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View article: Continous or fixedcarfilzomib, lenalidomide and dexamethasone (krd) for relapsed-refractory multiple myeloma: long-term follow-up from a multicenter, retrospective real-life surveyfrom European myeloma network (emn) Italy
Continous or fixedcarfilzomib, lenalidomide and dexamethasone (krd) for relapsed-refractory multiple myeloma: long-term follow-up from a multicenter, retrospective real-life surveyfrom European myeloma network (emn) Italy Open
View article: Towards a disease digital twin: Howard T. Odum's legacy for cancer biology and medicine
Towards a disease digital twin: Howard T. Odum's legacy for cancer biology and medicine Open
View article: Classic Hairy Cell Leukemia With <scp>MAP2K1</scp> Mutation: Diagnosis and Targeted Therapy
Classic Hairy Cell Leukemia With <span>MAP2K1</span> Mutation: Diagnosis and Targeted Therapy Open
View article: Promoting Sustainable Career Development in Inclusive Education: A Psychometric Study of Career Maturity Among Students with Special Educational Needs
Promoting Sustainable Career Development in Inclusive Education: A Psychometric Study of Career Maturity Among Students with Special Educational Needs Open
Despite progress in inclusive education, students with Special Educational Needs (SEN) often lack valid, tailored tools for career assessment, limiting equitable transitions to adulthood and employment. Closing this gap is crucial for Sust…
View article: COVID-19 Vaccine Experience: Loss of Humoral Response Following Autologous Stem Cell Transplantation in Multiple Myeloma Patients and Positive Effect of Booster Dose
COVID-19 Vaccine Experience: Loss of Humoral Response Following Autologous Stem Cell Transplantation in Multiple Myeloma Patients and Positive Effect of Booster Dose Open
Background/Objectives: This prospective study investigated the impact of high-dose chemotherapy and autologous stem cell transplantation (ASCT) on anti-COVID-19 antibody levels in previously vaccinated multiple myeloma (MM) patients with c…
View article: 220 | HIGH EFFICACY OF BRIEF BRAF AND MEK COINHIBITION, ALONE AND COMBINED WITH ANTI‐CD20 IMMUNOTHERAPY, IN RELAPSED/REFRACTORY HAIRY CELL LEUKEMIA: A PHASE‐2 TRIAL
220 | HIGH EFFICACY OF BRIEF BRAF AND MEK COINHIBITION, ALONE AND COMBINED WITH ANTI‐CD20 IMMUNOTHERAPY, IN RELAPSED/REFRACTORY HAIRY CELL LEUKEMIA: A PHASE‐2 TRIAL Open
View article: Supplementary Figure S1 from Targeting Acetyl-CoA Carboxylase Suppresses <i>De Novo</i> Lipogenesis and Tumor Cell Growth in Multiple Myeloma
Supplementary Figure S1 from Targeting Acetyl-CoA Carboxylase Suppresses <i>De Novo</i> Lipogenesis and Tumor Cell Growth in Multiple Myeloma Open
Supplementary Figure S1. Expression profiling and correlation analysis of MYC and ACC1 in patients with newly diagnosed multiple myeloma (NDMM).
View article: Supplementary Figure S5 from Targeting Acetyl-CoA Carboxylase Suppresses <i>De Novo</i> Lipogenesis and Tumor Cell Growth in Multiple Myeloma
Supplementary Figure S5 from Targeting Acetyl-CoA Carboxylase Suppresses <i>De Novo</i> Lipogenesis and Tumor Cell Growth in Multiple Myeloma Open
Supplementary Figure S5. Gene set enrichment analysis in MM cells following ND-646 treatment, and evaluation of cell growth under combined treatment with ND-646 and simvastatin.
View article: Data from Targeting Acetyl-CoA Carboxylase Suppresses <i>De Novo</i> Lipogenesis and Tumor Cell Growth in Multiple Myeloma
Data from Targeting Acetyl-CoA Carboxylase Suppresses <i>De Novo</i> Lipogenesis and Tumor Cell Growth in Multiple Myeloma Open
Purpose:In multiple myeloma, tumor cells reprogram metabolic pathways to sustain growth and monoclonal immunoglobulin production. This study examines acetyl-CoA carboxylase 1 (ACC1), the enzyme driving the rate-limiting step in d…
View article: Supplementary Figure S2 from Targeting Acetyl-CoA Carboxylase Suppresses <i>De Novo</i> Lipogenesis and Tumor Cell Growth in Multiple Myeloma
Supplementary Figure S2 from Targeting Acetyl-CoA Carboxylase Suppresses <i>De Novo</i> Lipogenesis and Tumor Cell Growth in Multiple Myeloma Open
Supplementary Figure S2. Quantitative analysis of ACACA expression in multiple myeloma (MM) cell lines.
