Alessandra Greco
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View article: Long-Term Cardiovascular Toxicity of Immunotherapy: Too Important to Ignore
Long-Term Cardiovascular Toxicity of Immunotherapy: Too Important to Ignore Open
Immunotherapy improved survival in a significant number of cancer patients as never before. Its benefits spread across cancer types and stages, and new drugs, new combination, and new indications are on the way. Both atherosclerosis and ca…
View article: Pulmonary Arterial Hypertension Onset in an Adult Woman With a <scp><i>TBX4</i></scp> Likely Pathogenic Variant Following Imatinib Administration: A Case Report
Pulmonary Arterial Hypertension Onset in an Adult Woman With a <span><i>TBX4</i></span> Likely Pathogenic Variant Following Imatinib Administration: A Case Report Open
The TBX4 gene has a critical importance in the development of the lower limbs and lungs. Pathogenic variants in this gene are associated with a variable spectrum of skeletal anomalies of the lower limb and pneumological manifestations, wit…
View article: SGLT2 Inhibitors in Cancer Patients: A Comprehensive Review of Clinical, Biochemical, and Therapeutic Implications in Cardio-Oncology
SGLT2 Inhibitors in Cancer Patients: A Comprehensive Review of Clinical, Biochemical, and Therapeutic Implications in Cardio-Oncology Open
Patients with active cancer and cancer survivors are at a markedly increased risk for developing cardiovascular comorbidities, including heart failure, coronary artery disease, and renal dysfunction, which are often compounded by the cardi…
View article: Cardiac physiologic pacing in Pediatrics: the new alternative of cardiac stimulation
Cardiac physiologic pacing in Pediatrics: the new alternative of cardiac stimulation Open
Introduction Conduction physiological pacing (CPP), stimulating the bundle of His or the left bundle branch (LBBP), allows physiological activation of both ventricles. Studies in adults have shown improvement in electrical and mechanical d…
View article: Revolutionizing physical activity in athletes at risk of sudden cardiac death: PAC-SAMS project in Spain
Revolutionizing physical activity in athletes at risk of sudden cardiac death: PAC-SAMS project in Spain Open
Introduction Inhereted arrhythmia syndromes in young athletes (Spanish abbreviation SAMS "sindromes asociados a la muerte subita) carry a high risk of cardiac events during adrenergic activity, leading to restrictions on competitive physic…
View article: Impact of tricuspid regurgitation on right ventricular myocardial work in patients with pulmonary hypertension: a pilot study
Impact of tricuspid regurgitation on right ventricular myocardial work in patients with pulmonary hypertension: a pilot study Open
Aim: Significant tricuspid regurgitation (TR) may be a confounding factor when assessing right ventricular (RV) function with imaging techniques. Global myocardial work (GMW) has been proposed as a non-invasive surrogate of RV pressure–vol…
View article: Glucagon-like Peptide 1 Receptor Agonists in Cardio-Oncology: Pathophysiology of Cardiometabolic Outcomes in Cancer Patients
Glucagon-like Peptide 1 Receptor Agonists in Cardio-Oncology: Pathophysiology of Cardiometabolic Outcomes in Cancer Patients Open
Cancer patients, especially long cancer survivors, are exposed to several cardio-metabolic diseases, including diabetes, heart failure, and atherosclerosis, which increase their risk of cardiovascular mortality. Therapy with glucagon-like …
View article: Dapagliflozin for the primary prevention of chemotherapy induced cardiotoxicity in breast cancer patients treated with neo-adjuvant anthracycline-based chemotherapy: design of the multi-center phase II randomized PROTECT trial
Dapagliflozin for the primary prevention of chemotherapy induced cardiotoxicity in breast cancer patients treated with neo-adjuvant anthracycline-based chemotherapy: design of the multi-center phase II randomized PROTECT trial Open
Background: Their clinical effectiveness of anthracyclines may be thwarted by the development of cardiotoxicity progressively leading to heart failure (HF) and compromising the quality of life and overall survival of breast cancer (BC) pat…
View article: Hepatic arterial infusion chemotherapy: a review with technical notes
Hepatic arterial infusion chemotherapy: a review with technical notes Open
Combined hepatic artery infusion (HAI) and systemic chemotherapy have demonstrated its clinical efficacy in prolonging overall survival in unresectable intrahepatic cholangiocarcinoma and as a conversion to treatment strategy in a small pr…
