Alessandra Aldieri
YOU?
Author Swipe
View article: Assessing the Impact of Morphological Parameters on the Mechanical Behavior of Synthetic Meshes. A Multivariate Regression Approach
Assessing the Impact of Morphological Parameters on the Mechanical Behavior of Synthetic Meshes. A Multivariate Regression Approach Open
The impact of morphological and mechanical parameters of surgical meshes on the healing processes and patient comfort after abdominal repair surgery is widely accepted. However, how the structure of the knitted pattern of synthetic meshes …
View article: Can Multi‐Vertebral CT‐Based Finite Element Models Accurately Predict Strains? An In Vitro Validation Study
Can Multi‐Vertebral CT‐Based Finite Element Models Accurately Predict Strains? An In Vitro Validation Study Open
Many proposed FE models to predict the vertebral risk of fracture consider single vertebrae only, neglecting the role of the intervertebral discs in load transmission and distribution across vertebrae. Inclusion of the intervertebral discs…
View article: Exploring the association between coronary vascular anatomical features and future myocardial infarction through statistical shape modelling
Exploring the association between coronary vascular anatomical features and future myocardial infarction through statistical shape modelling Open
Considering the intricate interplay among coronary anatomy and hemodynamics in coronary artery disease (CAD), anatomy-based descriptors have been employed as surrogates of local aberrant hemodynamics and, ultimately, as clinical markers fo…
View article: Comparing the predictions of CT-based subject-specific finite element models of human metastatic vertebrae with digital volume correlation measurements
Comparing the predictions of CT-based subject-specific finite element models of human metastatic vertebrae with digital volume correlation measurements Open
Several conditions can increase the incidence of vertebral fragility fractures, including metastatic bone disease. Computational tools could help clinicians estimate the risk of vertebral fracture in these patients; however, comparison wit…
View article: Position Paper: Extending Credibility Assessment of In Silico Medicine Predictors to Machine Learning Predictors
Position Paper: Extending Credibility Assessment of In Silico Medicine Predictors to Machine Learning Predictors Open
There are several situations where it would be convenient if a quantity of interest essential to support a medical or regulatory decision could be predicted as a function of other measurable quantities rather than measured experimentally. …
View article: Consensus statement on the credibility assessment of machine learning predictors
Consensus statement on the credibility assessment of machine learning predictors Open
The rapid integration of machine learning (ML) predictors into in silico medicine has revolutionized the estimation of quantities of interest that are otherwise challenging to measure directly. However, the credibility of these predictors …
View article: Consensus statement on the credibility assessment of ML predictors
Consensus statement on the credibility assessment of ML predictors Open
The rapid integration of machine learning (ML) predictors into in silico medicine has revolutionized the estimation of quantities of interest (QIs) that are otherwise challenging to measure directly. However, the credibility of these predi…
View article: Phantomless calibration of CT scans for hip fracture risk prediction in silico: Comparison with phantom-based calibration
Phantomless calibration of CT scans for hip fracture risk prediction in silico: Comparison with phantom-based calibration Open
Finite element models built from quantitative computed tomography images rely on element-wise mapping of material properties starting from Hounsfield Units (HU), which can be converted into mineral densities upon calibration. While calibra…
View article: A statistical shape analysis for the assessment of the main geometrical features of the distal femoral medullary canal
A statistical shape analysis for the assessment of the main geometrical features of the distal femoral medullary canal Open
Statistical Shape Models (SSMs) are widely used in orthopedics to extract the main shape features from bone regions (e.g., femur). This study aims to develop an SSM of the femoral medullary canal, investigate its anatomical variability, an…
View article: Effects of Fluconazole Discontinuation on the Pharmacokinetics of Immunosuppression in Pediatric Heart Transplant Recipients
