Alessandro Crippa
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View article: Virtual Reality-Based Postural Balance Training in Autistic Children: A Pilot Randomized Controlled Trial
Virtual Reality-Based Postural Balance Training in Autistic Children: A Pilot Randomized Controlled Trial Open
Background/Objectives: Beyond the core characteristics of the condition, autistic individuals often significantly struggle with postural balance. This pilot study aimed to investigate the effects of an immersive virtual reality-based train…
View article: Internalizing and Externalizing Traits During Adolescence: Using Epigenetics and Perinatal Risks to Differentiate Clusters of Symptoms
Internalizing and Externalizing Traits During Adolescence: Using Epigenetics and Perinatal Risks to Differentiate Clusters of Symptoms Open
This cross-sectional study aims to identify clusters of internalizing and externalizing traits during adolescence using a bottom-up approach. The second aim is to investigate whether the different clusters differ by environmental risk fact…
View article: Clinical outcomes of a 12-week, first treatment with methylphenidate in an Italian representative sample of children and adolescents with ADHD
Clinical outcomes of a 12-week, first treatment with methylphenidate in an Italian representative sample of children and adolescents with ADHD Open
Current clinical guidelines suggest methylphenidate (MPH) as first-line option for treatment of attention-deficit/hyperactivity disorder (ADHD). However, the Lombardy ADHD Registry initiative has recently raised some concerns about discrep…
View article: Protein‐Altering Variants' Analysis in Autism Subgroups Uncovers Early Brain‐Expressed Gene Modules Relevant to Autism Pathophysiology
Protein‐Altering Variants' Analysis in Autism Subgroups Uncovers Early Brain‐Expressed Gene Modules Relevant to Autism Pathophysiology Open
Understanding the functional implications of genes' variants in autism heterogeneity is challenging. Gene set analysis examines the cumulative effect of multiple functionally converging genes. Here we explored whether a multi‐step analysis…
View article: Time-Normalization Approach for fNIRS Data During Tasks with High Variability in Duration
Time-Normalization Approach for fNIRS Data During Tasks with High Variability in Duration Open
Functional near-infrared spectroscopy (fNIRS) is particularly suitable for measuring brain activity during motor tasks, due to its portability and good motion tolerance. In such cases, the trials’ duration may vary depending on the experim…
View article: A systematic review and synthesis of 489 studies investigating treatments for negative symptoms in the schizophrenia spectrum: Trial designs, demographics and clinical characteristics
A systematic review and synthesis of 489 studies investigating treatments for negative symptoms in the schizophrenia spectrum: Trial designs, demographics and clinical characteristics Open
Negative symptoms in schizophrenia spectrum are associated with minimal treatment responses. The search for effective treatments is potentially hampered by heterogenous study-designs and sample characteristics depending on the intervention…
View article: Potentially damaging variants’ analysis in autism subgroups uncovers early brain-expressed gene modules relevant to autism pathophysiology
Potentially damaging variants’ analysis in autism subgroups uncovers early brain-expressed gene modules relevant to autism pathophysiology Open
Background Understanding the functional implications of genes’ variants related to autism heterogeneity represents a crucial challenge. Gene set analysis examines the combined effect of multiple genes with convergent biological functions. …
View article: Prospective Interrelation Between Sensory Sensitivity and Fine Motor Skills During the First 18 Months Predicts Later Autistic Features
Prospective Interrelation Between Sensory Sensitivity and Fine Motor Skills During the First 18 Months Predicts Later Autistic Features Open
Sensory features are included in the diagnostic criteria of autism and atypical sensory responsiveness may produce “cascading effects” on later development. Similarly, autistic individuals often struggle with motor coordination and early d…
View article: Decreased central corpus callosum volume is associated with repetitive behaviours and motor difficulties in autistic children
Decreased central corpus callosum volume is associated with repetitive behaviours and motor difficulties in autistic children Open
Along with the core characteristics of the condition, autistic individuals commonly experience motor coordination difficulties, potentially related to a reduced cortical connectivity. Being the largest human commissure, the corpus callosum…
View article: Use of Machine Learning Models to Differentiate Neurodevelopment Conditions Through Digitally Collected Data: Cross-Sectional Questionnaire Study
Use of Machine Learning Models to Differentiate Neurodevelopment Conditions Through Digitally Collected Data: Cross-Sectional Questionnaire Study Open
Background Diagnosis of child and adolescent psychopathologies involves a multifaceted approach, integrating clinical observations, behavioral assessments, medical history, cognitive testing, and familial context information. Digital techn…
View article: Brain Alteration Patterns in Children with Duchenne Muscular Dystrophy: A Machine Learning Approach to Magnetic Resonance Imaging
Brain Alteration Patterns in Children with Duchenne Muscular Dystrophy: A Machine Learning Approach to Magnetic Resonance Imaging Open
Background: Duchenne Muscular Dystrophy (DMD) is a genetic disease in which lack of the dystrophin protein causes progressive muscular weakness, cardiomyopathy and respiratory insufficiency. DMD is often associated with other cognitive and…
View article: Use of Machine Learning Models to Differentiate Neurodevelopment Conditions Through Digitally Collected Data: Cross-Sectional Questionnaire Study (Preprint)
Use of Machine Learning Models to Differentiate Neurodevelopment Conditions Through Digitally Collected Data: Cross-Sectional Questionnaire Study (Preprint) Open
BACKGROUND Diagnosis of child and adolescent psychopathologies involves a multifaceted approach, integrating clinical observations, behavioral assessments, medical history, cognitive testing, and familial context information. Digital tech…
View article: A multimodal approach can identify specific motor profiles in autism and attention‐deficit/hyperactivity disorder
A multimodal approach can identify specific motor profiles in autism and attention‐deficit/hyperactivity disorder Open
