Alejandro Ruíz-Patiño
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View article: Molecular and clonal evolution of primary lesions vs. brain metastasis in EGFR-mutated NSCLC: a retrospective cohort study
Molecular and clonal evolution of primary lesions vs. brain metastasis in EGFR-mutated NSCLC: a retrospective cohort study Open
The molecular features of BM differ from those of the primary tumor. These results indicate that specific brain metastatic clones can also result in systemic progression.
View article: The concept, intention, and evaluation of the term treatment-refractory meningioma
The concept, intention, and evaluation of the term treatment-refractory meningioma Open
Background Treatment-refractory meningioma is a widely used term but lacks standardized criteria, impairing research comparability and treatment evaluation. The aim of this study was to assess the heterogeneity of patient populations label…
View article: Visceral crisis in a patient with non-small cell lung cancer and ROS1::SDC4 fusion: intrinsic resistance to entrectinib via L2026M mutation—a case report
Visceral crisis in a patient with non-small cell lung cancer and ROS1::SDC4 fusion: intrinsic resistance to entrectinib via L2026M mutation—a case report Open
The emergence of the L2026M mutation suggests a need for next-generation TKIs and combination strategies to overcome resistance. Future studies should explore novel inhibitors targeting ROS1 resistance pathways to improve outcomes in this …
View article: Germline Genetic Variants in Cancer Predisposition Genes in Patients From Latin America and the Caribbean
Germline Genetic Variants in Cancer Predisposition Genes in Patients From Latin America and the Caribbean Open
The importance of having region-specific data when planning health interventions has become evident in recent years. Nonetheless, several world regions, including Latin America and the Caribbean (LAC), still face significant challenges. Th…
View article: Somatic Landscape of Oncogenic Variants Across the Main Cancer Subtypes in Latin America: A Narrative Review
Somatic Landscape of Oncogenic Variants Across the Main Cancer Subtypes in Latin America: A Narrative Review Open
Variations in somatic genetic alterations can be observed across different cancer types and diverse populations. Understanding the frequency of oncogenic variants in specific populations helps elucidate carcinogenesis and risk factors, wit…
View article: Clinicogenomic and treatment outcomes in RET fusion-positive NSCLC: A multicenter study in Latin American Hispanic patients
Clinicogenomic and treatment outcomes in RET fusion-positive NSCLC: A multicenter study in Latin American Hispanic patients Open
This Latin American cohort of RET fusion-positive NSCLC patients exhibited consistent molecular features and treatment responses. Expanded access to RET-selective therapies is needed to optimize outcomes in this population.
View article: Molecular Tumor Board Improves Outcomes for Hispanic Patients With Advanced Solid Tumors
Molecular Tumor Board Improves Outcomes for Hispanic Patients With Advanced Solid Tumors Open
PURPOSE Multidisciplinary molecular tumor boards (MTBs) decode complex genomic data into clinical recommendations. Although MTBs are well-established in the oncology practice in developed countries, this strategy needs to be better explore…
View article: DICER1-associated central nervous system sarcoma: A comprehensive clinical and genomic characterization of case series of young adult patients
DICER1-associated central nervous system sarcoma: A comprehensive clinical and genomic characterization of case series of young adult patients Open
Background DICER1 alterations are associated with intracranial tumors in the pediatric population, including pineoblastoma, pituitary blastoma, and the recently described “primary DICER1-associated CNS sarcoma” (DCS). DCS is an extremely a…
View article: Application of Comprehensive Genomic Profiling-Based Next-Generation Sequencing Assay to Improve Cancer Care in a Developing Country
Application of Comprehensive Genomic Profiling-Based Next-Generation Sequencing Assay to Improve Cancer Care in a Developing Country Open
Purpose Identifying actionable oncogenic mutations have changed the therapeutic landscape in different types of tumors. This study investigated the utility of comprehensive genomic profiling (CGP), a hybrid capture-based next-generation se…
View article: Cost-utility analysis of genomic profiling in early breast cancer in Colombia
Cost-utility analysis of genomic profiling in early breast cancer in Colombia Open
Background: In Colombia, the best strategy to establish indication for adjuvant chemotherapy in early breast cancer (EBC) remains unknown. This study aimed to identify the cost-utility of Oncotype DX™ (ODX) or Mammaprint™ (MMP) tests to es…
View article: Integration of artificial intelligence and precision oncology in Latin America
Integration of artificial intelligence and precision oncology in Latin America Open
Next-generation medicine encompasses different concepts related to healthcare models and technological developments. In Latin America and the Caribbean, healthcare systems are quite different between countries, and cancer control is known …
View article: Durvalumab After Chemoradiation for Unresectable Stage III Non-Small Cell Lung Cancer: Inferior Outcomes and Lack of Health Equity in Hispanic Patients Treated With PACIFIC Protocol (LA1-CLICaP)
Durvalumab After Chemoradiation for Unresectable Stage III Non-Small Cell Lung Cancer: Inferior Outcomes and Lack of Health Equity in Hispanic Patients Treated With PACIFIC Protocol (LA1-CLICaP) Open
Objectives To compare the rate disparity between outcomes (overall survival (OS), progression-free survival (PFS), and safety) of concurrent chemoradiation (cCRT) followed by durvalumab in two patient cohorts with locally advanced (LA) sta…
View article: Human papillomavirus infection and lung adenocarcinoma: special benefit is observed in patients treated with immune checkpoint inhibitors
Human papillomavirus infection and lung adenocarcinoma: special benefit is observed in patients treated with immune checkpoint inhibitors Open
In patients with HPV+ lung adenocarcinoma, a significant benefit in overall response and survival outcomes is observed.
