Alessandro Loppini
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View article: Role of criticality in the structure-function relationship in the human brain
Role of criticality in the structure-function relationship in the human brain Open
A healthy brain exhibits a rich dynamical repertoire, with flexible spatiotemporal patterns replaying on both microscopic and macroscopic scales. We hypothesize that the observed relationship between empirical structure and functional patt…
View article: Impact of electric spatially discordant alternans on cardiac magnetic field
Impact of electric spatially discordant alternans on cardiac magnetic field Open
Spatially discordant alternans (SDA) play a crucial role in cardiac arrhythmogenesis by creating steep repolarization gradients facilitating conduction block and reentry. While traditionally studied using electrical indicators, this work p…
View article: Impact of Electric Spatially Discordant Alternans on Cardiac Magnetic Field
Impact of Electric Spatially Discordant Alternans on Cardiac Magnetic Field Open
Spatially discordant alternans (SDA) play a crucial role in cardiac arrhythmogenesis by creating steep repolarization gradients facilitating conduction block and reentry. While traditionally studied using electrical indicators, this work p…
View article: Magnetic signature of thermoelectric cardiac dynamics
Magnetic signature of thermoelectric cardiac dynamics Open
Developing methods to predict electromagnetic instabilities in cardiac dynamics is crucial. However, a comprehensive view of the heart's magnetic activity at a tissue scale is still needed. To address such a challenging problem, we present…
View article: A statistical mechanics investigation of unfolded protein response across organisms
A statistical mechanics investigation of unfolded protein response across organisms Open
Living systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed …
View article: A statistical mechanics investigation of Unfolded Protein Response across organisms
A statistical mechanics investigation of Unfolded Protein Response across organisms Open
Living systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed …
View article: A statistical mechanics investigation of Unfolded Protein Response across organisms
A statistical mechanics investigation of Unfolded Protein Response across organisms Open
Living systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed …
View article: Magnetic Signature of Thermo-Electric Cardiac Dynamics
Magnetic Signature of Thermo-Electric Cardiac Dynamics Open
Developing new methods for predicting electromagnetic instabilities in cardiac activity is of primary importance. However, we still need a comprehensive view of the heart's magnetic activity at the tissue scale. To fill this gap, we presen…
View article: A cross species thermoelectric and spatiotemporal analysis of alternans in live explanted hearts using dual voltage-calcium fluorescence optical mapping
A cross species thermoelectric and spatiotemporal analysis of alternans in live explanted hearts using dual voltage-calcium fluorescence optical mapping Open
Objective. Temperature plays a crucial role in influencing the spatiotemporal dynamics of the heart. Electrical instabilities due to specific thermal conditions typically lead to early period-doubling bifurcations and beat-to-beat alternan…
View article: Biophysical modeling of the whole-cell dynamics of C. elegans motor and interneurons families
Biophysical modeling of the whole-cell dynamics of C. elegans motor and interneurons families Open
The nematode Caenorhabditis elegans is a widely used model organism for neuroscience. Although its nervous system has been fully reconstructed, the physiological bases of single-neuron functioning are still poorly explored. Recently, many …
View article: Multilevel synchronization of human β-cells networks
Multilevel synchronization of human β-cells networks Open
β -cells within the endocrine pancreas are fundamental for glucose, lipid and protein homeostasis. Gap junctions between cells constitute the primary coupling mechanism through which cells synchronize their electrical and metabolic activit…
View article: Innovative Characterization of Alternans Onset and Development in Dual Voltage-Calcium Whole-Heart Optical Mapping Signals at Multiple Thermal States
Innovative Characterization of Alternans Onset and Development in Dual Voltage-Calcium Whole-Heart Optical Mapping Signals at Multiple Thermal States Open
Cardiac electrical dynamics show complex space-time instabilities, like period-doubling bifurcation and beat-to-beat alternans, known to occur as pro-arrhythmic phenomena and linked to membrane voltage and intracellular calcium kinetics. B…
View article: Spike propagation mapping reveals effective connectivity and predicts surgical outcome in epilepsy
Spike propagation mapping reveals effective connectivity and predicts surgical outcome in epilepsy Open
Neurosurgical intervention is the best available treatment for selected patients with drug resistant epilepsy. For these patients, surgical planning requires biomarkers that delineate the epileptogenic zone, the brain area that is indispen…
View article: Multiscale Hybrid Modeling of Proteins in Solvent: SARS-CoV2 Spike Protein as Test Case for Lattice Boltzmann — All Atom Molecular Dynamics Coupling
Multiscale Hybrid Modeling of Proteins in Solvent: SARS-CoV2 Spike Protein as Test Case for Lattice Boltzmann — All Atom Molecular Dynamics Coupling Open
Physiological solvent flows surround biological structures triggering therein collective motions. Notable examples are virus/host-cell interactions and solvent-mediated allosteric regulation. The present work describes a multiscale approac…
View article: Structural Controllability to Unveil Hidden Regulation Mechanisms in Unfolded Protein Response: the Role of Network Models
Structural Controllability to Unveil Hidden Regulation Mechanisms in Unfolded Protein Response: the Role of Network Models Open