View article: Cancer incidence in immigrants by geographical area of origin: data from the Veneto Tumour Registry, Northeastern Italy
Cancer incidence in immigrants by geographical area of origin: data from the Veneto Tumour Registry, Northeastern Italy Open
Objective We investigated whether there are differences in cancer incidence by geographical area of origin in North-eastern Italy. Methods We selected all incident cases recorded in the Veneto Tumour Registry in the period 2015-2019. Subje…
View article: Prognostic value of deep echocardiographic phenotyping in pulmonary arterial hypertension
Prognostic value of deep echocardiographic phenotyping in pulmonary arterial hypertension Open
Background A novel approach to derive prognostic information from echocardiography in pulmonary arterial hypertension (PAH) is to define a phenotype of right heart function combining standard echocardiographic parameters which describe rig…
View article: Single-lead ECGs: the future of home-monitoring in neonatal supraventricular tachycardias
Single-lead ECGs: the future of home-monitoring in neonatal supraventricular tachycardias Open
Funding Acknowledgements Type of funding sources: None. Background Supraventricular tachycardia (SVT) is the most common tachyarrhythmia in the neonatal period. Prevalence has not been fully established (up to 1 in 1000 children) and incid…
View article: Impact of cardiac sympathetic denervation on electrical storms in patients with cardiomyopathies
Impact of cardiac sympathetic denervation on electrical storms in patients with cardiomyopathies Open
Funding Acknowledgements Type of funding sources: None. Background Cardiac Sympathetic Denervation (CSD) has been recently proposed for the treatment of refractory ventricular arrhythmias (VAs) in patients with cardiomyopathy (CMP). A mult…
View article: C3 OUTCOME OF CARDIAC SYMPATHETIC DENERVATION IN CARDIOMYOPATHIES AND PREDICTORS OF RECURRENCES
C3 OUTCOME OF CARDIAC SYMPATHETIC DENERVATION IN CARDIOMYOPATHIES AND PREDICTORS OF RECURRENCES Open
Background Cardiac Sympathetic Denervation (CSD) has been recently proposed for the treatment of refractory ventricular arrhythmias (VAs) in patients with cardiomyopathy (CMP). Long–term outcome and predictors of recurrences after the proc…
View article: Quality control on digital cancer registration
Quality control on digital cancer registration Open
Population-based cancer registration methods are subject to internationally-established rules. To ensure efficient and effective case recording, population-based cancer registries widely adopt digital processing (DP) methods. At the Veneto…
View article: 958 IMPACT OF CARDIAC SYMPATHETIC DENERVATION ON ELECTRICAL STORMS IN PATIENTS WITH CARDIOMIOPATHIES
958 IMPACT OF CARDIAC SYMPATHETIC DENERVATION ON ELECTRICAL STORMS IN PATIENTS WITH CARDIOMIOPATHIES Open
Background Cardiac Sympathetic Denervation (CSD) has been recently proposed for the treatment of refractory ventricular arrhythmias (VAs) in patients with cardiomyopathy (CMP). A multicentric American and Indian case series suggested a gre…
View article: Relevance of comorbidities on initial combination therapy in pulmonary arterial hypertension
Relevance of comorbidities on initial combination therapy in pulmonary arterial hypertension Open
Rationale Demographic characteristics of pulmonary arterial hypertension (PAH) patients have changed over time, but the effects of cardiovascular risk factors on risk status and pulmonary vascular resistance (PVR) reduction with initial or…
View article: Clinicopathologic features and biologic behavior of canine splenic nodules with stromal, histiocytic and lymphoid components
Clinicopathologic features and biologic behavior of canine splenic nodules with stromal, histiocytic and lymphoid components Open
The term fibrohistiocytic nodule has been discouraged in favor of specific pathologic entities, including complex nodular hyperplasia, splenic stromal sarcoma and histiocytic sarcoma. Nevertheless, the diagnosis of splenic lesions with mix…
View article: When you hear hoofbeats, think zebras – pulmonary veno‐occlusive disease: A case report
When you hear hoofbeats, think zebras – pulmonary veno‐occlusive disease: A case report Open
Pulmonary veno‐occlusive disease (PVOD) is a rare disease. It may be idiopathic or associated, in particular, with connective tissue disease, or it may develop after radiation exposure; in heritable forms of PVOD, the inheritance is autoso…
View article: The paradox of pulmonary arterial hypertension in Italy in the COVID-19 era: is risk of disease progression around the corner?