View article: STK11 and KEAP1 mutations in non-small cell lung cancer patients: Descriptive analysis and prognostic value among Hispanics (STRIKE registry-CLICaP)
STK11 and KEAP1 mutations in non-small cell lung cancer patients: Descriptive analysis and prognostic value among Hispanics (STRIKE registry-CLICaP) Open
This is the first large Hispanic cohort to study the impact of STK11 and KEAP1 mutations in NSCLC patient treated with ICI. Our data suggest that mutations in the above-mentioned genes are associated with PD-L1 expression levels and poor O…
View article: Bispecific Antibodies in Cancer Immunotherapy: A Novel Response to an Old Question
Bispecific Antibodies in Cancer Immunotherapy: A Novel Response to an Old Question Open
Immunotherapy has redefined the treatment of cancer patients and it is constantly generating new advances and approaches. Among the multiple options of immunotherapy, bispecific antibodies (bsAbs) represent a novel thoughtful approach. The…
View article: Case Report: Differential Genomics and Evolution of a Meningeal Melanoma Treated With Ipilimumab and Nivolumab
Case Report: Differential Genomics and Evolution of a Meningeal Melanoma Treated With Ipilimumab and Nivolumab Open
Primary melanocytic tumors of the CNS are extremely rare conditions, encompassing different disease processes including meningeal melanoma and meningeal melanocytosis. Its incidence range between 3-5%, with approximately 0.005 cases per 10…
View article: High Grade Meningiomas: Current Therapy Based on Tumor Biology
High Grade Meningiomas: Current Therapy Based on Tumor Biology Open
Atypical (WHO grade II) and malignant meningiomas (WHO Grade III) are a rare subset of primary intracranial tumors. Due to the high recurrence rate after surgical resection and radiotherapy, there has been a recent interest in exploring ot…
View article: KRAS and MET in non-small-cell lung cancer: two of the new kids on the ‘drivers’ block
KRAS and MET in non-small-cell lung cancer: two of the new kids on the ‘drivers’ block Open
Non-small-cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic management has advanced to identify various critical oncogenic mutations that promote lung cancer tumorigenesis. Subsequent studies have developed targeted ther…
View article: p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics
p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics Open
Widespread identification of KRAS exon 2 p.G12C mutations, especially in cases where NGS is not easily achieved is feasible at a population based level that can characterize regional and national patterns of mutation status. Furthermore, t…
View article: Efficacy of Osimertinib Plus Bevacizumab In Glioblastoma Patients With Simultaneous EGFR Amplification And EGFRvIII Mutation
Efficacy of Osimertinib Plus Bevacizumab In Glioblastoma Patients With Simultaneous EGFR Amplification And EGFRvIII Mutation Open
Background: Amplification of EGFR and its active mutant EGFRvIII are common in glioblastoma (GB). While EGFR and EGFRvIII play critical roles in pathogenesis, targeted therapy with EGFR-tyrosine kinase inhibitors (TKIs) or antibodies has s…
View article: Diagnosis and Management of Radiation Necrosis in Patients with Brain Metastases and Primary Tumors
Diagnosis and Management of Radiation Necrosis in Patients with Brain Metastases and Primary Tumors Open
The incidence of radiation necrosis has increased secondary to combined modality therapy for brain tumors and stereotactic radiosurgery. The pathology of progressive brain radiation necrosis (RN) primarily includes inflammation and angioge…
View article: Characteristics and outcomes of thymomas in <scp>L</scp>atin <scp>A</scp>merica: Results from over <scp>10</scp> years of experience (<scp>CLICaP‐LATimus</scp>)
Characteristics and outcomes of thymomas in <span>L</span>atin <span>A</span>merica: Results from over <span>10</span> years of experience (<span>CLICaP‐LATimus</span>) Open
Background Thymomas are a group of rare neoplasms of the anterior mediastinum. The objective of this study was to describe the demographics, clinical characteristics and treatment approaches in Latin America. Methods This was a retrospecti…