Alessandro M. Varani
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View article: One Health Genomic Perspective on Pseudescherichia vulneris: A Neglected Reservoir of Last-Resort Resistance Genes
One Health Genomic Perspective on Pseudescherichia vulneris: A Neglected Reservoir of Last-Resort Resistance Genes Open
Antimicrobial resistance (AMR) is a critical global threat, often driven by horizontal gene transfer mediated by mobile genetic elements (MGEs) such as plasmids, transposons, and integrons. Among Enterobacterales, IncHI2/IncHI2A plasmids a…
View article: Integrative chromosome-scale analysis of cupuassu reveals structural and regulatory innovations shaping witches' broom disease resistance and provides a resource for functional studies in Theobroma
Integrative chromosome-scale analysis of cupuassu reveals structural and regulatory innovations shaping witches' broom disease resistance and provides a resource for functional studies in Theobroma Open
View article: The peptide LyeTx I mnΔK induces transcriptomic reprogramming in a novel Multidrug-resistant <i>Acinetobacter baumannii</i>
The peptide LyeTx I mnΔK induces transcriptomic reprogramming in a novel Multidrug-resistant <i>Acinetobacter baumannii</i> Open
Acinetobacter baumannii is a critical pathogen in healthcare-associated infections, and treatment is challenging due to the emergence of multidrug-resistant strains. Antimicrobial peptides, such as LyeTx I mnΔK, a synthetic peptide derived…
View article: Integrative chromosome-scale analysis of cupuassu reveals structural and regulatory innovations shaping witches' broom disease resistance and provides a resource for functional studies in Theobroma
Integrative chromosome-scale analysis of cupuassu reveals structural and regulatory innovations shaping witches' broom disease resistance and provides a resource for functional studies in Theobroma Open
View article: Genome-Resolved In Silico Analysis of Poultry and Swine Lactobacillales Provides a Data- Driven Framework for Elucidating Metabolic Synergies in Multi-Strain Probiotics
Genome-Resolved In Silico Analysis of Poultry and Swine Lactobacillales Provides a Data- Driven Framework for Elucidating Metabolic Synergies in Multi-Strain Probiotics Open
Probiotics are live microorganisms that provide health benefits to the host by improving digestion, enhancing nutrient absorption, and modulating the immune system. Among them, lactic acid bacteria are known for producing vitamins and shor…
View article: Phenotypic and genomic characterization of bacteriocin-producing lactic acid bacteria with probiotic and biotechnological potential for pathogen control in animal production
Phenotypic and genomic characterization of bacteriocin-producing lactic acid bacteria with probiotic and biotechnological potential for pathogen control in animal production Open
The emergence of antibiotic-resistant pathogens has raised significant concerns in the poultry industry, driving the search for alternatives to antibiotics as growth promoters in animal feed. Probiotics, particularly those belonging to the…
View article: Exploring multitasking proteins in Xanthomonas secretomes: Insights into mechanisms of plant-pathogen interactions
Exploring multitasking proteins in Xanthomonas secretomes: Insights into mechanisms of plant-pathogen interactions Open
Recent advances in large-scale functional genomic analysis have significantly increased interest in multitask proteins. The role of these proteins in Xanthomonas phytopathogens, a model for plant-pathogen interaction studies, remains large…
View article: Complex resistance mechanisms in multidrug-resistant Pseudescherichia vulneris from a Healthy Cat: Unveiling genomic architecture and public health implications
Complex resistance mechanisms in multidrug-resistant Pseudescherichia vulneris from a Healthy Cat: Unveiling genomic architecture and public health implications Open
Antimicrobial resistance is a critical global public health challenge. Pseudescherichia vulneris is an opportunistic pathogen that carries resistance genes and can invade and colonize various sites in both humans and animals. In this study…
View article: Bridging the Python Training Gap for Bioscientists in Brazil: Improvements and Challenges
Bridging the Python Training Gap for Bioscientists in Brazil: Improvements and Challenges Open
The rapid evolution of high-throughput technologies in biosciences has generated diverse and voluminous datasets, requiring bioscientists to develop data manipulation and analysis skills. Python, known for its versatility and powerful libr…
