Aleksandra Nikolić
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View article: Predictors of vaccine hesitancy among medical students at the University of Belgrade
Predictors of vaccine hesitancy among medical students at the University of Belgrade Open
Although medical students generally hold positive attitudes toward vaccination, persistent concerns and misconceptions remain. These findings underscore the need for targeted educational strategies during medical training to strengthen vac…
View article: Transcriptomic Landscape of Paclitaxel-Induced Multidrug Resistance in 3D Cultures of Colon Cancer Cell Line DLD1
Transcriptomic Landscape of Paclitaxel-Induced Multidrug Resistance in 3D Cultures of Colon Cancer Cell Line DLD1 Open
Multidrug resistance (MDR) significantly contributes to colon cancer recurrence, making it essential to understand its molecular basis for improved therapies. This study aimed to identify genes and pathways involved in resistance to standa…
View article: Transcript PHF19-207 May Be a Long Non-Coding RNA with Tumor-Promoting Role in Colon Cancer
Transcript PHF19-207 May Be a Long Non-Coding RNA with Tumor-Promoting Role in Colon Cancer Open
Recent pan-cancer transcriptome analysis has revealed differential activity of two alternative PHF19 gene promoters in malignant versus non-malignant gut mucosa. One of these promoters upregulated in colon cancer leads to the expression of…
View article: Coronary anatomic, functional, and prognostic correlates of ischemic electrocardiographic changes during stress echocardiography
Coronary anatomic, functional, and prognostic correlates of ischemic electrocardiographic changes during stress echocardiography Open
View article: Transcript PHF19-207 as a Potential Biomarker for Colon Cancer Diagnosis and Screening
Transcript PHF19-207 as a Potential Biomarker for Colon Cancer Diagnosis and Screening Open
A recent comprehensive pan-cancer study indicated the high translational potential of the transcript PHF19-207 as a biomarker for colon cancer. This study aimed to analyze the expression of PHF19-207 in colon tissue samples from two differ…
View article: Cone reconstruction after carpentier repair in ebstein anomaly: yes we can!
Cone reconstruction after carpentier repair in ebstein anomaly: yes we can! Open
The management of recurrent tricuspid regurgitation (TR) after initial tricuspid valve (TV) repair in patients with Ebstein's anomaly (EA) represents a complex challenge. Traditionally, tricuspid valve replacement has been the first-line o…
View article: <scp>AKR1B1</scp> Expression in the Colorectal Tumor Microenvironment Contributes Towards Its Prognostic Significance
<span>AKR1B1</span> Expression in the Colorectal Tumor Microenvironment Contributes Towards Its Prognostic Significance Open
Background AKR1B1, a member of the aldo‐keto reductase enzyme family involved in the polyol pathway of aldehyde metabolism, is aberrantly expressed in colorectal cancer (CRC). Our previous studies demonstrated that AKR1B1 knockdown reduced…
View article: Diagnostic Potential of CD44, CD133, and VDR in Epithelial Ovarian Tumors: Association with Histopathology Parameters
Diagnostic Potential of CD44, CD133, and VDR in Epithelial Ovarian Tumors: Association with Histopathology Parameters Open
Cancer stem cells (CSCs) significantly contribute to heterogeneity, malignancy, and therapy resistance in ovarian cancer. Recent studies emphasize the role of the vitamin D receptor (VDR) in regulating cell differentiation and stemness in …
View article: First Transcatheter Valve-in-Valve Implantation With Myval Octacor Into a Failed Biological Prosthetic Aortic Valve in Serbia
First Transcatheter Valve-in-Valve Implantation With Myval Octacor Into a Failed Biological Prosthetic Aortic Valve in Serbia Open
The natural progression of bioprosthetic valve degeneration over time requires further interventions for those experiencing symptomatic prosthesis dysfunction. Transcatheter aortic valve replacement (TAVR) emerges as a promising therapeuti…
View article: Left Ventricular Elastance With Resting Volumetric Transthoracic Echocardiography Identifies Different Phenotypes in Heart Failure With Preserved Ejection Fraction: A Retrospective Analysis of a Multicenter Prospective Observational Study
Left Ventricular Elastance With Resting Volumetric Transthoracic Echocardiography Identifies Different Phenotypes in Heart Failure With Preserved Ejection Fraction: A Retrospective Analysis of a Multicenter Prospective Observational Study Open
View article: Stress Echo 2030 Study: A Flagship Project of the Italian Society of Echocardiography and Cardiovascular Imaging
Stress Echo 2030 Study: A Flagship Project of the Italian Society of Echocardiography and Cardiovascular Imaging Open