The paradox of pulmonary arterial hypertension in Italy in the COVID-19 era: is risk of disease progression around the corner? Open
Objective The coronavirus disease 2019 (COVID-19) outbreak has led to significant restrictions on routine medical care. We conducted a multicentre nationwide survey of patients with pulmonary arterial hypertension (PAH) to determine the co…
View article: Quality control on digital cancer registration
Quality control on digital cancer registration Open
Study population: a random sample of 1,801 cases were extracted from 20,485 cases defined by digital procedures (DP). Each case was randomly assigned to two registrars (blinded to the DP outcome), who assessed it independently. The registr…
View article: Quality control on digital cancer registration
Quality control on digital cancer registration Open
Study population: a random sample of 1,801 cases were extracted from 20,485 cases defined by digital procedures (DP). Each case was randomly assigned to two registrars (blinded to the DP outcome), who assessed it independently. The registr…
View article: Prenatal Diagnosis of Clubfoot: Where Are We Now? Systematic Review and Meta-Analysis
Prenatal Diagnosis of Clubfoot: Where Are We Now? Systematic Review and Meta-Analysis Open
The primary methods for prenatal diagnosis of Clubfoot are ultrasound (US) and magnetic resonance imaging (MRI). An ultrasound is performed between the 1st trimester and the 28th week of pregnancy and it is reported to be used as a diagnos…
View article: Early Detection of Cardiotoxicity From Systemic and Radiation Therapy in Patients With Breast Cancer: Protocol for a Multi-Institutional Prospective Study
Early Detection of Cardiotoxicity From Systemic and Radiation Therapy in Patients With Breast Cancer: Protocol for a Multi-Institutional Prospective Study Open
Background The incidence of breast cancer is rising worldwide. Recent advances in systemic and local treatments have significantly improved survival rates of patients having early breast cancer. In the last decade, great attention has been…
View article: Acute pericarditis, Graves’ disease, and thymic hyperplasia: a case report
Acute pericarditis, Graves’ disease, and thymic hyperplasia: a case report Open
Background Acute pericarditis as a sign of mediastinal mass is rare and aetiological diagnosis can be challenging without adequate imaging. Case summary An 18-year-old woman came to our attention describing acute sharp chest pain radiated …
View article: Hadrontherapy for intra- or para-cardiac tumors: evaluation of cardiac radiation dose distribution and acute cardiac effects
Hadrontherapy for intra- or para-cardiac tumors: evaluation of cardiac radiation dose distribution and acute cardiac effects Open
Background There is growing interest in the possibility of using X-rays and hadrons (protons and carbon ions) for antiarrhythmic purposes both at the ventricular and the atrial level, but knowledge about the effects on cardiac tissue outsi…
View article: Long-term outcome of patients with cardiolaminopathy undergoing defibrillator implantation: single-center experience
Long-term outcome of patients with cardiolaminopathy undergoing defibrillator implantation: single-center experience Open
Background Mutations in the LMNA gene are associated with a high arrhythmic risk. The history of the disease in patients undergoing ICD implantation is poorly characterized. Purpose To evaluate the phenotype of patients with cardiolaminopa…