View article: Supplementary Figure S4 from Targeting Acetyl-CoA Carboxylase Suppresses <i>De Novo</i> Lipogenesis and Tumor Cell Growth in Multiple Myeloma
Supplementary Figure S4 from Targeting Acetyl-CoA Carboxylase Suppresses <i>De Novo</i> Lipogenesis and Tumor Cell Growth in Multiple Myeloma Open
Supplementary Figure S4. Impact of pharmacological inhibition (ND-630 and ND-646) and ACC1 knockdown on MM cell viability, proliferation, and de novo lipogenesis (DNL) rates in MYC overexpressed MM cells.
View article: Supplementary Figure S3 from Targeting Acetyl-CoA Carboxylase Suppresses <i>De Novo</i> Lipogenesis and Tumor Cell Growth in Multiple Myeloma
Supplementary Figure S3 from Targeting Acetyl-CoA Carboxylase Suppresses <i>De Novo</i> Lipogenesis and Tumor Cell Growth in Multiple Myeloma Open
Supplementary Figure S3. Representative western blot analysis showing protein levels of ACC1, phosphorylated ACC (pACC), and MYC in MM cells.
View article: Ultrasound biomicroscopy assessment of the subclinical involvement of the aqueous drainage structures after silicone oil tamponade
Ultrasound biomicroscopy assessment of the subclinical involvement of the aqueous drainage structures after silicone oil tamponade Open
View article: BNT162b2 mRNA vaccination affects the gut microbiome composition of patients with follicular lymphoma and chronic lymphocytic leukemia
BNT162b2 mRNA vaccination affects the gut microbiome composition of patients with follicular lymphoma and chronic lymphocytic leukemia Open
View article: Immune Response and Breakthrough Infection Risk After SARS-CoV-2 Vaccines in Patients with Hemoglobinopathy: A Single Center Experience
Immune Response and Breakthrough Infection Risk After SARS-CoV-2 Vaccines in Patients with Hemoglobinopathy: A Single Center Experience Open
Background: Immune system impairment is frequently reported in patients affected by hemoglobinopathies due to various mechanisms, including iron accumulation, antigenic stimulation due to numerous transfusions, chronic hemolysis, and a gen…
View article: Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis
Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis Open
In conclusion, our results unveil lactate as a key regulator of immune escape and BM fibrotic transformation in MF patients, suggesting MCT1 blocking as a novel antifibrotic strategy.
View article: Respiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023–2024: <scp>EPICOVIDEHA</scp>‐<scp>EPIFLUEHA</scp> Report
Respiratory Viruses in Patients With Hematological Malignancy in Boreal Autumn/Winter 2023–2024: <span>EPICOVIDEHA</span>‐<span>EPIFLUEHA</span> Report Open
Community‐acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large‐scale, real‐world data on CARV in these patients is limited.…
View article: Ultrasound biomicroscopy assessment of the subclinical involvement of the aqueous drainage structures after silicone oil tamponade
Ultrasound biomicroscopy assessment of the subclinical involvement of the aqueous drainage structures after silicone oil tamponade Open
Purpose: To examine the subclinical ultrasound biomicroscopy (UBM) changes in the anterior segment (AS) of eyes after silicone oil tamponade (SOT) permanence. Methods: This observational study enrolled patients undergone pars plana vitrect…
View article: Donne, disabilità e violenza. Sfide educative per la formazione e la ricerca nella prospettiva intersezionale
Donne, disabilità e violenza. Sfide educative per la formazione e la ricerca nella prospettiva intersezionale Open
L'articolo approfondisce le condizioni multidiscriminatorie a cui sono esposte le donne con disabilità, a partire dall'adozione di una prospettiva critica intersezionale (Crenshaw, 1989; 2017). I primi paragrafi esaminano lo scenari…
View article: Correction: Russo et al. The Role of Dielectrophoresis for Cancer Diagnosis and Prognosis. Cancers 2022, 14, 198
Correction: Russo et al. The Role of Dielectrophoresis for Cancer Diagnosis and Prognosis. Cancers 2022, 14, 198 Open
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View article: IgG-k/IgG-λ Para-Osseous Plasmacytoma Relapsed as Soft-Tissue Plasmacytoma with IgA-k Immunophenotype: A Case Report and Review of the Literature on Related Biochemical Aspects
