Alessandra Giorgi
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View article: Ferritin‐based disruptor nanoparticles: A novel strategy to enhance <scp>LDL</scp> cholesterol clearance via multivalent inhibition of <scp>PCSK9</scp>–<scp>LDL</scp> receptor interaction
Ferritin‐based disruptor nanoparticles: A novel strategy to enhance <span>LDL</span> cholesterol clearance via multivalent inhibition of <span>PCSK9</span>–<span>LDL</span> receptor interaction Open
Hypercholesterolemia, characterized by elevated low‐density lipoprotein (LDL) cholesterol levels, is a significant risk factor for cardiovascular disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a crucial role in choles…
View article: Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1
Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1 Open
View article: β-Hexachlorocyclohexane triggers neuroinflammatory activity, epigenetic histone post-translational modifications and cognitive dysfunction
β-Hexachlorocyclohexane triggers neuroinflammatory activity, epigenetic histone post-translational modifications and cognitive dysfunction Open
Persistent organic pollutants (POPs), which encompass pesticides and industrial chemicals widely utilized across the globe, pose a covert threat to human health. β-hexachlorocyclohexane (β-HCH) is an organochlorine pesticide with striking …
View article: Ferritin nanocage-enabled detection of pathological tau in living human retinal cells
Ferritin nanocage-enabled detection of pathological tau in living human retinal cells Open
View article: A cross-cultural analysis of the gestural pattern of surprise and surprise-disapproval questions
A cross-cultural analysis of the gestural pattern of surprise and surprise-disapproval questions Open
In this article, we address the issue concerning the gestural patterns in expressing surprise and disapproval across various languages and cultures. The results obtained so far point to an interesting, and in a sense rather surprising, uni…
View article: Combined Delivery of miR-15/16 through Humanized Ferritin Nanocages for the Treatment of Chronic Lymphocytic Leukemia
Combined Delivery of miR-15/16 through Humanized Ferritin Nanocages for the Treatment of Chronic Lymphocytic Leukemia Open
Chronic lymphocytic leukemia (CLL) is a widespread type of leukemia that predominantly targets B lymphocytes, undermining the balance between cell proliferation and apoptosis. In healthy B cells, miR-15/16, a tandem of microRNAs, functions…
View article: Ferritin Nanocage-Enabled Detection of Pathological Tau in Living Human Retinal Cells
Ferritin Nanocage-Enabled Detection of Pathological Tau in Living Human Retinal Cells Open
Background Tauopathies, such as Alzheimer's disease and Frontotemporal Dementia, are debilitating neurodegenerative disorders characterized by cognitive decline. Despite extensive research, effective treatments and significant advancements…
View article: Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase
Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase Open
Adequate levels of pyridoxal 5′‐phosphate (PLP), the catalytically active form of vitamin B 6 , and its proper distribution in the body are essential for human health. The PLP recycling pathway plays a crucial role in these processes and i…
View article: Rab11A Depletion in Microglia-Derived Extracellular Vesicle Proteome upon Beta-Amyloid Treatment
Rab11A Depletion in Microglia-Derived Extracellular Vesicle Proteome upon Beta-Amyloid Treatment Open
View article: Proteomic characterization of extracellular vesicles released by third stage larvae of the zoonotic parasite Anisakis pegreffii (Nematoda: Anisakidae)
Proteomic characterization of extracellular vesicles released by third stage larvae of the zoonotic parasite Anisakis pegreffii (Nematoda: Anisakidae) Open
Introduction Anisakis pegreffii is a sibling species within the A. simplex (s.l.) complex requiring marine homeothermic (mainly cetaceans) and heterothermic (crustaceans, fish, and cephalopods) organisms to complete its life cycle. It is a…
View article: Structural Characterization of Murine Phosphodiesterase 5 Isoforms and Involvement of Cysteine Residues in Supramolecular Assembly
Structural Characterization of Murine Phosphodiesterase 5 Isoforms and Involvement of Cysteine Residues in Supramolecular Assembly Open
Phosphodiesterases (PDEs) are a superfamily of evolutionarily conserved cyclic nucleotide (cAMP/cGMP)-hydrolyzing enzymes, components of transduction pathways regulating crucial aspects of cell life. Within this family, the cGMP-dependent …
View article: Multicomponent Synthesis of Diaminopurine and Guanine PNA’s Analogues Active against Influenza A Virus from Prebiotic Compounds
Multicomponent Synthesis of Diaminopurine and Guanine PNA’s Analogues Active against Influenza A Virus from Prebiotic Compounds Open
Peptide nucleic acids (PNAs) play a key role in prebiotic chemistry as a chimera between RNA and proteins. We developed an alternative synthesis of bioactive PNA's diaminopurine and guanine analogues from prebiotic compounds, such as amino…
View article: Modulation of Virulence-Associated Traits in Aspergillus fumigatus by BET Inhibitor JQ1
Modulation of Virulence-Associated Traits in Aspergillus fumigatus by BET Inhibitor JQ1 Open
Aspergillus fumigatus is a disease-causing, opportunistic fungus that can establish infection due to its capacity to respond to a wide range of environmental conditions. Secreted proteins and metabolites, which play a critical role in fung…
View article: Characterization of the <scp><i>Escherichia coli</i></scp> pyridoxal 5′‐phosphate homeostasis protein (<scp>YggS</scp>): Role of lysine residues in <scp>PLP</scp> binding and protein stability
Characterization of the <span><i>Escherichia coli</i></span> pyridoxal 5′‐phosphate homeostasis protein (<span>YggS</span>): Role of lysine residues in <span>PLP</span> binding and protein stability Open
