Alessandra Pierangeli
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View article: Pattern Recognition Receptors (PRRs) Expression and Activation in COVID-19 and Long COVID: From SARS-CoV-2 Escape Mechanisms to Emerging PRR-Targeted Immunotherapies
Pattern Recognition Receptors (PRRs) Expression and Activation in COVID-19 and Long COVID: From SARS-CoV-2 Escape Mechanisms to Emerging PRR-Targeted Immunotherapies Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is recognized by pattern recognition receptors (PRRs), which play a vital role in triggering innate immune responses such as the production of type I and III interferons (IFNs). …
View article: Pattern Recognition Receptors Expression and Activation in COVID-19 and Long COVID: From SARS-CoV-2 Escape Mechanisms to Emerging Immunotherapies
Pattern Recognition Receptors Expression and Activation in COVID-19 and Long COVID: From SARS-CoV-2 Escape Mechanisms to Emerging Immunotherapies Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is recognized by pattern recognition receptors (PRRs), which play a vital role in triggering innate immune responses such as the production of type I and III interferons (IFNs). …
View article: Multicenter Cross-sectional Study on the Epidemiology of Human Metapneumovirus in Italy, 2022–2024, With a Focus on Adults Over 50 Years of Age
Multicenter Cross-sectional Study on the Epidemiology of Human Metapneumovirus in Italy, 2022–2024, With a Focus on Adults Over 50 Years of Age Open
Background Human metapneumovirus (hMPV) infections have a significant impact on public health. However, the extent of this burden in Italy remains poorly defined due to a lack of comprehensive data. The aim of this cross-sectional multicen…
View article: Elexacaftor/tezacaftor/ivacaftor (ETI) therapy modifies the expression of interferon beta and inflammatory genes in the airways of adult patients with cystic fibrosis: a pilot study
Elexacaftor/tezacaftor/ivacaftor (ETI) therapy modifies the expression of interferon beta and inflammatory genes in the airways of adult patients with cystic fibrosis: a pilot study Open
Cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies have revolutionized the treatment of cystic fibrosis (CF) by targeting the underlying protein defect. Investigating how elexacaftor/tezacaftor/ivacaftor (ETI) t…
View article: The added value of diagnostics to characterize age-specific patterns of respiratory viral infections and coinfections and to detect emerging threats
The added value of diagnostics to characterize age-specific patterns of respiratory viral infections and coinfections and to detect emerging threats Open
Respiratory viruses can cause age-specific seasonal peaks that are modulated by viral interference phenomena. Molecular diagnostic data should be integrated with surveillance programs to characterize seasonal circulation patterns of common…
View article: NRF2 Antioxidant Response and Interferon‐Stimulated Genes Are Differentially Expressed in SARS‐CoV‐2‐Positive Young Subjects
NRF2 Antioxidant Response and Interferon‐Stimulated Genes Are Differentially Expressed in SARS‐CoV‐2‐Positive Young Subjects Open
Background Several respiratory viruses, including Severe Acute Respiratory Syndrome‐Coronavirus‐2 (SARS‐CoV‐2), suppress nuclear factor‐E2‐related factor‐2 (NRF2) antioxidant response, generating oxidative stress conditions to its advantag…
View article: High rates of anal Merkel Cell Polyomavirus and HPV co‐infection among people living with HIV
High rates of anal Merkel Cell Polyomavirus and HPV co‐infection among people living with HIV Open
Knowledge of Human Polyomavirus (HPyV) infection in the anal area and its association with sexually transmitted infections such as Human Papillomavirus (HPV) and Human Immunodeficiency Virus (HIV) remains limited. Therefore, anal specimens…
View article: An Update on the Entomology, Virology, Pathogenesis, and Epidemiology Status of West Nile and Dengue Viruses in Europe (2018–2023)
An Update on the Entomology, Virology, Pathogenesis, and Epidemiology Status of West Nile and Dengue Viruses in Europe (2018–2023) Open
In recent decades, increases in temperature and tropical rainfall have facilitated the spread of mosquito species into temperate zones. Mosquitoes are vectors for many viruses, including West Nile virus (WNV) and dengue virus (DENV), and p…
View article: TTV and CMV viral load dynamics: Which emerges first during immunosuppression?
TTV and CMV viral load dynamics: Which emerges first during immunosuppression? Open
Novel biomarkers reflecting the degree of immunosuppression in transplant patients are required to ensure eventual personalized equilibrium between rejection and infection risks. With the above aim, Torque Teno Virus (TTV) viremia was prec…
View article: Sequence analysis of respiratory syncytial virus cases reveals a novel subgroup -B strain circulating in north-central Italy after pandemic restrictions
Sequence analysis of respiratory syncytial virus cases reveals a novel subgroup -B strain circulating in north-central Italy after pandemic restrictions Open
This study describes the temporal dynamics of post-pandemic RSV subgroups and uncovers a lineage of RSV-B with high genetic divergence that may have increased the impact of decreased population immunity.
