Alessandro Pezzella
YOU?
Author Swipe
View article: In Vitro Osteogenic Stimulation of Human Adipose-Derived MSCs on Biofunctional 3D-Printed Scaffolds
In Vitro Osteogenic Stimulation of Human Adipose-Derived MSCs on Biofunctional 3D-Printed Scaffolds Open
Background: Human adipose-derived mesenchymal stem cells (hADMSCs) are widely used in regenerative medicine due to their ability to proliferate and differentiate. Bone tissue engineering represents an innovative alternative to traditional …
View article: In-Depth Analysis of the Paramagnetic Properties in DHI/DHICA-Controlled Eumelanin
In-Depth Analysis of the Paramagnetic Properties in DHI/DHICA-Controlled Eumelanin Open
Eumelanin, a naturally occurring pigment derived from the oxidative polymerization of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA), has been extensively studied for its role in human biology and its potential…
View article: Impact of Parabacteroides distasonis colonization on host microbiome, metabolome, immunity, and diabetes onset
Impact of Parabacteroides distasonis colonization on host microbiome, metabolome, immunity, and diabetes onset Open
Type 1 diabetes (T1D) is caused by autoimmune destruction of pancreatic β-cells. The insulin B-chain 9–23 (insB9–23) peptide is a critical epitope in triggering T1D. In our previous study, we showed that Parabacteroides distasonis , a huma…
View article: The Impact of Parabacteroides distasonis Colonization on Hosts' Microbiome, Metabolome, Immune Responses, and Diabetes Onset
The Impact of Parabacteroides distasonis Colonization on Hosts' Microbiome, Metabolome, Immune Responses, and Diabetes Onset Open
Type 1 Diabetes (T1D) is a chronic disease caused by autoimmune destruction of insulin-producing pancreatic β-cells. The insulin B-chain 9-23 (insB:9-23) peptide is established as a critical epitope in triggering T1D. In our previous study…
View article: Phenolic driven decoration of silica with Ag nanoparticles: Towards sustainable water remediation
Phenolic driven decoration of silica with Ag nanoparticles: Towards sustainable water remediation Open
The development of effective systems for the removal of toxic compounds from wastewater is an important goal in the production of materials for environmental applications. In this work we report a sustainable approach for the design and de…
View article: Cyan Hydrogen Process: A New Route for Simultaneous Hydrogen Production and Carbon Valorization
Cyan Hydrogen Process: A New Route for Simultaneous Hydrogen Production and Carbon Valorization Open
Hydrogen is expected to largely contribute to the near-future circular economy. Today, most hydrogen is still produced from fossil fuels or renewable pathways with low efficiency and high cost. Herein, a proof of concept for a novel hydrog…
View article: Designing bioinspired multifunctional nanoplatforms to support wound healing and skin regeneration: Mg-hydroxyapatite meets melanins
Designing bioinspired multifunctional nanoplatforms to support wound healing and skin regeneration: Mg-hydroxyapatite meets melanins Open
Melanin is a multifunctional biological pigment that recently emerged as endowed with anti-inflammatory, antioxidant, and antimicrobial properties and with high potentialities in skin protection and regenerative medicine. Here, a biomimeti…
View article: A synergistic radical concentration increase in eumelanin–PEDOT:PSS blends: mammalian pigment-based doping for thermopower improvement
A synergistic radical concentration increase in eumelanin–PEDOT:PSS blends: mammalian pigment-based doping for thermopower improvement Open
The impact of eumelanin integration into PEDOT:PSS is explored here by means of in-depth electron paramagnetic resonance measurements to shed light on the possible contribution of the mammalian pigment to thermopower improvement of PEDOT:P…
View article: Enhanced Photoacoustic Response by Synergistic Ag–Melanin Interplay at the Core of Ternary Biocompatible Hybrid Silica-Based Nanoparticles
Enhanced Photoacoustic Response by Synergistic Ag–Melanin Interplay at the Core of Ternary Biocompatible Hybrid Silica-Based Nanoparticles Open
Photoacoustics (PA) is gaining increasing credit among biomolecular imaging methodologies by virtue of its poor invasiveness, deep penetration, high spatial resolution, and excellent endogenous contrast, without the use of any ionizing rad…
View article: Nanoparticle Coatings on Glass Surfaces to Prevent Pseudomonas fluorescens AR 11 Biofilm Formation
Nanoparticle Coatings on Glass Surfaces to Prevent Pseudomonas fluorescens AR 11 Biofilm Formation Open
Microbial colonization of surfaces is a sanitary and industrial issue for many applications, leading to product contamination and human infections. When microorganisms closely interact with a surface, they start to produce an exo-polysacca…
View article: Eumelanin‐Coated Aligned PLA Electrospun Microfibers to Guide SH‐SY5YCells Spreading, Alignment, And Maturation
