Alessandra Morano
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View article: Associations between adverse childhood experiences and vascular indicators of atherosclerosis measured in childhood and early to mid-adulthood: A systematic review
Associations between adverse childhood experiences and vascular indicators of atherosclerosis measured in childhood and early to mid-adulthood: A systematic review Open
Findings support associations between adverse childhood experiences and subclinical atherosclerotic progression, but evidence lacks quantity and quality. Prospective evidence identifying vascular changes associated with adverse childhood e…
View article: Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro
Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro Open
Objective Autoimmune encephalitis (AE) is characterized by inflammatory processes in the central nervous system and frequently presents with seizures. Even though an ictogenic potential has been shown for some antibodies against neuronal s…
View article: Transcriptomic and electrophysiological alterations underlying phenotypic variability in SCN1A-associated febrile seizures
Transcriptomic and electrophysiological alterations underlying phenotypic variability in SCN1A-associated febrile seizures Open
Febrile seizures (FS) are a common childhood neurological condition triggered by fever in children without prior neurological disorders. While generally benign, some individuals, particularly those with complex FS or genetic predisposition…
View article: Adjunctive Brivaracetam in People with Epilepsy and Intellectual Disability: Evidence from the BRIVAracetam Add-On First Italian netwoRk Study
Adjunctive Brivaracetam in People with Epilepsy and Intellectual Disability: Evidence from the BRIVAracetam Add-On First Italian netwoRk Study Open
View article: Second-Line Medications for Women Aged 10 to 50 Years With Idiopathic Generalized Epilepsy
Second-Line Medications for Women Aged 10 to 50 Years With Idiopathic Generalized Epilepsy Open
Importance Women with idiopathic generalized epilepsy (IGE) face challenges in treatment due to limited options that are both effective and safe. Objective To evaluate the effectiveness and safety of substitution monotherapy vs add-on ther…
View article: EEG microstates during resting-state and dissociative events in patients with psychogenic non-epileptic seizures
EEG microstates during resting-state and dissociative events in patients with psychogenic non-epileptic seizures Open
These findings provide insights into neurophysiological changes occurring during PNES, suggestingan interplay between pathological and adaptive mechanisms in their pathophysiology.
View article: Exploring the Effectiveness of Adjunctive Cenobamate in Focal Epilepsy: A Time-Based Analysis
Exploring the Effectiveness of Adjunctive Cenobamate in Focal Epilepsy: A Time-Based Analysis Open
View article: Long‐term outcomes and adaptive behavior in adult patients with Lennox–Gastaut syndrome
Long‐term outcomes and adaptive behavior in adult patients with Lennox–Gastaut syndrome Open
Objective Lennox–Gastaut syndrome (LGS) is a severe form of epilepsy characterized by difficult‐to‐control seizures and cognitive dysfunction. Previous studies mainly focused on pediatric populations, and little is known about the long‐ter…
View article: Perampanel in post-stroke epilepsy: Clinical practice data from the PERampanel as Only Concomitant antiseizure medication (PEROC) study
Perampanel in post-stroke epilepsy: Clinical practice data from the PERampanel as Only Concomitant antiseizure medication (PEROC) study Open
View article: Effectiveness and Safety of Adjunctive Cenobamate in People with Focal-Onset Epilepsy: Evidence from the First Interim Analysis of the BLESS Study
Effectiveness and Safety of Adjunctive Cenobamate in People with Focal-Onset Epilepsy: Evidence from the First Interim Analysis of the BLESS Study Open
View article: Membranes and Synaptosomes Used to Investigate Synaptic GABAergic Currents in Epileptic Patients
Membranes and Synaptosomes Used to Investigate Synaptic GABAergic Currents in Epileptic Patients Open
Among the most prevalent neurological disorders, epilepsy affects about 1% of the population worldwide. We previously found, using human epileptic tissues, that GABAergic neurotransmission impairment is a key mechanism that drives the path…
View article: Resting-state electroencephalography microstates as a marker of photosensitivity in juvenile myoclonic epilepsy
Resting-state electroencephalography microstates as a marker of photosensitivity in juvenile myoclonic epilepsy Open
Juvenile myoclonic epilepsy is an idiopathic generalized epilepsy syndrome associated with photosensitivity in approximately 30–40% of cases. Microstates consist of a brief period of time during which the topography of the whole resting-st…
View article: Perampanel as only add-on epilepsy treatment in elderly: A subgroup analysis of real-world data from retrospective, multicenter, observational study
Perampanel as only add-on epilepsy treatment in elderly: A subgroup analysis of real-world data from retrospective, multicenter, observational study Open
View article: Epilepsy with generalized tonic–clonic seizures alone: Electroclinical features and prognostic patterns
Epilepsy with generalized tonic–clonic seizures alone: Electroclinical features and prognostic patterns Open
Objective Epilepsy with generalized tonic–clonic seizures alone (GTCA) is a common but poorly characterized idiopathic generalized epilepsy (IGE) syndrome. Hence, we investigated electroclinical features, seizure outcome, and antiseizure m…
View article: Levetiracetam vs Lamotrigine as First-Line Antiseizure Medication in Female Patients With Idiopathic Generalized Epilepsy
Levetiracetam vs Lamotrigine as First-Line Antiseizure Medication in Female Patients With Idiopathic Generalized Epilepsy Open
Importance After the recent limitations to prescribing valproate, many studies have highlighted the challenging management of female patients of reproductive age with idiopathic generalized epilepsy (IGE). However, no study, to the authors…
View article: Plasma Biomarker Profile and Clinical Correlations in Adult Patients With Tuberous Sclerosis Complex
Plasma Biomarker Profile and Clinical Correlations in Adult Patients With Tuberous Sclerosis Complex Open
Our exploratory study documented a significant increase of GFAP plasma concentration in adult patients with TSC, correlated with their neurologic severity, supporting the central role of astrocytopathy in TSC pathophysiology.