Over the past decade, stress echocardiography has evolved from a test for assessing epicardial artery stenosis to a comprehensive functional test, targeting multiple cardiovascular parameters. The new approach includes several structured s…
View article: Matrix metalloproteinase 9 genotype modulates asthma control in pediatric asthma patients
Matrix metalloproteinase 9 genotype modulates asthma control in pediatric asthma patients Open
Matrix metalloproteinases, particularly MMP9, play a pivotal role in asthma pathology by influencing extracellular matrix remodeling and inflammation. This study examined 100 Serbian pediatric asthma patients to explore the correlation bet…
View article: Altered levels of sphingolipid metabolites in serum of locally advanced rectal cancer patients: A pilot study
Altered levels of sphingolipid metabolites in serum of locally advanced rectal cancer patients: A pilot study Open
Background: Altered sphingolipid levels might contribute to rectal cancer development, progression and therapy response by regulating various biological processes, including apoptosis. This study aimed to analyse the serum sphingolipid pro…
View article: Comparative RNA-Seq Analysis of Colon Spheroids and Patient-derived Tissues Identifies Non-Canonical Transcript Isoforms of Protein-Coding Genes Implicated in Colon Carcinogenesis
Comparative RNA-Seq Analysis of Colon Spheroids and Patient-derived Tissues Identifies Non-Canonical Transcript Isoforms of Protein-Coding Genes Implicated in Colon Carcinogenesis Open
Objectives: This study aimed to identify transcript isoforms of protein-coding genes with potential relevance to the malignant transformation of gut mucosa. Methods: Colon cancer cell lines (HCT116, DLD1, SW620) and immortalized cells deri…
View article: The role of ADAM10 in the prediction of neoadjuvant chemoradiotherapy response in patients with locally advanced rectal cancer
The role of ADAM10 in the prediction of neoadjuvant chemoradiotherapy response in patients with locally advanced rectal cancer Open
Protease ADAM10, a member of the A disintegrin and metalloproteinase protein family, plays a role in cytokine/ growth factor release, the shedding of receptor molecules from the membrane, and intracellular signaling. ADAM10 is implicated i…
View article: Left atrial function during exercise stress echocardiography as a sign of paroxysmal/persistent atrial fibrillation
Left atrial function during exercise stress echocardiography as a sign of paroxysmal/persistent atrial fibrillation Open
ESE can complement rest echocardiography in the identification of previous PAF in patients with SR through the evaluation of LA functional reservoir and volume reserve, LV chronotropic, diastolic, and systolic reserve, and RV contractile r…
View article: Markers of Epithelial–Mesenchymal Transition and Mucinous Histology Are Significant Predictors of Disease Severity and Tumor Characteristics in Early-Onset Colorectal Cancer
Markers of Epithelial–Mesenchymal Transition and Mucinous Histology Are Significant Predictors of Disease Severity and Tumor Characteristics in Early-Onset Colorectal Cancer Open
Approximately 20% of patients with colorectal cancer (CRC) are diagnosed with a mucinous subtype of this tumor, have a worse prognosis, and often show resistance to available therapies. Molecules from the mucin family are involved in the r…
View article: Markers of Epithelial-Mesenchymal Transition and Mucinous Histology in Early-Onset Colorectal Cancer
Markers of Epithelial-Mesenchymal Transition and Mucinous Histology in Early-Onset Colorectal Cancer Open
Approximately 20% of patients with colorectal cancer (CRC) are diagnosed with a mucinous subtype of this tumor, have a worse prognosis, and often show resistance to available therapies. Molecules from the mucin family are involved in the r…
View article: 9P Synergistic potential of vitamin D receptor and cancer stem cells markers expression in ovarian tumors
9P Synergistic potential of vitamin D receptor and cancer stem cells markers expression in ovarian tumors Open
Background: Ovarian cancer (OC) is the most aggressive gynecological malignancy. Vitamin D actions mediated by its receptor (VDR) showed significant antitumor activity. Cancer stem cells (CSC) that are characterized by specific surface mar…
View article: P842 Assessment of body composition parameters in patients with inflammatory bowel disease treated with biological therapy
P842 Assessment of body composition parameters in patients with inflammatory bowel disease treated with biological therapy Open
Background There is growing evidence of the role of biological therapy (BT) in improving body composition parameters (BCP) in inflammatory bowel disease (IBD) patients. Since myopenia and high adiposity affect prognosis and could lead to t…