It is still unclear whether and to what extent the motor difficulties are specific to autism. This study aimed to determine whether a multimodal assessment of motor skills could accurately discriminate autistic children from attention‐defi…
View article: Enhanced motor noise in an autism subtype with poor motor skills
Enhanced motor noise in an autism subtype with poor motor skills Open
Early motor difficulties are a common in many, but not all, autistic individuals. These difficulties tend to be highly present in individuals carrying rare genetic mutations with high penetrance for autism. Many of these rare genetic mecha…
View article: Exposure to environmental pollutants and attention-deficit/hyperactivity disorder: an overview of systematic reviews and meta-analyses
Exposure to environmental pollutants and attention-deficit/hyperactivity disorder: an overview of systematic reviews and meta-analyses Open
Although heritability estimates suggest a role for genetic components, environmental risk factors have been described as relevant in the etiology of attention deficit/hyperactivity disorder (ADHD). Over the last years several studies have …
View article: Exploring telediagnostic procedures in child neuropsychiatry: addressing ADHD diagnosis and autism symptoms through supervised machine learning
Exploring telediagnostic procedures in child neuropsychiatry: addressing ADHD diagnosis and autism symptoms through supervised machine learning Open
Recently there has been an increase in telemedicine applied to child neuropsychiatry, such as the use of online platforms to remotely collect anamnestic and behavioral information. In the present proof-of-concept study, we aimed to underst…
View article: NIRS Hemodynamic Response to Methylphenidate in Children with Attention Aeficit Hyperactivity Disorder: First Administration, Titration Phase and Associations with Clinical Severity
NIRS Hemodynamic Response to Methylphenidate in Children with Attention Aeficit Hyperactivity Disorder: First Administration, Titration Phase and Associations with Clinical Severity Open
Introduction Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by lack of self-regulation and deficits in organizing behaviors in response to emotional stimuli. Methylphenidate (MPH) is one of t…
View article: Towards telediagnostic procedures in child neuropsychiatry: addressing ADHD diagnosis and autism symptoms through supervised machine learning
Towards telediagnostic procedures in child neuropsychiatry: addressing ADHD diagnosis and autism symptoms through supervised machine learning Open
Recently there has been an increase in telemedicine applied to child neuropsychiatry, such as the use of online platforms to remotely collect anamnestic and behavioral information. In the present proof-of-concept study, we aimed to underst…
View article: Review of: "Cortical activation during cooperative joint actions and competition in children with and without an autism spectrum condition (ASC): an fNIRS study"
Review of: "Cortical activation during cooperative joint actions and competition in children with and without an autism spectrum condition (ASC): an fNIRS study" Open
I am really glad to review the research article entitled "Cortical activation during cooperative joint actions and competition in children with and without an autism spectrum condition (ASC): an fNIRS study".In this study, Su and colleague…
View article: Patterns of Response to Methylphenidate Administration in Children with ADHD: A Personalized Medicine Approach through Clustering Analysis
Patterns of Response to Methylphenidate Administration in Children with ADHD: A Personalized Medicine Approach through Clustering Analysis Open
Individual responses to methylphenidate (MPH) can significantly differ in children with attention-deficit/hyperactivity disorder (ADHD) in terms of the extent of clinical amelioration, optimal dosage needed, possible side effects, and shor…
View article: Crippa et al. 2015 Additional results
Crippa et al. 2015 Additional results Open
Means and standard deviations of Honk Test and Battersea Multitasking Paradigm scores in typically developing children, children with ADHD only, and children with ADHD+ODD.
View article: Crippa et al. 2015 Additional results
Crippa et al. 2015 Additional results Open
Means and standard deviations of Honk Test and Battersea Multitasking Paradigm scores in typically developing children, children with ADHD only, and children with ADHD+ODD.
View article: Data from "Does ACT-Group Training Improve Cognitive Domain in Children with Attention Deficit Hyperactivity Disorder? A Single-Arm, Open-Label Study".
Data from "Does ACT-Group Training Improve Cognitive Domain in Children with Attention Deficit Hyperactivity Disorder? A Single-Arm, Open-Label Study". Open
The present dataset contains the variables referred to the paper "Vanzin, L., Crippa, A., Mauri, V., Valli, A., Mauri, M., Molteni, M., & Nobile, M. (2020). Does ACT-Group Training Improve Cognitive Domain in Children with Attention Defici…
View article: Data from "Does ACT-Group Training Improve Cognitive Domain in Children with Attention Deficit Hyperactivity Disorder? A Single-Arm, Open-Label Study".
Data from "Does ACT-Group Training Improve Cognitive Domain in Children with Attention Deficit Hyperactivity Disorder? A Single-Arm, Open-Label Study". Open
The present dataset contains the variables referred to the paper "Vanzin, L., Crippa, A., Mauri, V., Valli, A., Mauri, M., Molteni, M., & Nobile, M. (2020). Does ACT-Group Training Improve Cognitive Domain in Children with Attention Defici…
View article: Clinical, neuropsychological and NIRS neurophysiological data in children with ADHD and typically developing peers
Clinical, neuropsychological and NIRS neurophysiological data in children with ADHD and typically developing peers Open
The present dataset contains the following variables referred to 43 children participating to a cross sectional study. - ID = subject's identifier - group = subject's group (ctrl=control group, adhd = attention deficit / hyperactivity diso…
View article: Clinical, neuropsychological and NIRS neurophysiological data in children with ADHD and typically developing peers
Clinical, neuropsychological and NIRS neurophysiological data in children with ADHD and typically developing peers Open
The present dataset contains the following variables referred to 43 children participating to a cross sectional study. - ID = subject's identifier - group = subject's group (ctrl=control group, adhd = attention deficit / hyperactivity diso…