about its cellular role, autophagy becomes a more sophisticated phenomenon with significant implications in cellular homeostasis. Consequently, …