Effects of Fluconazole Discontinuation on the Pharmacokinetics of Immunosuppression in Pediatric Heart Transplant Recipients Open
View article: Development and validation of a semi-automated and unsupervised method for femur segmentation from CT
Development and validation of a semi-automated and unsupervised method for femur segmentation from CT Open
View article: DXA-based statistical models of shape and intensity outperform aBMD hip fracture prediction: A retrospective study
DXA-based statistical models of shape and intensity outperform aBMD hip fracture prediction: A retrospective study Open
Areal bone mineral density (aBMD) currently represents the clinical gold standard for hip fracture risk assessment. Nevertheless, it is characterised by a limited prediction accuracy, as about half of the people experiencing a fracture are…
View article: Multi-vertebral CT-based FE models implementing linear isotropic population-based material properties for the intervertebral discs cannot accurately predict strains
Multi-vertebral CT-based FE models implementing linear isotropic population-based material properties for the intervertebral discs cannot accurately predict strains Open
Vertebral fractures prediction in clinics lacks of accuracy. The most used scores have limitations in distinguishing between subjects at risk or not. Finite element (FE) models generated from computed tomography (CT) of these patients may …
View article: Validation of homogenized finite element models of human metastatic vertebrae using digital volume correlation
Validation of homogenized finite element models of human metastatic vertebrae using digital volume correlation Open
The incidence of vertebral fragility fracture is increased by the presence of preexisting pathologies such as metastatic disease. Computational tools could support the fracture prediction and consequently the decision of the best medical t…
View article: Credibility assessment of computational models according to ASME V&V40: Application to the Bologna Biomechanical Computed Tomography solution
Credibility assessment of computational models according to ASME V&V40: Application to the Bologna Biomechanical Computed Tomography solution Open
This work provides the practical application of the ASME V&V40-2018 risk-based credibility assessment framework, which could be applied to demonstrate model credibility in any field and support future regulatory submissions and foster the …
View article: Experimental validation of a subject-specific finite element model of lumbar spine segment using digital image correlation
Experimental validation of a subject-specific finite element model of lumbar spine segment using digital image correlation Open
Pathologies such as cancer metastasis and osteoporosis strongly affect the mechanical properties of the vertebral bone and increase the risk of fragility fractures. The prediction of the fracture risk with a patient-specific model, directl…
View article: Toward A Regulatory Pathway for the Use of in Silico Trials in the CE Marking of Medical Devices
Toward A Regulatory Pathway for the Use of in Silico Trials in the CE Marking of Medical Devices Open
In Silico Trials methodologies will play a growing and fundamental role in the development and de-risking of new medical devices in the future. While the regulatory pathway for Digital Patient and Personal Health Forecasting solutions is c…
View article: DXA-Based Finite Element Analysis as Support for Pre and Post-operative Evaluation of Hip Arthroplasty
DXA-Based Finite Element Analysis as Support for Pre and Post-operative Evaluation of Hip Arthroplasty Open
View article: Personalised 3D Assessment of Trochanteric Soft Tissues Improves HIP Fracture Classification Accuracy
Personalised 3D Assessment of Trochanteric Soft Tissues Improves HIP Fracture Classification Accuracy Open
Passive soft tissues surrounding the trochanteric region attenuate fall impact forces and thereby control hip fracture risk. The degree of attenuation is related to Soft Tissue Thickness (STT). STT at the neutral hip impact orientation, es…
View article: Improving the Hip Fracture Risk Prediction with a Statistical Shape-and-Intensity Model of the Proximal Femur
Improving the Hip Fracture Risk Prediction with a Statistical Shape-and-Intensity Model of the Proximal Femur Open
Severe predictions have been made regarding osteoporotic fracture incidence for the next years, with major economic and social impacts in a worldwide greying society. However, the performance of the currently adopted gold standard for frac…
