Explanipedia

Myo‐Inositol Deficiency, Structural Brain Changes, and Cerebral Perfusion Alterations in Classic Galactosemia: Preliminary Insights From a Multiparametric <span>MRI</span> Study Open

Eva Niess, Fabian Niess, Wolfgang Bogner, Alena Svátková, Marion Herle , et al. · 2025

Classic galactosemia is a rare metabolic disorder resulting from galactose‐1‐phosphate uridylyltransferase deficiency, which disrupts normal galactose metabolism, leading to toxic accumulation of galactose‐1‐phosphate and galactitol. Despi…

Diffusion tensor imaging with free‐water correction reveals distinctions between severe and attenuated subtypes in Mucopolysaccharidosis type I Open

Alena Svátková, Ofer Pasternak, Julie B. Eisengart, Kyle Rudser, Petr Bednařík , et al. · 2025

Mucopolysaccharidosis type I (MPS I) is an inherited lysosomal storage disorder leading to deleterious brain effects. While animal models suggested that MPS I severely affects white matter (WM), whole‐brain diffusion tensor imaging (DTI) a…

Evidence-based commentary on the diagnosis, management, and further research of degenerative cervical spinal cord compression in the absence of clinical symptoms of myelopathy Open

Tomáš Horák, Magda Horáková, Miloš Keřkovský, Marek Dostál, Petr Hluštı́k , et al. · 2024

Degenerative cervical myelopathy (DCM) represents the final consequence of a series of degenerative changes in the cervical spine, resulting in cervical spinal canal stenosis and mechanical stress on the cervical spinal cord. This process …

Neuroborreliosis Presenting as Encephalitis: A Case Report Open

Sabina David Ruban, Nanna Skaarup Andersen, Alena Svátková, Christian P. Fischer · 2024

1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain Open

Petr Bednařík, Dario Goranovic, Alena Svátková, Fabian Niess, Lukas Hingerl , et al. · 2023

Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review Open

Jan Valošek, Petr Bednařík, Miloš Keřkovský, Petr Hluštı́k, Josef Bednařík , et al. · 2022

Degenerative spinal cord compression is a frequent pathological condition with increasing prevalence throughout aging. Initial non-myelopathic cervical spinal cord compression (NMDC) might progress over time into potentially irreversible d…

Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review Open

Jan Valošek, Petr Bednařík, Miloš Keřkovský, Petr Hluštı́k, Josef Bednařík , et al. · 2022

Degenerative spinal cord (SC) compression is a frequent pathological condition with increasing prevalence throughout aging. Initial non-myelopathic cervical SC compression (NMDC) might progress over time into potentially irreversible degen…

Semi-automated detection of cervical spinal cord compression with the Spinal Cord Toolbox Open

Magda Horáková, Tomáš Horák, Jan Valošek, Tomáš Rohan, Eva Koriťáková , et al. · 2022

This study demonstrates successful semi-automated compression detection based on four parameters. The inter-trial variability of parameters established through two MRI examinations was conclusively better for Spinal Cord Toolbox compared w…

Different FreeSurfer versions might generate different statistical outcomes in case–control comparison studies Open

Pavel Filip, Petr Bednařík, Lynn E. Eberly, Amir Moheet, Alena Svátková , et al. · 2022

Deuterium labeling enables non-invasive 3D proton MR imaging of glucose and neurotransmitter metabolism in the human brain Open

Petr Bednařík, Dario Goranovic, Alena Svátková, Fabian Niess, Lukas Hingerl , et al. · 2021

Impaired brain glucose metabolism characterizes most severe brain diseases. Recent studies have proposed deuterium (2H)-Magnetic Resonance Spectroscopic Imaging (MRSI) as a reliable, non-invasive, and safe method to quantify the human meta…

<i>In vivo</i> Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression Open

Tomáš Horák, Magda Horáková, Alena Svátková, Zdeněk Kadaňka, Petr Kudlička , et al. · 2021

Degenerative cervical myelopathy (DCM) is a severe consequence of degenerative cervical spinal cord (CSC) compression. The non-myelopathic stage of compression (NMDC) is highly prevalent and often progresses to disabling DCM. This study ai…

Diffusion magnetic resonance imaging reveals tract‐specific microstructural correlates of electrophysiological impairments in non‐myelopathic and myelopathic spinal cord compression Open

Jan Valošek, René Labounek, Tomáš Horák, Magda Horáková, Petr Bednařík , et al. · 2021

Background and purpose Non‐myelopathic degenerative cervical spinal cord compression (NMDC) frequently occurs throughout aging and may progress to potentially irreversible degenerative cervical myelopathy (DCM). Whereas standard clinical m…

