Aleksandra Borek
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View article: What Are the Important Health and Well‐Being Outcome Dimensions for Parent Carers of Disabled Children? A Qualitative Study
What Are the Important Health and Well‐Being Outcome Dimensions for Parent Carers of Disabled Children? A Qualitative Study Open
Background Patient‐reported outcome measures (PROMs) are used to evaluate the effectiveness of interventions, particularly for subjective health states such as well‐being. A parent carer is an adult primary caregiver for a child with a dis…
View article: Adapting a Participatory Group Programme for Caregivers of Children with Complex Neurodisability from Low-, Middle-Income Countries to a High-Income Setting: Moving from “Baby Ubuntu” to “Encompass”
Adapting a Participatory Group Programme for Caregivers of Children with Complex Neurodisability from Low-, Middle-Income Countries to a High-Income Setting: Moving from “Baby Ubuntu” to “Encompass” Open
The “Baby Ubuntu” programme is a well-established, low-cost, community-based intervention to support caregivers of children with complex neurodisability, like cerebral palsy, in low- and middle-income country (LMIC) contexts. This process-…
View article: Improving the health and wellbeing of parent carers of disabled children: systematic and iterative development and evaluation of a peer-led group-based programme
Improving the health and wellbeing of parent carers of disabled children: systematic and iterative development and evaluation of a peer-led group-based programme Open
View article: The role of community pharmacists with Syrian migration background in addressing healthcare needs of migrant population in Germany: a qualitative study
The role of community pharmacists with Syrian migration background in addressing healthcare needs of migrant population in Germany: a qualitative study Open
This study explored the role of migrant pharmacists, particularly those from Syria, in addressing the healthcare needs of migrants in Germany. Their ability to communicate in both Arabic and German and to understand cultural nuances is a k…
View article: Retrograde autobiographical amnesia following electroconvulsive therapy in patients treated for depression - a mixed-methods systematic review with meta-analysis and thematic meta-synthesis
Retrograde autobiographical amnesia following electroconvulsive therapy in patients treated for depression - a mixed-methods systematic review with meta-analysis and thematic meta-synthesis Open
Introduction Electroconvulsive therapy (ECT) is a treatment received by approximately 1.4 million people worldwide annually, depressive disorder being the most prevalent indication. Retrograde autobiographical amnesia (RAA) refers to diffi…
View article: The sepsis journey and where digital alerts can help: a qualitative, interview study with survivors and family members in England
The sepsis journey and where digital alerts can help: a qualitative, interview study with survivors and family members in England Open
Introduction The fight against sepsis is an ongoing healthcare challenge, where digital tools are increasingly used with some promising results. The experience of survivors and their family members can help optimize digital alerts for seps…
View article: Acceptability of self-sampling and self-testing for infections: a rapid systematic review on public users’ views
Acceptability of self-sampling and self-testing for infections: a rapid systematic review on public users’ views Open
View article: Ensuring equitable access, engagement and ability of socially and ethnically diverse participants to benefit from health promotion programmes: a qualitative study with parent carers of disabled children
Ensuring equitable access, engagement and ability of socially and ethnically diverse participants to benefit from health promotion programmes: a qualitative study with parent carers of disabled children Open
Background Equity is fundamental to health promotion programmes. However, unintentional or unseen barriers may exist for some underserved groups. We aimed to identify how to ensure equitable access and engagement for diverse parent carers …
View article: Developing a data-enabled nudge intervention for childhood antibiotics in primary care: a qualitative study
Developing a data-enabled nudge intervention for childhood antibiotics in primary care: a qualitative study Open
Background Preschool children (aged ≤5 years) have the highest antibiotic prescribing rate in general practice, mostly for self-limiting acute respiratory tract infections (RTIs). Research from >250 000 UK children suggests that a child’s …
View article: Stop antibiotics when you feel better? Opportunities, challenges and research directions
Stop antibiotics when you feel better? Opportunities, challenges and research directions Open
Shortening standard antibiotic courses and stopping antibiotics when patients feel better are two ways to reduce exposure to antibiotics in the community, and decrease the risks of antimicrobial resistance and antibiotic side effects. Whil…
View article: Views and Uses of Sepsis Digital Alerts in National Health Service Trusts in England: Qualitative Study With Health Care Professionals
Views and Uses of Sepsis Digital Alerts in National Health Service Trusts in England: Qualitative Study With Health Care Professionals Open
Background Sepsis is a common cause of serious illness and death. Sepsis management remains challenging and suboptimal. To support rapid sepsis diagnosis and treatment, screening tools have been embedded into hospital digital systems to ap…
View article: What aspects of health and wellbeing are most important to parent carers of children with disabilities?
