Alejandro Sosnik
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View article: Combined Effect of Size and Charge on the Interaction of Nanoparticles with Mucus-Mimicking Mucin Hydrogels
Combined Effect of Size and Charge on the Interaction of Nanoparticles with Mucus-Mimicking Mucin Hydrogels Open
Background/Objectives: Understanding the interactions between nanoparticles and mucosal tissues is crucial for the development of advanced drug delivery systems, as the diffusion behavior of nanoparticles through mucus is strongly influenc…
View article: Combined Effect of Size and Charge on the Interaction of Na-noparticles with Mucus-Mimicking Mucin Hydrogels
Combined Effect of Size and Charge on the Interaction of Na-noparticles with Mucus-Mimicking Mucin Hydrogels Open
Background/Objectives: Understanding the interactions between nanoparticles and mucosal tissues is crucial for the development of advanced drug delivery systems, as the diffusion behavior of nanoparticles through mucus is strongly influenc…
View article: Self‐Crosslinkable Bacterial Cellulose/Chitosan/Pectin Injectable Hydrogels: Design, Characterization and Preliminary Biological Performance
Self‐Crosslinkable Bacterial Cellulose/Chitosan/Pectin Injectable Hydrogels: Design, Characterization and Preliminary Biological Performance Open
In this study, multifunctional polysaccharide‐based injectable hydrogels were developed using chitosan (CS) and dialdehyde bacterial cellulose (D‐BC), interpenetrated with pectin (PT). The hydrogels exhibited rapid gelation, good water ret…
View article: Controlled Synthesis of Bimetallic Gold‐Silver Nanostars: Atomic Insights and Predictive Formation Model
Controlled Synthesis of Bimetallic Gold‐Silver Nanostars: Atomic Insights and Predictive Formation Model Open
The nucleation and growth of bimetallic gold‐silver nanostars (GNSs) are investigated to elucidate their atomic‐scale formation mechanism. Motivated by the increasing demand for nanomaterials with enhanced optical and catalytic properties,…
View article: Polymer-based nanocarriers to transport therapeutic biomacromolecules across the blood-brain barrier
Polymer-based nanocarriers to transport therapeutic biomacromolecules across the blood-brain barrier Open
Therapeutic biomacromolecules such as genetic material, antibodies, growth factors and enzymes represent a novel therapeutic alternative for neurological diseases and disorders. In comparison to traditional therapeutics, which are mainly b…
View article: Hybrid Amorphous Titanium Dioxide/Amphiphilic Graft Copolymer Nano-Sonosensitizers
Hybrid Amorphous Titanium Dioxide/Amphiphilic Graft Copolymer Nano-Sonosensitizers Open
Sonodynamic therapy (SDT) is an innovative anticancer strategy that combines a sonosensitizer with low-intensity ultrasound (US) to selectively kill cancer cells. Sonosensitizers can be classified into organic small-molecules, and inorgani…
View article: Functionalisation of chitosan with methacryloyl and crotonoyl groups as a strategy to enhance its mucoadhesive properties
Functionalisation of chitosan with methacryloyl and crotonoyl groups as a strategy to enhance its mucoadhesive properties Open
Mucoadhesive polymers are crucial for prolonging drug retention on mucosal surfaces. This study focuses on synthesising and characterising novel derivatives by reacting chitosan with crotonic and methacrylic anhydrides. The structure of th…
View article: Mucus‐Mimicking Mucin‐Based Hydrogels by Tandem Chemical and Physical Crosslinking
Mucus‐Mimicking Mucin‐Based Hydrogels by Tandem Chemical and Physical Crosslinking Open
Mucosal tissues represent a major interface between the body and the external environment and are covered by a highly hydrated mucins gel called mucus. Mucus lubricates, protects and modulates the moisture levels of the tissue and is capit…
View article: Solid-State Dewetting of Thin Au Films for Surface Functionalization of Biomedical Implants
Solid-State Dewetting of Thin Au Films for Surface Functionalization of Biomedical Implants Open
Biomaterial-centered infections of orthopedic implants remain a significant burden in the healthcare system due to sedentary lifestyles and an aging population. One approach to combat infections and improve implant osteointegration is func…
View article: Microfluidics for brain endothelial cell-astrocyte interactions
Microfluidics for brain endothelial cell-astrocyte interactions Open
With the approval of the Food and Drug (FDA) Modernization Act 2.0, the pharmaceutical industry is poised to expand its research components with a plethora of alternative models, including organ-on-microfluidic chips in pharma and biotechn…
View article: Glucosylated Hybrid TiO<sub>2</sub>/Polymer Nanomaterials for Actively Targeted Sonodynamic Therapy of Cancer
Glucosylated Hybrid TiO<sub>2</sub>/Polymer Nanomaterials for Actively Targeted Sonodynamic Therapy of Cancer Open
Sonodynamic therapy (SDT) is an anti‐cancer therapeutic strategy based on the generation of reactive oxygen species (ROS) upon local ultrasound (US) irradiation of sono‐responsive molecules or nanomaterials that accumulate in the tumor. In…
View article: Microfluidics for Brain Endothelial-Astrocytic Interactions
Microfluidics for Brain Endothelial-Astrocytic Interactions Open
With the approval of the FDA Modernization Act 2.0, the pharmaceutical industry is poised to expand its research components with a plethora of alternative models, including organ-on-microfluidic chips in pharma and biotechnology, resulting…
View article: Poly(ethylene glycol)-b-poly(epsilon-caprolactone) nanoparticles as a platform for the improved oral delivery of cannabidiol
Poly(ethylene glycol)-b-poly(epsilon-caprolactone) nanoparticles as a platform for the improved oral delivery of cannabidiol Open
Cannabidiol (CBD), a non-psychoactive constituent of Cannabis , has proven neuroprotective, anti-inflammatory and antioxidant properties though his therapeutic use, especially by the oral route, is still challenged by the poor aqueous solu…
View article: Drug-eluting biodegradable metals and metal-ceramic composites: High strength and delayed drug release
Drug-eluting biodegradable metals and metal-ceramic composites: High strength and delayed drug release Open
Biodegradable metals emerged as promising temporary bone implants. The integration of additional features such as local drug delivery (LDD) can also support their osteointegration, promote bone regeneration, and prevent biomaterial-centere…
View article: An experimental and theoretical approach to understand the interaction between particles and mucosal tissues
An experimental and theoretical approach to understand the interaction between particles and mucosal tissues Open
Nanonization of poorly water-soluble drugs has shown great potential in improving their oral bioavailability by enhancing the dissolution rate and saturation solubility. Moreover, due to particle size reduction and larger surface area, the…
View article: Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders
Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders Open
Neurodegenerative diseases are progressive conditions that affect the neurons of the central nervous system (CNS) and result in their damage and death. Neurodevelopmental disorders include intellectual disability, autism spectrum disorder,…