View article: SARS-CoV-2–specific mucosal immune response in vaccinated versus infected children
SARS-CoV-2–specific mucosal immune response in vaccinated versus infected children Open
The anti-COVID-19 intramuscular vaccination induces a strong systemic but a weak mucosal immune response in adults. Little is known about the mucosal immune response in children infected or vaccinated against SARS-CoV-2. We found that 28% …
View article: The Epidemiology of Anal Human Papillomavirus (HPV) in HIV-Positive and HIV-Negative Women and Men: A Ten-Year Retrospective Observational Study in Rome (Italy)
The Epidemiology of Anal Human Papillomavirus (HPV) in HIV-Positive and HIV-Negative Women and Men: A Ten-Year Retrospective Observational Study in Rome (Italy) Open
Human papillomaviruses (HPVs) commonly infect the anogenital mucosa; most infections are transient, but a fraction of those caused by high-risk (HR) types persist and may lead to anogenital cancer. The epidemiology of HPV genotypes in anal…
View article: Detection of human papillomavirus infection in oral mucosal diseases
Detection of human papillomavirus infection in oral mucosal diseases Open
Background:
\nHuman papillomavirus (HPV) infection accounts for more than 70% of oropharyngeal
\ncancers, but only a small proportion of oral potentially malignant disorders and oral
\nsquamous cell carcinoma. The aim of our study was to i…
View article: An overview on viral interference during SARS-CoV-2 pandemic
An overview on viral interference during SARS-CoV-2 pandemic Open
Respiratory viruses represent the most frequent cause of mortality, morbidity and high healthcare costs for emergency visits and hospitalization in the pediatric age. Respiratory viruses can circulate simultaneously and can potentially inf…
View article: Interferon system I e III protects patients with cystic fibrosis from Sars Cov2 infection
Interferon system I e III protects patients with cystic fibrosis from Sars Cov2 infection Open
Interferon system I e III protects patients with cystic fibrosis from SARS-CoV2 infection
View article: Detection of Human Papillomavirus infection in oral mucosal diseases: a single-center study
Detection of Human Papillomavirus infection in oral mucosal diseases: a single-center study Open
Background: Human papillomavirus (HPV) infection accounts for more than 70% of oropharyngeal cancers, but only a small proportion of oral potentially malignant disorders and oral squamous cell carcinoma. The aim of our study was to investi…
View article: NRF2 Antioxidant Response and Interferon-Stimulated Genes Are Differentially Expressed in Respiratory-Syncytial-Virus- and Rhinovirus-Infected Hospitalized Children
NRF2 Antioxidant Response and Interferon-Stimulated Genes Are Differentially Expressed in Respiratory-Syncytial-Virus- and Rhinovirus-Infected Hospitalized Children Open
Respiratory diseases caused by respiratory syncytial virus (RSV) and human rhinovirus (HRV) are frequent causes of the hospitalization of children; nonetheless, RSV is responsible for the most severe and life-threatening illnesses. Viral i…
View article: Alterations in the Expression of IFN Lambda, IFN Gamma and Toll-like Receptors in Severe COVID-19 Patients
Alterations in the Expression of IFN Lambda, IFN Gamma and Toll-like Receptors in Severe COVID-19 Patients Open
Contradictory results have been reported regarding interferon (IFN) lambda (λ1–3) and IFN gamma (γ) production in COVID-19 patients. To gain insight into the roles played by these IFNs in SARS-CoV-2 infection, IFNλ1–3 and IFNγ mRNA express…
View article: Natural Flavonoid Derivatives Have Pan-Coronavirus Antiviral Activity
Natural Flavonoid Derivatives Have Pan-Coronavirus Antiviral Activity Open
The SARS-CoV-2 protease (3CLpro) is one of the key targets for the development of efficacious drugs for COVID-19 treatment due to its essential role in the life cycle of the virus and exhibits high conservation among coronaviruses. Recent …
View article: Common Microbial Genital Infections and Their Impact on the Innate Immune Response to HPV in Cervical Cells
Common Microbial Genital Infections and Their Impact on the Innate Immune Response to HPV in Cervical Cells Open
The persistence of high-risk (HR) human papillomavirus (HPV) genotypes is a prerequisite of cervical cancer. It is not clear whether and how bacterial vaginosis (BV) and sexually transmitted infections (STIs) cause higher rates of persiste…
View article: An Italian Multicenter Study on the Epidemiology of Respiratory Syncytial Virus During SARS-CoV-2 Pandemic in Hospitalized Children
An Italian Multicenter Study on the Epidemiology of Respiratory Syncytial Virus During SARS-CoV-2 Pandemic in Hospitalized Children Open
Since the beginning of 2020, a remarkably low incidence of respiratory virus hospitalizations has been reported worldwide. We prospectively evaluated 587 children, aged <12 years, admitted for respiratory tract infections from 1 Septemb…
View article: Comparison by Age of the Local Interferon Response to SARS-CoV-2 Suggests a Role for IFN-ε and -ω
Comparison by Age of the Local Interferon Response to SARS-CoV-2 Suggests a Role for IFN-ε and -ω Open
Children generally develop a mild disease after SARS-CoV-2 infection whereas older adults are at risk of developing severe COVID-19. Recent transcriptomic analysis showed pre-activated innate immunity in children, resulting in a more effec…