What aspects of health and wellbeing are most important to parent carers of children with disabilities? Open
Introduction Parent carers of children with special educational needs or disabilities are at risk of poorer health and wellbeing outcomes because of the distinct and challenging circumstances they face. Evaluations of interventions promoti…
View article: Referee report. For: Behaviour change interventions addressing antibiotic treatment seeking behaviour for respiratory tract infections in primary care settings: A scoping review protocol [version 1; peer review: 1 approved with reservations, 1 not approved]
Referee report. For: Behaviour change interventions addressing antibiotic treatment seeking behaviour for respiratory tract infections in primary care settings: A scoping review protocol [version 1; peer review: 1 approved with reservations, 1 not approved] Open
View article: How, why and when are delayed (back-up) antibiotic prescriptions used in primary care? A realist review integrating concepts of uncertainty in healthcare
How, why and when are delayed (back-up) antibiotic prescriptions used in primary care? A realist review integrating concepts of uncertainty in healthcare Open
Background Antimicrobial resistance is a global patient safety priority and inappropriate antimicrobial use is a key contributing factor. Trials have shown that delayed (back-up) antibiotic prescriptions (DP) are an effective and safe stra…
View article: Impact of the COVID-19 pandemic on antimicrobial stewardship support for general practices in England: a qualitative interview study
Impact of the COVID-19 pandemic on antimicrobial stewardship support for general practices in England: a qualitative interview study Open
Background In England, clinical commissioning group (CCG; now replaced by Integrated Care Systems [ICSs]) and primary care network (PCN) professionals support primary care prescribers to optimise antimicrobial stewardship (AMS). Aim To exp…
View article: Data from High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer
Data from High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer Open
Targeted delivery of anticancer drugs using antibodies specific for tumor-associated antigens represents one of the most important approaches in current immuno-oncology research. Fibroblast growth factor receptor 1 (FGFR1) has been demonst…
View article: Supplementary Data from High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer
Supplementary Data from High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer Open
Supplementary Materials and Methods - Description of affinity maturation procedure used in the study and of the preparation of scFvD2 diabody and scFvD2-Fc; Supplementary Figure S1 - Reactivity of scFv clones against Fc fragment; Supplemen…
View article: Supplementary Data from High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer
Supplementary Data from High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer Open
Supplementary Materials and Methods - Description of affinity maturation procedure used in the study and of the preparation of scFvD2 diabody and scFvD2-Fc; Supplementary Figure S1 - Reactivity of scFv clones against Fc fragment; Supplemen…
View article: Re-examining advice to complete antibiotic courses: a qualitative study with clinicians and patients
Re-examining advice to complete antibiotic courses: a qualitative study with clinicians and patients Open
Background Antibiotic treatment duration may be longer than sometimes needed. Stopping antibiotics early, rather than completing pre-set antibiotic courses, may help reduce unnecessary exposure to antibiotics and antimicrobial resistance (…
View article: Implementing antibiotic stewardship in high-prescribing English general practices: a mixed-methods study
Implementing antibiotic stewardship in high-prescribing English general practices: a mixed-methods study Open
Background Trials have identified antimicrobial stewardship (AMS) strategies that effectively reduce antibiotic use in primary care. However, many are not commonly used in England. The authors co-developed an implementation intervention to…
View article: Conducting rapid qualitative interview research during the COVID-19 pandemic—Reflections on methodological choices
Conducting rapid qualitative interview research during the COVID-19 pandemic—Reflections on methodological choices Open
As the COVID-19 pandemic has shown, setting up studies in time to gather relevant, real-world data enables researchers to capture current views and experiences, focus on practicalities on the ground, and deliver actionable results. Deliver…
