Alessandra Bolsi
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View article: First clinical implementation of a highly efficient daily online adapted proton therapy (DAPT) workflow
First clinical implementation of a highly efficient daily online adapted proton therapy (DAPT) workflow Open
Objective. This study presents the first clinical implementation of an efficient online daily adaptive proton therapy workflow (DAPT). Approach. The DAPT workflow includes a pre-treatment phase, where a template and a fallback plan are opt…
View article: A bi-directional beam-line energy ramping for efficient patient treatment with scanned proton therapy
A bi-directional beam-line energy ramping for efficient patient treatment with scanned proton therapy Open
Objective. The treatment of mobile tumours using Pencil Beam Scanning (PBS) has become more prevalent in the last decade. However, to achieve the same beam delivery quality as for static tumours, treatments have to be combined with motion …
View article: Long Term Outcome and Quality of Life of Intracranial Meningioma Patients Treated with Pencil Beam Scanning Proton Therapy
Long Term Outcome and Quality of Life of Intracranial Meningioma Patients Treated with Pencil Beam Scanning Proton Therapy Open
The aim of this study was to assess the clinical outcome, including QoL, of patients with intracranial meningiomas WHO grade 1–3 who were treated with Pencil Beam Scanning Proton Therapy (PBS PT) between 1997 and 2022. Two hundred patients…
View article: RONC-02. Clinical outcome after craniospinal irradiation with pencil beam scanning proton therapy for children and young adults/adolescents with brain tumors
RONC-02. Clinical outcome after craniospinal irradiation with pencil beam scanning proton therapy for children and young adults/adolescents with brain tumors Open
BACKGROUND: Craniospinal irradiation (CSI) is an essential treatment component to achieve cure for some brain tumors in children and young adults/adolescents (C-AYAs). Multimodal treatment approaches are however associated with treatment-r…
View article: Influence of Radiation Dose, Photon Energy, and Reconstruction Kernel on rho/z Analysis in Spectral Computer Tomography: A Phantom Study
Influence of Radiation Dose, Photon Energy, and Reconstruction Kernel on rho/z Analysis in Spectral Computer Tomography: A Phantom Study Open
DECT comprises a feasible method for the extraction of material-specific information. Slight variations should be taken into account when different radiation doses, photon energies, and kernels are applied; however, they are considered sma…
View article: Effects of deep inspiration breath hold on prone photon or proton irradiation of breast and regional lymph nodes
Effects of deep inspiration breath hold on prone photon or proton irradiation of breast and regional lymph nodes Open
We report on a comparative dosimetrical study between deep inspiration breath hold (DIBH) and shallow breathing (SB) in prone crawl position for photon and proton radiotherapy of whole breast (WB) and locoregional lymph node regions, inclu…
View article: Proton Therapy for Intracranial Meningioma for the Treatment of Primary/Recurrent Disease Including Re-Irradiation
Proton Therapy for Intracranial Meningioma for the Treatment of Primary/Recurrent Disease Including Re-Irradiation Open
Meningeal tumors represent approximately 10–25% of primary brain tumors and occur usually in elderly female patients. Most meningiomas are benign (80–85%) and for symptomatic and/or large tumors, surgery, with or without radiation therapy …
View article: Comparison Between Deep Inspiration Breath Hold and Shallow Breathing for Prone Photon or Proton Irradiation of the Breast and Regional Lymph Nodes
Comparison Between Deep Inspiration Breath Hold and Shallow Breathing for Prone Photon or Proton Irradiation of the Breast and Regional Lymph Nodes Open
We report on a comparative dosimetrical study between deep inspiration breath hold (DIBH) and shallow breathing (SB) in prone crawl position for photon and proton radiotherapy of whole breast (WB) and locoregional lymph node regions, inclu…
View article: Prognostic factors for spinal chordomas and chondrosarcomas treated with postoperative pencil-beam scanning proton therapy: a large, single-institution experience
Prognostic factors for spinal chordomas and chondrosarcomas treated with postoperative pencil-beam scanning proton therapy: a large, single-institution experience Open
OBJECTIVE The aim of this paper was to evaluate the prognostic factors in surgical and adjuvant care for spinal chordomas and chondrosarcomas after surgery followed by high-dose pencil-beam scanning proton therapy (PBS-PT). METHODS From 19…
View article: Radiation-induced optic neuropathy after pencil beam scanning proton therapy for skull-base and head and neck tumours
Radiation-induced optic neuropathy after pencil beam scanning proton therapy for skull-base and head and neck tumours Open
Objective: To assess the radiation-induced optic neuropathy (RION) prevalence, following high dose pencil beam scanning proton therapy (PBSPT) to skull base and head and neck (H&N) tumours Methods: Between 1999 and 2014, 216 adult patients…
View article: Proton therapy for brain tumours in the area of evidence-based medicine
Proton therapy for brain tumours in the area of evidence-based medicine Open
Proton therapy (PT) has been administered for many years to a number of cancers, including brain tumours. Due to their remarkable physical properties, delivering their radiation to a very precise brain volume with no exit dose, protons are…
View article: Early results and volumetric analysis after spot-scanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas
Early results and volumetric analysis after spot-scanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas Open
Objective: Large inoperable sacral chordomas show unsatisfactory local control rates even when treated with high dose proton therapy (PT). The aim of this study is assessing feasibility and reporting early results of patients treated with …
View article: Evaluation of the ray-casting analytical algorithm for pencil beam scanning proton therapy
Evaluation of the ray-casting analytical algorithm for pencil beam scanning proton therapy Open
For pencil beam scanned (PBS) proton therapy, analytical dose calculation engines are still typically used for the optimisation process, and often for the final evaluation of the plan. Recently however, the suitability of analytical calcul…