The Unfolded Protein Response is the cell mechanism for maintaining the balance of properly folded proteins in the endoplasmic reticulum , the specialized cellular compartment. Although it is largely studied from a biological point of view…
View article: Modeling of olfactory transduction in AWC <sup>ON</sup> neuron via coupled electrical-calcium dynamics
Modeling of olfactory transduction in AWC <sup>ON</sup> neuron via coupled electrical-calcium dynamics Open
Amphid wing “C” (AWC) neurons are among the most important and studied neurons of the nematode Caenorhabditis elegans. In this work, we unify the existing electrical and intracellular calcium dynamics descriptions to obtain a biophysically…
View article: Optical Ultrastructure of Large Mammalian Hearts Recovers Discordant Alternans by In Silico Data Assimilation
Optical Ultrastructure of Large Mammalian Hearts Recovers Discordant Alternans by In Silico Data Assimilation Open
Understanding and predicting the mechanisms promoting the onset and sustainability of cardiac arrhythmias represent a primary concern in the scientific and medical communities still today. Despite the long-lasting effort in clinical and ph…
View article: Assessment of tools for RNA secondary structure prediction and extraction: a final-user perspective
Assessment of tools for RNA secondary structure prediction and extraction: a final-user perspective Open
The study of RNA structure is fundamental to clarify the RNA molecular functioning. The flexible RNA nature, the huge number of expressed RNAs, and the variety of functions make it challenging to obtain a quantity of structural information…
View article: Inferring Excitatory and Inhibitory Connections in Neuronal Networks
Inferring Excitatory and Inhibitory Connections in Neuronal Networks Open
The comprehension of neuronal network functioning, from most basic mechanisms of signal transmission to complex patterns of memory and decision making, is at the basis of the modern research in experimental and computational neurophysiolog…
View article: Hubs, diversity, and synchronization in FitzHugh-Nagumo oscillator networks: Resonance effects and biophysical implications
Hubs, diversity, and synchronization in FitzHugh-Nagumo oscillator networks: Resonance effects and biophysical implications Open
Using the FitzHugh-Nagumo equations to represent the oscillatory electrical behavior of β-cells, we develop a coupled oscillator network model with cubic lattice topology, showing that the emergence of pacemakers or hubs in the system can …
View article: Thermal effects on cardiac alternans onset and development: A spatiotemporal correlation analysis
Thermal effects on cardiac alternans onset and development: A spatiotemporal correlation analysis Open
Alternans of cardiac action potential duration represent critical precursors for the development of life-threatening arrhythmias and sudden cardiac death. The system's thermal state affects these electrical disorders requiring additional t…
View article: Biophysics and Modeling of Mechanotransduction in Neurons: A Review
Biophysics and Modeling of Mechanotransduction in Neurons: A Review Open
Mechanosensing is a key feature through which organisms can receive inputs from the environment and convert them into specific functional and behavioral outputs. Mechanosensation occurs in many cells and tissues, regulating a plethora of m…
View article: A Multiscale Approach to Axon and Nerve Stimulation Modeling: A Review
A Multiscale Approach to Axon and Nerve Stimulation Modeling: A Review Open
Electrical nerve fiber stimulation is a technique widely used in prosthetics and rehabilitation, and its study from a computational point of view can be a useful instrument to support experimental tests. In the last years, there was an inc…
View article: Spatiotemporal correlation uncovers characteristic lengths in cardiac tissue
Spatiotemporal correlation uncovers characteristic lengths in cardiac tissue Open
Complex spatiotemporal patterns of action potential duration have been shown to occur in many mammalian hearts due to period-doubling bifurcations that develop with increasing frequency of stimulation. Here, through high-resolution optical…
View article: Biophysical modeling of C. elegans neurons: Single ion currents and whole-cell dynamics of AWCon and RMD
Biophysical modeling of C. elegans neurons: Single ion currents and whole-cell dynamics of AWCon and RMD Open
C. elegans neuronal system constitutes the ideal framework for studying simple, yet realistic, neuronal activity, since the whole nervous system is fully characterized with respect to the exact number of neurons and the neuronal connection…
View article: Critical transitions in heterogeneous networks: Loss of low-degree nodes as an early warning signal
Critical transitions in heterogeneous networks: Loss of low-degree nodes as an early warning signal Open
A large number of real networks show abrupt phase transition phenomena in response to environmental changes. In this case, cascading phenomena can induce drastic and discontinuous changes in the system state and lead to collapse. Although …
View article: Competing Mechanisms of Stress-Assisted Diffusivity and Stretch-Activated Currents in Cardiac Electromechanics
Competing Mechanisms of Stress-Assisted Diffusivity and Stretch-Activated Currents in Cardiac Electromechanics Open
We numerically investigate the role of mechanical stress in modifying the conductivity properties of cardiac tissue, and also assess the impact of these effects in the solutions generated by computational models for cardiac electromechanic…
View article: Thermo-electric effects in an anisotropic active strain electromechanical model
Thermo-electric effects in an anisotropic active strain electromechanical model Open
In this paper we introduce a new mathematical model for the active contraction of the cardiac muscle under different thermo-electric and nonlinear conductivity properties. The passive hyperelastic response of the tissue is described by an …