View article: Adjunctive brivaracetam and sustained seizure frequency reduction in very active focal epilepsy
Adjunctive brivaracetam and sustained seizure frequency reduction in very active focal epilepsy Open
Objective This study aimed to explore the effectiveness of brivaracetam (BRV) according to baseline seizure frequency and past treatment history in subjects with focal epilepsy who were included in the Brivaracetam Add‐On First Italian Net…
View article: Musicogenic epilepsy in paraneoplastic limbic encephalitis: a video‐EEG case report
Musicogenic epilepsy in paraneoplastic limbic encephalitis: a video‐EEG case report Open
Musicogenic epilepsy (ME), a peculiar form of reflex epilepsy, represents a neurological rarity and yet another demonstration of the extraordinary power of music on the human brain. Despite the heterogeneity of the reported musical trigger…
View article: Sex‐based electroclinical differences and prognostic factors in epilepsy with eyelid myoclonia
Sex‐based electroclinical differences and prognostic factors in epilepsy with eyelid myoclonia Open
Although a striking female preponderance has been consistently reported in epilepsy with eyelid myoclonia (EEM), no study has specifically explored the variability of clinical presentation according to sex in this syndrome. Here, we aimed …
View article: Anti-LGI1 encephalitis: A family affair
Anti-LGI1 encephalitis: A family affair Open
View article: Progressive myoclonus epilepsies due to <i>SEMA6B</i> mutations. New variants and appraisal of published phenotypes
Progressive myoclonus epilepsies due to <i>SEMA6B</i> mutations. New variants and appraisal of published phenotypes Open
Variants of SEMA6B have been identified in an increasing number of patients, often presenting with progressive myoclonus epilepsy (PME), and to lesser extent developmental encephalopathy, with or without epilepsy. The exon 17 is mainly inv…
View article: GABAergic Neurotransmission in Human Tissues Is Modulated by Cannabidiol
GABAergic Neurotransmission in Human Tissues Is Modulated by Cannabidiol Open
Recently, the potential use of phytocannabinoids (pCBs) to treat different pathological conditions has attracted great attention in the scientific community. Among the different pCBs, cannabidiol (CBD) has showed interesting biological pro…
View article: Structural Cerebellar Abnormalities and Parkinsonism in Patients with 22q11.2 Deletion Syndrome
Structural Cerebellar Abnormalities and Parkinsonism in Patients with 22q11.2 Deletion Syndrome Open
Background: The phenotypic expression of 22q11.2 deletion syndrome (22q11.2DS) is variable and may include cognitive, psychiatric, and neurological manifestations, e.g., parkinsonism. We investigated brain structural alterations in patient…
View article: Spectrum of epilepsy with eyelid myoclonia: Delineation of disease subtypes from a large multicenter study
Spectrum of epilepsy with eyelid myoclonia: Delineation of disease subtypes from a large multicenter study Open
Objective Epilepsy with eyelid myoclonia (EEM) has been associated with marked clinical heterogeneity. Early epilepsy onset has been recently linked to lower chances of achieving sustained remission and to a less favorable neuropsychiatric…
View article: GABAA receptor function is enhanced by Interleukin-10 in human epileptogenic gangliogliomas and its effect is counteracted by Interleukin-1β
GABAA receptor function is enhanced by Interleukin-10 in human epileptogenic gangliogliomas and its effect is counteracted by Interleukin-1β Open
View article: EEG Markers of Treatment Resistance in Idiopathic Generalized Epilepsy: From Standard EEG Findings to Advanced Signal Analysis
EEG Markers of Treatment Resistance in Idiopathic Generalized Epilepsy: From Standard EEG Findings to Advanced Signal Analysis Open
Idiopathic generalized epilepsy (IGE) represents a common form of epilepsy in both adult and pediatric epilepsy units. Although IGE has been long considered a relatively benign epilepsy syndrome, a remarkable proportion of patients could b…
View article: Brivaracetam as Early Add-On Treatment in Patients with Focal Seizures: A Retrospective, Multicenter, Real-World Study
Brivaracetam as Early Add-On Treatment in Patients with Focal Seizures: A Retrospective, Multicenter, Real-World Study Open
View article: Effectiveness of perampanel as the only add‐on: Retrospective, multicenter, observational real‐life study on epilepsy patients
Effectiveness of perampanel as the only add‐on: Retrospective, multicenter, observational real‐life study on epilepsy patients Open
Objective Perampanel (PER) is indicated as adjunctive antiseizure medication (ASM) in adolescents and adults with epilepsy. Data from clinical trials show good efficacy and tolerability, while limited information is available on the routin…
View article: Late-onset seizures and epilepsy: Electroclinical features suggestive of autoimmune etiology
Late-onset seizures and epilepsy: Electroclinical features suggestive of autoimmune etiology Open
Introduction Late-onset epilepsy (LOE) has recently become a topic of intense research. Besides stroke, tumors, and dementia, autoimmune encephalitis (AE) has emerged as another possible cause of recurrent seizures in the elderly, and may …
View article: An Italian consensus on the management of Lennox-Gastaut syndrome
An Italian consensus on the management of Lennox-Gastaut syndrome Open