View article: Prokaryotic Transposable Elements
Prokaryotic Transposable Elements Open
Prokaryotes have provided an abundance of transposable elements (TEs), which have greatly contributed to our present understanding of the importance of TE in remodeling their host genomes and regulating gene expression, and have been key t…
View article: De novo assembly and characterization of a highly degenerated ZW sex chromosome in the fish Megaleporinus macrocephalus
De novo assembly and characterization of a highly degenerated ZW sex chromosome in the fish Megaleporinus macrocephalus Open
Background Megaleporinus macrocephalus (piauçu) is a Neotropical fish within Characoidei that presents a well-established heteromorphic ZZ/ZW sex-determination system and thus, constitutes a good model for studying W and Z chromosomes in f…
View article: <i>De novo</i> assembly and characterization of a highly degenerated ZW sex chromosome in the fish <i>Megaleporinus macrocephalus</i>
<i>De novo</i> assembly and characterization of a highly degenerated ZW sex chromosome in the fish <i>Megaleporinus macrocephalus</i> Open
Background Megaleporinus macrocephalus (piauçu) is a Neotropical fish within Characoidei that presents a well-established heteromorphic ZZ/ZW sex determination system and thus constitutes a good model for studying W and Z chromosomes in fi…
View article: Genomic decoding of <i>Theobroma grandiflorum</i> (cupuassu) at chromosomal scale: evolutionary insights for horticultural innovation
Genomic decoding of <i>Theobroma grandiflorum</i> (cupuassu) at chromosomal scale: evolutionary insights for horticultural innovation Open
Background Theobroma grandiflorum (Malvaceae), known as cupuassu, is a tree indigenous to the Amazon basin, valued for its large fruits and seed pulp, contributing notably to the Amazonian bioeconomy. The seed pulp is utilized in desserts …
View article: The mitogenomic landscape of Banisteriopsis caapi (Malpighiaceae), the sacred liana used for ayahuasca preparation
The mitogenomic landscape of Banisteriopsis caapi (Malpighiaceae), the sacred liana used for ayahuasca preparation Open
The sacred ayahuasca brew, utilized by indigenous communities in the Amazon and syncretic religious groups in Brazil, primarily consists of a decoction of two plants: (i) the Amazonian liana known as Mariri or Jagube (Banisteriopsis caapi)…
View article: Genomic decoding of<i>Theobroma grandiflorum</i>(cupuassu) at chromosomal scale: Evolutionary insights for horticultural innovation
Genomic decoding of<i>Theobroma grandiflorum</i>(cupuassu) at chromosomal scale: Evolutionary insights for horticultural innovation Open
Background Theobroma grandiflorum (Malvaceae), known as cupuassu, is a tree indigenous to the Amazon Basin, valued for its large fruits and seed-pulp, contributing notably to the Amazonian bioeconomy. The seed-pulp is utilized in desserts …
View article: The insertion sequence excision enhancer: A PrimPol‐based primer invasion system for immobilizing transposon‐transmitted antibiotic resistance genes
The insertion sequence excision enhancer: A PrimPol‐based primer invasion system for immobilizing transposon‐transmitted antibiotic resistance genes Open
Evolutionary studies often identify genes that have been exchanged between different organisms and the phrase Lateral or Horizontal Gene Transfer is often used in this context. However, they rarely provide any mechanistic information conce…
View article: Annotation Data: Decoding the chromosome-scale genome of the nutrient-rich Agaricus subrufescens: A Resource for fungal biology and biotechnology
Annotation Data: Decoding the chromosome-scale genome of the nutrient-rich Agaricus subrufescens: A Resource for fungal biology and biotechnology Open
Decoding the chromosome-scale genome of the nutrient-rich Agaricus subrufescens: A Resource for fungal biology and biotechnology Genome annotation data Genome Browser: https://plantgenomics.ncc.unesp.br/ge…
View article: Annotation Data: Decoding the chromosome-scale genome of the nutrient-rich Agaricus subrufescens: A Resource for fungal biology and biotechnology
Annotation Data: Decoding the chromosome-scale genome of the nutrient-rich Agaricus subrufescens: A Resource for fungal biology and biotechnology Open
Decoding the chromosome-scale genome of the nutrient-rich Agaricus subrufescens: A Resource for fungal biology and biotechnology Genome annotation data Genome Browser: https://plantgenomics.ncc.unesp.br/ge…
View article: The Insertion Sequence Excision Enhancer (IEE): a PrimPol-based system for Immobilizing Transposon-Transmitted Antibiotic Resistance Genes?