View article: Stochastic PCA-Based Bone Models from Inverse Transform Sampling: Proof of Concept for Mandibles and Proximal Femurs
Stochastic PCA-Based Bone Models from Inverse Transform Sampling: Proof of Concept for Mandibles and Proximal Femurs Open
Principal components analysis is a powerful technique which can be used to reduce data dimensionality. With reference to three-dimensional bone shape models, it can be used to generate an unlimited number of models, defined by thousands of…
View article: Feature-Based Modelling of Laryngoscope Blades for Customized Applications
Feature-Based Modelling of Laryngoscope Blades for Customized Applications Open
Laryngoscopes are used as diagnostic devices for throat inspection or as an aid to intubation. Their blade must be geometrically compatible with patients’ anatomy to provide a good view to doctors with minimal discomfort to patients. For t…
View article: Finite Element Modeling Application in Forensic Practice: A Periprosthetic Femoral Fracture Case Study
Finite Element Modeling Application in Forensic Practice: A Periprosthetic Femoral Fracture Case Study Open
The incidence of periprosthetic fractures has rapidly increased in the last two decades and has been the cause of a large number of revision surgeries and permanent physical disability for many patients, as well as a significant socioecono…
View article: Decellularized Human Dermal Matrix as a Biological Scaffold for Cardiac Repair and Regeneration
Decellularized Human Dermal Matrix as a Biological Scaffold for Cardiac Repair and Regeneration Open
The complex and highly organized environment in which cells reside consists primarily of the extracellular matrix (ECM) that delivers biological signals and physical stimuli to resident cells. In the native myocardium, the ECM contributes …
View article: Development of an animal-free methodology for mechanical performance assessment of engineered skin substitutes
Development of an animal-free methodology for mechanical performance assessment of engineered skin substitutes Open
Functional substitutes for the treatment of skin wounds are nowadays widely available thanks to the progress in skin tissue engineering. However, the performance of the existing substitutes in terms of mechanical behavior, which is a deter…
View article: Improving the Hip Fracture Risk Prediction Through 2D Finite Element Models From DXA Images: Validation Against 3D Models
Improving the Hip Fracture Risk Prediction Through 2D Finite Element Models From DXA Images: Validation Against 3D Models Open
Osteoporotic fracture incidence represents a major social and economic concern in the modern society, where the progressive graying of the population involves an highly increased fracture occurrence. Although the gold standard to diagnose …
View article: Native human dermis versus human acellular dermal matrix: A comparison of biaxial mechanical properties
Native human dermis versus human acellular dermal matrix: A comparison of biaxial mechanical properties Open
Background
\nHuman Acellular Dermal Matrices (HADMs), thanks to its mechanical resistance and it’s not immunogenic response, is used in reconstructive surgery such as breast reconstruction procedures and hernia repairs. There is the need t…
View article: A CONSTITUTIVE FRAMEWORK FOR HUMAN DERMIS MECHANICAL MODELLING
A CONSTITUTIVE FRAMEWORK FOR HUMAN DERMIS MECHANICAL MODELLING Open
Finite element models, in conjunction with adequate constitutive relations of the materials involved, have proved to be crucial in many medical applications, such as in surgical planning.Nevertheless, a thorough numerical analysis of dermi…
View article: EQUI-BIAXIAL TESTS FOR MECHANICAL CHARACTERIZATION OF HUMAN ACELLULAR DERMAL MATRICES THROUGH A CUSTOM-MADE BIAXIAL FIXTURE
EQUI-BIAXIAL TESTS FOR MECHANICAL CHARACTERIZATION OF HUMAN ACELLULAR DERMAL MATRICES THROUGH A CUSTOM-MADE BIAXIAL FIXTURE Open
Human Acellular Dermal Matrices (HADMs) have recently been employed in reconstructive surgeries which involve high mechanical resistance prerequisites (e.g.rotator cuff tears repair, Achilles tendon augmentation, breast reconstruction proc…
View article: DERMIS CONSTITUTIVE MODEL IDENTIFICATION FROMEXPERIMENTAL STRAIN DISTRIBUTION. Abstracts from the National Biomaterial Congress - SIB, 24-26 May 2017, Milan, Italy
DERMIS CONSTITUTIVE MODEL IDENTIFICATION FROMEXPERIMENTAL STRAIN DISTRIBUTION. Abstracts from the National Biomaterial Congress - SIB, 24-26 May 2017, Milan, Italy Open