Review for "The relationship between white matter microstructure, cardiovascular fitness, gross motor skills, and neurocognitive functioning in children" Open

Alena Svátková · 2021

Effect of Ketamine on Human Neurochemistry in Posterior Cingulate Cortex: A Pilot Magnetic Resonance Spectroscopy Study at 3 Tesla Open

Petr Bednařík, Benjamin Spurny‐Dworak, L. Silberbauer, Alena Svátková, Patricia Handschuh , et al. · 2021

Ketamine is a powerful glutamatergic long-lasting antidepressant, efficient in intractable major depression. Whereas ketamine’s immediate psychomimetic side-effects were linked to glutamate changes, proton MRS ( 1 H-MRS) showed an associat…

Review for "The relationship between white matter microstructure, cardiovascular fitness, gross motor skills, and neurocognitive functioning in children" Open

Alena Svátková · 2020

HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy Open

René Labounek, Jan Valošek, Tomáš Horák, Alena Svátková, Petr Bednařík , et al. · 2020

Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shel…

Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis Open

Pavel Filip, Alena Svátková, Adam F. Carpenter, Lynn E. Eberly, Igor Nestrašil , et al. · 2020

Even though MRI visualization of white matter lesions is pivotal for the diagnosis and management of multiple sclerosis (MS), the issue of detecting diffuse brain tissue damage beyond the apparent T2-hyperintense lesions continues to spark…

Intrathecal enzyme replacement for cognitive decline in mucopolysaccharidosis type I, a randomized, open-label, controlled pilot study Open

Agnes H. Chen, Paul Harmatz, Igor Nestrašil, Julie B. Eisengart, Kelly King , et al. · 2019

White matter measures correlate with essential tremor severity—A pilot diffusion tensor imaging study Open

Igor Nestrašil, Alena Svátková, Kyle Rudser, Ravishankar Chityala, Amy Wakumoto , et al. · 2018

Background An evolving pathophysiological concept of essential tremor ( ET ) points to diffuse brain network involvement, which emphasizes the need to investigate white matter ( WM ) changes associated with motor symptoms of ET . Objective…

Corrigendum: Multi-modal Brain MRI in Subjects with PD and iRBD Open

Silvia Mangia, Alena Svátková, Daniele Mascali, Mikko J. Nissi, Philip Burton , et al. · 2018

[This corrects the article on p. 709 in vol. 11, PMID: 29311789.].

White matter alterations in Parkinson’s disease with normal cognition precede grey matter atrophy Open

Ivan Rektor, Alena Svátková, Ľubomír Vojtíšek, Iva Zikmundová, Jiří Vaníček , et al. · 2018

PD patients without cognitive impairment and GM atrophy demonstrated widespread alterations of WM microstructure. Thus, WM impairment in PD might be a sensitive sign preceding the neuronal loss in associated GM regions.

Multi-modal Brain MRI in Subjects with PD and iRBD Open

Silvia Mangia, Alena Svátková, Daniele Mascali, Mikko J. Nissi, Philip Burton , et al. · 2017

Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a condition that often evolves into Parkinson's disease (PD). Therefore, by monitoring iRBD it is possible to track the neurodegeneration of individuals who may progress to PD…

Intrathecal enzyme replacement therapy reverses cognitive decline in mucopolysaccharidosis type I Open

Igor Nestrašil, Elsa Shapiro, Alena Svátková, Patricia Dickson, Agnes Chen , et al. · 2017

Mucopolysaccharidosis type I (MPS I) is an inherited lysosomal storage disease that seriously affects the brain. Severity of neurocognitive symptoms in attenuated MPS subtype (MPS IA) broadly varies partially, due to restricted permeabilit…

Unique white matter microstructural patterns in ADHD presentations—a diffusion tensor imaging study Open

Alena Svátková, Igor Nestrašil, Kyle Rudser, Jodene Goldenring Fine, Jesse Bledsoe , et al. · 2016

Attention‐deficit/hyperactivity disorder predominantly inattentive (ADHD‐PI) and combined (ADHD‐C) presentations are likely distinct disorders that differ neuroanatomically, neurochemically, and neuropsychologically. However, to date, litt…

Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls Open

Alena Svátková, René C.W. Mandl, Thomas W. Scheewe, Wiepke Cahn, René S. Kahn , et al. · 2015

It has been shown that learning a new skill leads to structural changes in the brain. However, it is unclear whether it is the acquisition or continuous practicing of the skill that causes this effect and whether brain connectivity of pati…

Alena Svátková YOU? Author Swipe