View article: O01 Nuances of implementing antibiotic stewardship in high-prescribing English general practices: an implementation study
O01 Nuances of implementing antibiotic stewardship in high-prescribing English general practices: an implementation study Open
Background Trials have identified several antimicrobial stewardship (AMS) strategies that effectively reduce antibiotic use in primary care. However, many are not commonly used in England and evidence is lacking around how to support high-…
View article: Experiences and concerns of health workers throughout the first year of the COVID-19 pandemic in the UK: A longitudinal qualitative interview study
Experiences and concerns of health workers throughout the first year of the COVID-19 pandemic in the UK: A longitudinal qualitative interview study Open
Objective To identify the experiences and concerns of health workers (HWs), and how they changed, throughout the first year of the COVID-19 pandemic in the UK. Methods Longitudinal, qualitative study with HWs involved in patient management…
View article: Play‐based groups for children with cerebral palsy and their parents: A qualitative interview study about the impact on mothers' well‐being
Play‐based groups for children with cerebral palsy and their parents: A qualitative interview study about the impact on mothers' well‐being Open
Background Cerebral palsy (CP) is the most common childhood physical disability in developed countries. Parents of children with CP experience difficulties that can result in reduced well‐being. Health professionals supporting children wit…
View article: Impact of the COVID-19 pandemic on community antibiotic prescribing and stewardship: a qualitative interview study with general practitioners in England
Impact of the COVID-19 pandemic on community antibiotic prescribing and stewardship: a qualitative interview study with general practitioners in England Open
The COVID-19 pandemic has had a profound impact on the delivery of primary care services. We aimed to identify general practitioners’ (GPs’) perceptions and experiences of how the COVID-19 pandemic influenced antibiotic prescribing and ant…
View article: Value, challenges and practical considerations when designing, conducting and analysing a longitudinal qualitative study in family medicine
Value, challenges and practical considerations when designing, conducting and analysing a longitudinal qualitative study in family medicine Open
Qualitative longitudinal design has a long tradition in a variety of social science disciplines and is increasingly used in applied healthcare research, including family medicine. While there are many definitions of longitudinal qualitativ…
View article: 1 Exploring the implementation of interventions to reduce antibiotic use (ENACT study)
1 Exploring the implementation of interventions to reduce antibiotic use (ENACT study) Open
While a number of interventions to optimise antibiotic prescribing in primary care exist, it remains unclear which influences on prescribing behaviour they target, how well, and how these interventions could be improved to further optimise…
View article: Gender in the consolidated criteria for reporting qualitative research (COREQ) checklist
Gender in the consolidated criteria for reporting qualitative research (COREQ) checklist Open
View article: Perspectives on COVID-19 testing policies and practices: a qualitative study with scientific advisors and NHS health care workers in England
Perspectives on COVID-19 testing policies and practices: a qualitative study with scientific advisors and NHS health care workers in England Open
Background As COVID-19 death rates have risen and health-care systems have experienced increased demand, national testing strategies have come under scrutiny. Utilising qualitative interview data from a larger COVID-19 study, this paper pr…
View article: Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE): protocol for a randomised, controlled, open-label, adaptive platform, trial of community treatment of COVID-19 syndromic illness in people at higher risk
Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE): protocol for a randomised, controlled, open-label, adaptive platform, trial of community treatment of COVID-19 syndromic illness in people at higher risk Open
Introduction There is an urgent need to idenfy treatments for COVID-19 that reduce illness duration and hospital admission in those at higher risk of a longer illness course and complications. Methods and analysis The Platform Randomised t…