The Insertion Sequence Excision Enhancer (IEE): a PrimPol-based system for Immobilizing Transposon-Transmitted Antibiotic Resistance Genes? Open
Evolutionary studies often identify genes that are shared between different organisms and the phrase Lateral or Horizontal Gene Transfer is often used in this context. However, they rarely provide any mechanistic information concerning how…
View article: The Insertion Sequence Excision Enhancer (IEE): a PrimPol-based system for Immobilizing Transposon-Transmitted Antibiotic Resistance Genes?
The Insertion Sequence Excision Enhancer (IEE): a PrimPol-based system for Immobilizing Transposon-Transmitted Antibiotic Resistance Genes? Open
We provide an overview of a protein, IEE (Insertion Sequence Excision Enhancer), which was originally observed to facilitate high levels of excision of the IS3 family member, IS629, from clinically important Escherichia coli O157:H7. IEE w…
View article: AB1565 IBD AND LIGAMENTOUS LAXITY ASSOCIATION
AB1565 IBD AND LIGAMENTOUS LAXITY ASSOCIATION Open
View article: Decoding the chromosome-scale genome of the nutrient-rich Agaricus subrufescens: A Resource for fungal biology and biotechnology.
Decoding the chromosome-scale genome of the nutrient-rich Agaricus subrufescens: A Resource for fungal biology and biotechnology. Open
Agaricus subrufescens , also known as the “mushroom of the sun,” has significant nutritional and medicinal value. However, its short shelf life due to the browning process results in post-harvest losses unless it’s quickly dehydrated. This…
View article: The phylogenomics and evolutionary dynamics of the organellar genomes in carnivorous Utricularia and Genlisea species (Lentibulariaceae)
The phylogenomics and evolutionary dynamics of the organellar genomes in carnivorous Utricularia and Genlisea species (Lentibulariaceae) Open
View article: Comparative genomics study of Staphylococcus aureus isolated from cattle and humans reveals virulence patterns exclusively associated with bovine clinical mastitis strains
Comparative genomics study of Staphylococcus aureus isolated from cattle and humans reveals virulence patterns exclusively associated with bovine clinical mastitis strains Open
Staphylococcus aureus causes nosocomial and intramammary infections in humans and cattle, respectively. A large number of virulence factors are thought to play important roles in the pathogenesis of this bacterium. Currently, genome-wide a…
View article: The complete organellar genomes of the entheogenic plant <i>Psychotria viridis</i> (Rubiaceae), a main component of the ayahuasca brew
The complete organellar genomes of the entheogenic plant <i>Psychotria viridis</i> (Rubiaceae), a main component of the ayahuasca brew Open
Psychotria viridis (Rubioideae: Rubiaceae), popularly known as chacrona , is commonly found as a shrub in the Amazon region and is well-known to produce psychoactive compounds, such as the N,N-dimethyltryptamine (DMT). Together with the li…
View article: Phylogenomic characterization and pangenomic insights into the surfactin-producing bacteria Bacillus subtilis strain RI4914
Phylogenomic characterization and pangenomic insights into the surfactin-producing bacteria Bacillus subtilis strain RI4914 Open
View article: First Report of Bartonella spp. in Marsupials from Brazil, with a Description of Bartonella harrusi sp. nov. and a New Proposal for the Taxonomic Reclassification of Species of the Genus Bartonella
First Report of Bartonella spp. in Marsupials from Brazil, with a Description of Bartonella harrusi sp. nov. and a New Proposal for the Taxonomic Reclassification of Species of the Genus Bartonella Open
The genus Bartonella (Rhizobiales: Bartonellaceae) encompasses facultative intracellular Gram-negative alphaproteobacteria that parasitize mainly erythrocytes and endothelial cells, as well as macrophages, monocytes and dendritic cells. Al…
View article: Characterization of Lactiplantibacillus plantarum Tw226 strain and its use for the production of a new membrane-bound biosurfactant
Characterization of Lactiplantibacillus plantarum Tw226 strain and its use for the production of a new membrane-bound biosurfactant Open