Alessandro Barbieri
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View article: A progranulin variant causing childhood interstitial lung disease responsive to anti-TNF-α biologic therapy
A progranulin variant causing childhood interstitial lung disease responsive to anti-TNF-α biologic therapy Open
This work was supported by a grant from the Chan Zuckerberg Initiative Patient-Partnered Collaboration for single-cell analysis of rare inflammatory pediatric disease, the Corkin Family Fund for Research, and in part by cooperative agreeme…
View article: Exploring the Utility of Circulating Endothelial Cell-Derived Extracellular Vesicles as Markers of Health and Damage of Vasal Endothelium in Systemic Sclerosis Patients Treated with Iloprost
Exploring the Utility of Circulating Endothelial Cell-Derived Extracellular Vesicles as Markers of Health and Damage of Vasal Endothelium in Systemic Sclerosis Patients Treated with Iloprost Open
Endothelial cell-derived extracellular vesicles (eEVs) are released from endothelial cells, signifying endothelial integrity. Systemic Sclerosis (SSc) is a rare disease causing skin and organ fibrosis with early vascular damage. Iloprost, …
View article: On the Use of Fractional-Order PID Controllers for TITO Processes
On the Use of Fractional-Order PID Controllers for TITO Processes Open
In this paper we investigate the performance that can be achieved by using Fractional-Order Proportional-Integral-Derivative (FOPID) controllers for Multiple-Input-Multiple-Output (MIMO) industrial processes. In particular, we consider sev…
View article: Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors
Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors Open
Antibody heavy chain (HC) and light chain (LC) variable region exons are assembled by V(D)J recombination. V(D)J junctional regions encode complementarity-determining-region 3 (CDR3), an antigen-contact region immensely diversified through…
View article: Profibrotic Effects of Endothelin-1 on Fibroblasts Are Mediated by Aldosterone In Vitro: Relevance to the Pathogenesis and Therapy of Systemic Sclerosis and Pulmonary Arterial Hypertension
Profibrotic Effects of Endothelin-1 on Fibroblasts Are Mediated by Aldosterone In Vitro: Relevance to the Pathogenesis and Therapy of Systemic Sclerosis and Pulmonary Arterial Hypertension Open
Endothelin-1 (ET-1) is a vasoactive and profibrotic peptide that plays a pivotal role in diseases such as systemic sclerosis (SSc) and pulmonary arterial hypertension (PAH), by inducing fibrosis and vascular remodeling. Such effects may be…
View article: Humanized V(D)J-rearranging and TdT-expressing Mouse Vaccine Models with Physiological HIV-1 Broadly Neutralizing Antibody Precursors
Humanized V(D)J-rearranging and TdT-expressing Mouse Vaccine Models with Physiological HIV-1 Broadly Neutralizing Antibody Precursors Open
Antibody heavy chain (HC) and light chain (LC) variable region exons are assembled by V(D)J recombination. V(D)J junctional regions encode complementarity-determining-region 3 (CDR3), an antigen-contact region immensely diversified through…
View article: Aging Predisposes B cells to Malignancy by Activating c-Myc and Perturbing the Genome and Epigenome
Aging Predisposes B cells to Malignancy by Activating c-Myc and Perturbing the Genome and Epigenome Open
Age is the single major risk factor for human cancer, but naturally occurring cancers are rarely studied in aging models. Like humans, mice spontaneously develop cancer with age, and standard laboratory strains are predisposed for B-cell l…
View article: Identification of a Novel Serological Marker in Seronegative Rheumatoid Arthritis Using the Peptide Library Approach
Identification of a Novel Serological Marker in Seronegative Rheumatoid Arthritis Using the Peptide Library Approach Open
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation mainly affecting the joints leading to cartilage and bone destruction. The definition of seropositive or seronegative RA is based on the prese…
View article: Integrating hydrological constraints for hydropower in energy models: the case of the Zambesi River Basin in the Southern African Power Pool
Integrating hydrological constraints for hydropower in energy models: the case of the Zambesi River Basin in the Southern African Power Pool Open
<p>Ensuring reliable supplies of energy and water are two important Sustainable Development Goals, particularly for Sub-Saharan African countries. The energy and water challenges are however not independent, and the interlinkages bet…
View article: Hypomorphic Rag1 mutations alter the preimmune repertoire at early stages of lymphoid development
Hypomorphic Rag1 mutations alter the preimmune repertoire at early stages of lymphoid development Open
Key Points Mice with hypomorphic mutations in the Rag1 C-terminal domain are a model of leaky combined immunodeficiency with autoantibodies. Hypomorphic C-terminal domain Rag1 mutations cause repertoire skewing at the earliest stages of B-…