IgG-k/IgG-λ Para-Osseous Plasmacytoma Relapsed as Soft-Tissue Plasmacytoma with IgA-k Immunophenotype: A Case Report and Review of the Literature on Related Biochemical Aspects Open
Neoplastic plasma cells (PCs) proliferation at anatomic sites dislocated from the bone marrow (BM) or their contiguous growth from osseous lesions that disrupt the cortical bone is termed extramedullary multiple myeloma (EMD). EMD still re…
View article: Unveiling and challenging the identity, formation, and evolution of Transformation Theory
Unveiling and challenging the identity, formation, and evolution of Transformation Theory Open
In this contribution, we explore established and emerging facets that contribute to shaping the theoretical landscape of transformation theory. Throughout our discussion, we contemplate the multifaceted nature of transformative learning, a…
View article: Enhanced Antitumor Activity by the Combination of Dasatinib and Selinexor in Chronic Myeloid Leukemia
Enhanced Antitumor Activity by the Combination of Dasatinib and Selinexor in Chronic Myeloid Leukemia Open
Background: Chronic myeloid leukemia is a hematological malignancy characterized by the abnormal proliferation of leukemic cells. Despite significant progress with tyrosine kinase inhibitors, such as Dasatinib, resistance remains a challen…
View article: Psychological distress and suicidal ideation in Sicilian Medical Students: The SMS-ME project
Psychological distress and suicidal ideation in Sicilian Medical Students: The SMS-ME project Open
Background: Medical students are at high risk for mental disorders, and the COVID-19 pandemic might have exacerbated psychological distress. However, no data are available for the southern part of Italy. The SMS-ME (Sicilian Medical Studen…
View article: Comprehensive analysis of clinical outcomes, infectious complications and microbiological data in newly diagnosed multiple myeloma patients: a retrospective observational study of 92 subjects
Comprehensive analysis of clinical outcomes, infectious complications and microbiological data in newly diagnosed multiple myeloma patients: a retrospective observational study of 92 subjects Open
View article: Effectiveness, safety, and tolerability of delayed dexamethasone, rituximab, and cyclophosphamide as first-line treatment in patients with Waldenström macroglobulinemia: data from the Sicilian Myeloma Network
Effectiveness, safety, and tolerability of delayed dexamethasone, rituximab, and cyclophosphamide as first-line treatment in patients with Waldenström macroglobulinemia: data from the Sicilian Myeloma Network Open
Background Waldenström macroglobulinemia (WM) is a rare and indolent B-cell lymphoproliferative disorder with greater incidence in elderly patients where a precise algorithm of initial therapy is still not clear. Immunochemotherapy regimen…
View article: Dexamethasone treatment for COVID-19 is related to increased mortality in hematologic malignancy patients: results from the EPICOVIDEHA Registry
Dexamethasone treatment for COVID-19 is related to increased mortality in hematologic malignancy patients: results from the EPICOVIDEHA Registry Open
The optimal treatment strategies for hematological malignancy patients with COVID19 are still unclear with respect to the selection and timing of anti-viral as well as anti-inflammatory therapies. Most COVID-19 management recommendations h…
View article: Baseline IgM Amounts Can Identify Patients with Poor Outcomes: Results from a Real-Life Single-Center Study on Classical Hodgkin Lymphoma
Baseline IgM Amounts Can Identify Patients with Poor Outcomes: Results from a Real-Life Single-Center Study on Classical Hodgkin Lymphoma Open
Hodgkin Lymphoma (HL) is characterized by an inflammatory background in which the reactive myeloid cells may exert an immune-suppressive effect related to the progression of the disease. Immunoglobulin M is the first antibody isotype produ…
View article: Risk assessment of ANAS tunnel stock in the north-east of Italy and the case study of the SHM of Comelico tunnel
Risk assessment of ANAS tunnel stock in the north-east of Italy and the case study of the SHM of Comelico tunnel Open
View article: Risk assessment of ANAS bridge stock in the north-east of Italy
Risk assessment of ANAS bridge stock in the north-east of Italy Open