View article: Are We Ready for Climate-Friendly Food Choices? – the Cross-Country Study of Bosnia and Herzegovina, Serbia and Italy
Are We Ready for Climate-Friendly Food Choices? – the Cross-Country Study of Bosnia and Herzegovina, Serbia and Italy Open
View article: P527 Factors associated with choice of treatment regimen after the induction period in patients with Ulcerative Colitis treated with vedolizumab
P527 Factors associated with choice of treatment regimen after the induction period in patients with Ulcerative Colitis treated with vedolizumab Open
Background Vedolizumab (VDZ) is a selective, alpha4-beta7 anti-integrin antibody used for treatment of inflammatory bowel diseases. The aim of our study was to investigate factors that influence the decision making and determine further th…
View article: Dysregulation of transcripts SMAD4-209 and SMAD4-213 and their respective promoters in colon cancer cell lines
Dysregulation of transcripts SMAD4-209 and SMAD4-213 and their respective promoters in colon cancer cell lines Open
Background: The pervasive role of alternative promoters in context-specific isoform expression and the importance of promoter choice over its level of transcriptional activity have been recently implied based on pan-cancer in sil…
View article: How Much Attention Should Be Paid to Urinary Tract Infection in a Patient with Congenital Heart Disease?
How Much Attention Should Be Paid to Urinary Tract Infection in a Patient with Congenital Heart Disease? Open
Background: Tetralogy of Fallot (TOF) is the most common cyanotic Congenital Heart Disease (CHD). As therapy becomes increasingly effective, the number of adults with CHD is growing. There are many surgical options to resolve the pulmonary…
View article: Science on the move - from lab to streets & school (ScienceSCool)
Science on the move - from lab to streets & school (ScienceSCool) Open
“Science on the move - from lab to streets & school” (ScienceSCool) is a two-year project to be
\norganized around the theme "Life in a science bulb (2022)/Life outside the science bulb (2023)"
\nby the Faculty of Physical Ch…
View article: Ebsteins anomaly management in Central and South Eastern European (CESEE) countries: current status and improvement needed
Ebsteins anomaly management in Central and South Eastern European (CESEE) countries: current status and improvement needed Open
Background Ebstein anomaly (EA) of the tricuspid valve (TV) as a rare congenital heart disease (CHD) is characterized by variable morphology, hemodynamics and clinical course, associated heart defects as well. Moreover, whether and when to…
View article: Rare Case of Recurrent Combined Pleural and Pericardial Effusion After CABG: Difficulties in Resolving Due to Bad Socio/Economic Issues and Alcohol Abuse
Rare Case of Recurrent Combined Pleural and Pericardial Effusion After CABG: Difficulties in Resolving Due to Bad Socio/Economic Issues and Alcohol Abuse Open
Pleural effusions are present as a co-finding of lung cancer, heart failure, autoimmune disorders, in surgical practice etc. Pleural effusion is complication regularly seen in post-cardiac surgery patients. It mostly appeared 6 days after …
View article: Serbian Translation and Validation of the SF-36 for the Assessment of Quality of Life in Patients with Diagnosed Arterial Hypertension
Serbian Translation and Validation of the SF-36 for the Assessment of Quality of Life in Patients with Diagnosed Arterial Hypertension Open
Precise estimation of life quality is of special importance in patients with chronic diseases, such as arterial hypertension. There are many questionnaires for that purpose. Short-form 36 (SF-36) with 8 domains has been proved as one of th…
View article: Telemedicine in the Era of a Pandemic: Usefulness of a Novel Three-Lead ECG
Telemedicine in the Era of a Pandemic: Usefulness of a Novel Three-Lead ECG Open
The 12-lead electrocardiogram (ECG) is a first-line diagnostic tool for patients with cardiac symptoms. As observed during the COVID-19 pandemic, the ECG is essential to the initial patient evaluation. The novel KardioPal three-lead-based …
View article: Early Outcomes of a Next-Generation Balloon-Expandable Transcatheter Heart Valve - The Myval System: A Single-Center Experience From Serbia
Early Outcomes of a Next-Generation Balloon-Expandable Transcatheter Heart Valve - The Myval System: A Single-Center Experience From Serbia Open
Transcatheter aortic valve implantation (TAVI) is one of the most effective treatments for severe aortic valve stenosis (AVS). Different genres and generations of transcatheter heart valves (THVs) are accessible, offering operators an oppo…