The pyridoxal 5′‐phosphate (PLP) homeostasis protein (PLPHP) is a ubiquitous member of the COG0325 family with apparently no catalytic activity. Although the actual cellular role of this protein is unknown, it has been observed that mutati…
View article: Rab11A depletion in microglia-derived extracellular vesicle proteome upon beta-amyloid treatment
Rab11A depletion in microglia-derived extracellular vesicle proteome upon beta-amyloid treatment Open
Microglia, the macrophage-like glial cells, behave as sentinels against exogenous pathogens invading the neural tissue. Their commitment is not only confined to the defensive function, but they also perform balancing trophic activities suc…
View article: Homocysteinylated alpha 1 antitrypsin as an antigenic target of autoantibodies in seronegative rheumatoid arthritis patients
Homocysteinylated alpha 1 antitrypsin as an antigenic target of autoantibodies in seronegative rheumatoid arthritis patients Open
View article: Primitive RNA-catalysis with guanine-rich oligonucleotide sequences – the case of a (GGC)<sub>3</sub>nonamer
Primitive RNA-catalysis with guanine-rich oligonucleotide sequences – the case of a (GGC)<sub>3</sub>nonamer Open
A cornerstone of molecular evolution leading to the emergence of life on our planet is associated with appearance of the first catalytic RNA molecules. A question remains regarding the nature of the simplest catalytic centers that could me…
View article: The Comparative Method in Synchronic Linguistics: The Case of Word Order
The Comparative Method in Synchronic Linguistics: The Case of Word Order Open
In this article I discuss the comparative method in formal linguistics when applied to word order phenomena in Italian, English and German. I argue that the comparison has to rest on sound theoretical basis in order to reach interesting co…
View article: One- and Two-Electron Oxidations of β-Amyloid25-35 by Carbonate Radical Anion (CO3•−) and Peroxymonocarbonate (HCO4−): Role of Sulfur in Radical Reactions and Peptide Aggregation
One- and Two-Electron Oxidations of β-Amyloid25-35 by Carbonate Radical Anion (CO3•−) and Peroxymonocarbonate (HCO4−): Role of Sulfur in Radical Reactions and Peptide Aggregation Open
The β-amyloid (Aβ) peptide plays a key role in the pathogenesis of Alzheimer’s disease. The methionine (Met) residue at position 35 in Aβ C-terminal domain is critical for neurotoxicity, aggregation, and free radical formation initiated by…
View article: A Probiotic Preparation Hydrolyzes Gliadin and Protects Intestinal Cells from the Toxicity of Pro-Inflammatory Peptides
A Probiotic Preparation Hydrolyzes Gliadin and Protects Intestinal Cells from the Toxicity of Pro-Inflammatory Peptides Open
Celiac disease (CD) is an autoimmune enteropathy caused by an intolerance to gluten proteins. It has been hypothesized that probiotic bacteria may exert beneficial effects by modulating inflammatory processes and by sustaining peptide hydr…
View article: Proteomic Analysis of Quercetin-Treated K562 Cells
Proteomic Analysis of Quercetin-Treated K562 Cells Open
Among natural products under investigation for their additive potential in cancer prevention and treatment, the flavonoid quercetin has received attention for its effects on the cell cycle arrest and apoptosis. In the past, we addressed th…
View article: Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases
Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases Open
Diabetes mellitus is one of the major risk factors for cognitive dysfunction. The pathogenesis of brain impairment caused by chronic hyperglycemia is complex and includes mitochondrial dysfunction, neuroinflammation, neurotransmitters' alt…
View article: STAT3 Post-Translational Modifications Drive Cellular Signaling Pathways in Prostate Cancer Cells
STAT3 Post-Translational Modifications Drive Cellular Signaling Pathways in Prostate Cancer Cells Open
STAT3 is an oncoprotein overexpressed in different types of tumors, including prostate cancer (PCa), and its activity is modulated by a variety of post-translational modifications (PTMs). Prostate cancer represents the most common cancer d…
View article: Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation
Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation Open
The aberrant activation of hedgehog (HH) signaling is a leading cause of the development of medulloblastoma, a pediatric tumor of the cerebellum. The FDA‑approved HH inhibitor, Vismodegib, which targets the transmembrane transducer SMO, ha…
View article: An Evaluative Head in Romance
An Evaluative Head in Romance Open
In this work, we analyse the behaviour of a verbal suffix in Palermitan – the Romance language spoken in Palermo, Sicily – expressing an evaluative meaning with sentential scope. The suffix is (V)vu, where V is the thematic vowel of the ve…
View article: <i>Ma non era rosso?</i> (But wasn’t it red?)
<i>Ma non era rosso?</i> (But wasn’t it red?) Open
In this article I investigate the properties of counter-expectational surprise yes-no questions in Italian, introduced by the adversative particle ma . These structures minimally contrast with surprise exclamations. I provide an analysis o…
View article: Indirect reports in Modern Eastern Armenian
Indirect reports in Modern Eastern Armenian Open
View article: COMPARATIVE 1D- AND 2D-ELECTROPHORETIC PROTEIN PROFILES OF ANCESTRAL AND MODERN BUCKWHEAT SEEDS GROWN IN THE ITALIAN ALPINE REGION
COMPARATIVE 1D- AND 2D-ELECTROPHORETIC PROTEIN PROFILES OF ANCESTRAL AND MODERN BUCKWHEAT SEEDS GROWN IN THE ITALIAN ALPINE REGION Open
Buckwheat is an old crop whose seeds protein composition candidates these under-utilised seeds as much needed ingredients for the production of gluten-free products. Several buckwheat species and local cultivars are known worldwide. In thi…
View article: Discourse, sentence grammar and the left periphery of the clause
Discourse, sentence grammar and the left periphery of the clause Open
View article: Il verbo secondo in armeno orientale moderno
Il verbo secondo in armeno orientale moderno Open