Alekhya Mandali
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View article: Beyond the surface: a review of transcranial temporal interference stimulation for deep brain modulation
Beyond the surface: a review of transcranial temporal interference stimulation for deep brain modulation Open
Temporal Interference (TI) stimulation has emerged as a novel, non-invasive technique for selectively modulating deep brain regions while minimizing stimulation of superficial cortical layers, addressing key limitations of traditional tran…
View article: Tuning the brakes – Modulatory role of transcranial random noise stimulation on inhibition
Tuning the brakes – Modulatory role of transcranial random noise stimulation on inhibition Open
Cognitive control is an executive function that governs our ability to learn, modify and update actions flexibly [[1]Braver T.S. The variable nature of cognitive control: a dual mechanisms framework.Trends Cognit Sci. 2012; 16: 106-113Abst…
View article: Tuning the brakes – Modulatory role of transcranial random noise stimulation on inhibition
Tuning the brakes – Modulatory role of transcranial random noise stimulation on inhibition Open
Background Everyday decision-making requires the ability to flexibly modify and sometimes terminate our actions, such as avoiding a tempting slice of cake to hitting the brakes in an emergency. Neural oscillations, such as beta-band rhythm…
View article: Cortical paired associative stimulation shows impaired plasticity of inhibition networks as a function of chronic alcohol use
Cortical paired associative stimulation shows impaired plasticity of inhibition networks as a function of chronic alcohol use Open
Background Response inhibition − or the ability to withhold a suboptimal response − relies on the efficacy of fronto-striatal networks, and is impaired in neuropsychiatric disorders including addiction. Cortical paired associative stimulat…
View article: Power signatures of habenular neuronal signals in patients with bipolar or unipolar depressive disorders correlate with their disease severity
Power signatures of habenular neuronal signals in patients with bipolar or unipolar depressive disorders correlate with their disease severity Open
The habenula is an epithalamic structure implicated in negative reward mechanisms and plays a downstream modulatory role in regulation of dopaminergic and serotonergic functions. Human and animal studies show its hyperactivity in depressio…
View article: Compulsiveness Drives Evidence Accumulation During Ambiguity
Compulsiveness Drives Evidence Accumulation During Ambiguity Open
Doubt can modulate our decision-making process. Although conceptually different, conflict (choice similarity: difficult or easy) and uncertainty (individual reward-likelihoods: uncertain or certain) are commonly related and often conflated…
View article: 16 Effect of methylphenidate on risk preference in attention deficit hyperactivity disorder
16 Effect of methylphenidate on risk preference in attention deficit hyperactivity disorder Open
Introduction Methylphenidate (MPH) is one of most commonly prescribed drug to patients with Attention Deficit Hyperactivity Disorder (ADHD). While MPH has been known to improve executive functions, its effect on impulsivity, one of the car…
View article: 43 Effect of dopaminergic medication on risk preference in parkinson’s disease
43 Effect of dopaminergic medication on risk preference in parkinson’s disease Open
Introduction Dopaminergic medication being the standard therapeutic treatment improves motor symptoms in Parkinson's disease (PD) but also implicated in the occurrence of impulse control disorders. Data driven computational models such as …
View article: A Computational Model of Loss of Dopaminergic Cells in Parkinson's Disease Due to Glutamate-Induced Excitotoxicity
A Computational Model of Loss of Dopaminergic Cells in Parkinson's Disease Due to Glutamate-Induced Excitotoxicity Open
Parkinson's disease (PD) is a neurodegenerative disease associated with progressive and inexorable loss of dopaminergic cells in Substantia Nigra pars compacta (SNc). Although many mechanisms have been suggested, a decisive root cause of t…
View article: The ease and sureness of a decision: evidence accumulation of conflict and uncertainty
The ease and sureness of a decision: evidence accumulation of conflict and uncertainty Open
The likelihood of an outcome (uncertainty or sureness) and the similarity between choices (conflict or ease of a decision) are often critical to decision-making. We often ask ourselves: how likely are we to win or lose? And how different i…
View article: A computational model of loss of dopaminergic cells in Parkinson’s disease due to glutamate-induced excitotoxicity
A computational model of loss of dopaminergic cells in Parkinson’s disease due to glutamate-induced excitotoxicity Open
Parkinson’s disease (PD) is a neurodegenerative disease associated with progressive and inexorable loss of dopaminergic cells in Substantia Nigra pars compacta (SNc). A full understanding of the underlying pathogenesis of this cell loss is…
View article: Electrode Position and Current Amplitude Modulate Impulsivity after Subthalamic Stimulation in Parkinsons Disease—A Computational Study
Electrode Position and Current Amplitude Modulate Impulsivity after Subthalamic Stimulation in Parkinsons Disease—A Computational Study Open
Background: Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) is highly effective in alleviating motor symptoms of Parkinson's disease (PD) which are not optimally controlled by dopamine replacement therapy. Clinical studies and reports…
View article: Probing the Role of Medication, DBS Electrode Position, and Antidromic Activation on Impulsivity Using a Computational Model of Basal Ganglia
Probing the Role of Medication, DBS Electrode Position, and Antidromic Activation on Impulsivity Using a Computational Model of Basal Ganglia Open
Everyday, we encounter situations where available choices are nearly equally rewarding (high conflict) calling for some tough decision making. Experimental recordings showed that the activity of Sub Thalamic Nucleus (STN) increases during …
View article: A spiking network model of basal ganglia to study the effect of dopamine medication and STN-DBS during probabilistic learning task
A spiking network model of basal ganglia to study the effect of dopamine medication and STN-DBS during probabilistic learning task Open
The effect of dopamine medication (L
View article: A spiking Basal Ganglia model of synchrony, exploration and decision making
A spiking Basal Ganglia model of synchrony, exploration and decision making Open
To make an optimal decision we need to weigh all the available options, compare them with the current goal, and choose the most rewarding one. Depending on the situation an optimal decision could be to either "explore" or "exploit" or "not…