Alessandro Negri
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View article: The phi027 Bacteriophage Influences Physiology and Virulence of the Lysogenic Strain of <em>Clostridioides difficile</em>
The phi027 Bacteriophage Influences Physiology and Virulence of the Lysogenic Strain of <em>Clostridioides difficile</em> Open
Clostridioides difficile, the causative agent of C. difficile infections (CDI), can be naturally infected by bacterial viruses known as bacteriophages. All characterized bacteriophages of this bacterium are temperate, meaning that upon inf…
View article: Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis
Matrix Metalloproteinases in the Periodontium—Vital in Tissue Turnover and Unfortunate in Periodontitis Open
The extracellular matrix (ECM) is a complex non-cellular three-dimensional macromolecular network present within all tissues and organs, forming the foundation on which cells sit, and composed of proteins (such as collagen), glycosaminogly…
View article: From the Classification of Stem Cells to the Release of Potential in Cell Therapies: Limits, Considerations and Future Aspects in Regenerative Medicine
From the Classification of Stem Cells to the Release of Potential in Cell Therapies: Limits, Considerations and Future Aspects in Regenerative Medicine Open
Regenerative medicine aims to repair organs or tissues that have congenital abnormalities, or that have been damaged by disease, aging, or trauma, and to restore or at least improve their native function. One of the strategies used in rege…
View article: Biometric characterization of the Red-legged Partridges <i>Alectoris rufa</i> of northwestern Italy
Biometric characterization of the Red-legged Partridges <i>Alectoris rufa</i> of northwestern Italy Open
The biometrics of the Red-legged Partridge Alectoris rufa has been relatively well studied in the western part of its distribution range (Iberian Peninsula and France), especially due to the available large hunting bag samples. Conversely,…
View article: Regulator-dependent temporal dynamics of a restriction-modification system's gene expression upon entering new host cells: single-cell and population studies
Regulator-dependent temporal dynamics of a restriction-modification system's gene expression upon entering new host cells: single-cell and population studies Open
Restriction-modification (R-M) systems represent a first line of defense against invasive DNAs, such as bacteriophage DNAs, and are widespread among bacteria and archaea. By acquiring a Type II R-M system via horizontal gene transfer, the …
View article: Complete genome sequence of a clinical isolate of Clostridioides difficile bacteriophage phiCDKH01 of the family Siphoviridae
Complete genome sequence of a clinical isolate of Clostridioides difficile bacteriophage phiCDKH01 of the family Siphoviridae Open
A new temperate phiCDKH01 siphophage was obtained from clinical isolate of Clostridioides difficile. The phage genome is a 45,089 bp linear double-stranded DNA molecule with an average G + C content of 28.7%. It shows low similarity to kno…
View article: Additional file of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment
Additional file of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment Open
Additional file of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment
View article: Additional file 4 of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment
Additional file 4 of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment Open
Additional file 4:Supplementary file 3. Additional information to Figure 6. GO terms used to generate multi level pie charts shown in Figure 6. (XLS 22 KB)
View article: Additional file of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment
Additional file of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment Open
Additional file of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment
View article: Additional file 3 of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment
Additional file 3 of Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment Open
Additional file 3:GO term over-representation analysis. (XLS 40 KB)
View article: Transcriptome analyses of cells carrying the Type II Csp231I restriction–modification system reveal cross-talk between two unrelated transcription factors: C protein and the Rac prophage repressor
Transcriptome analyses of cells carrying the Type II Csp231I restriction–modification system reveal cross-talk between two unrelated transcription factors: C protein and the Rac prophage repressor Open
Restriction-modification (R–M) systems represent an effective mechanism of defence against invading bacteriophages, and are widely spread among bacteria and archaea. In acquiring a Type II R–M system via horizontal gene transfer, the new h…
View article: IL-1 Fragment Modulates Immune Response Elicited by Recombinant Bacillus subtilis Spores Presenting an Antigen/Adjuvant Chimeric Protein
IL-1 Fragment Modulates Immune Response Elicited by Recombinant Bacillus subtilis Spores Presenting an Antigen/Adjuvant Chimeric Protein Open
Mucosal immunizations are convenient ways of vaccination, which do not require any trained personnel for administration. One of the major challenges for developing an effective mucosal vaccine is finding appropriate adjuvant. Bacillus subt…
View article: The choice of anchoring protein influences interaction of recombinant Bacillus spores with the immune system
The choice of anchoring protein influences interaction of recombinant Bacillus spores with the immune system Open
The technology of display of heterologous proteins on the surface of Bacillus subtilis spores enables use of these structures as carriers of antigens for mucosal vaccination. Currently there are no technical possibilities to predict, wheth…