Eumelanin‐Coated Aligned PLA Electrospun Microfibers to Guide SH‐SY5YCells Spreading, Alignment, And Maturation Open
During the development of the nervous system, neurons sense and respond to topographical and biochemical cues found in the brain's native environment. Such niche‐specific cues are pivotal for neural tissue formation and development and hav…
View article: Bioactive Composite Methacrylated Gellan Gum for 3D-Printed Bone Tissue-Engineered Scaffolds
Bioactive Composite Methacrylated Gellan Gum for 3D-Printed Bone Tissue-Engineered Scaffolds Open
Gellan gum (GG) was chemically modified with methacrylic moieties to produce a photocrosslinkable biomaterial ink, hereinafter called methacrylated GG (GGMA), with improved physico-chemical properties, mechanical behavior and stability und…
View article: Cyan H2: A New Route for Simultaneous Hydrogen Production and Carbon Valorisation
Cyan H2: A New Route for Simultaneous Hydrogen Production and Carbon Valorisation Open
View article: Insights into the Electrical Characterization of Graphene-like Materials from Carbon Black
Insights into the Electrical Characterization of Graphene-like Materials from Carbon Black Open
A new class of graphene-related materials (GRMs) obtained as water suspensions through a two-step oxidation/reduction of a nanostructured carbon black, namely graphene-like (GL) materials, has recently emerged. GL materials undergo self-as…
View article: Eumelanin from the Black Soldier Fly as Sustainable Biomaterial: Characterisation and Functional Benefits in Tissue-Engineered Composite Scaffolds
Eumelanin from the Black Soldier Fly as Sustainable Biomaterial: Characterisation and Functional Benefits in Tissue-Engineered Composite Scaffolds Open
An optimized extraction protocol for eumelanins from black soldier flies (BSF-Eumel) allows an in-depth study of natural eumelanin pigments, which are a valuable tool for the design and fabrication of sustainable scaffolds. Here, water-sol…
View article: The interplay of chemical structure, physical properties, and structural design as a tool to modulate the properties of melanins within mesopores
The interplay of chemical structure, physical properties, and structural design as a tool to modulate the properties of melanins within mesopores Open
The design of modern devices that can fulfil the requirements for sustainability and renewable energy applications calls for both new materials and a better understanding of the mixing of existing materials. Among those, surely organic–ino…
View article: Eumelanin pigment precursor 2-carboxy-5,6-dihydroxyindole and 2-amino-6-methylbenzothiazole chromophore integration towards melanin inspired chemoresponsive materials: the case of the Zn<sup>2+</sup> ion
Eumelanin pigment precursor 2-carboxy-5,6-dihydroxyindole and 2-amino-6-methylbenzothiazole chromophore integration towards melanin inspired chemoresponsive materials: the case of the Zn<sup>2+</sup> ion Open
The 2-amino-6-methylbenzothiazole chromophore is introduced at the carboxyl group of the melanin precursor 2-carboxy-5,6-dihydroxyindole achieving a novel dihydroxyindole derivative with metal chelation properties not involving the catecho…
View article: Promelanogenic Effects by an Annurca Apple-Based Natural Formulation in Human Primary Melanocytes
Promelanogenic Effects by an Annurca Apple-Based Natural Formulation in Human Primary Melanocytes Open
Disposal of skin pigmenting agents would be attractive for the treatment of hypopigmentation disorders, to postpone skin photoaging or simply for fashion, so that discovery and development of melanogenesis stimulators, especially from natu…
View article: En Route to a Chiral Melanin: The Dynamic “From-Imprinted-to-Template” Supramolecular Role of Porphyrin Hetero-Aggregates During the Oxidative Polymerization of L-DOPA
En Route to a Chiral Melanin: The Dynamic “From-Imprinted-to-Template” Supramolecular Role of Porphyrin Hetero-Aggregates During the Oxidative Polymerization of L-DOPA Open
Chiral porphyrin hetero-aggregates, produced from meso-tetrakis(4-N-methylpyridyl) porphyrin H 2 T4 and copper(II) meso-tetrakis(4-sulfonatophenyl)porphyrin CuTPPS by an imprinting effect in the presence of L-3,4-dihydroxyphenylalanine (L-…
View article: Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine
Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine Open
Melanins are a group of dark insoluble pigments found widespread in nature. In mammals, the brown-black eumelanins and the reddish-yellow pheomelanins are the main determinants of skin, hair, and eye pigmentation and play a significant rol…
View article: Albumin-Modified Melanin-Silica Hybrid Nanoparticles Target Breast Cancer Cells via a SPARC-Dependent Mechanism
Albumin-Modified Melanin-Silica Hybrid Nanoparticles Target Breast Cancer Cells via a SPARC-Dependent Mechanism Open
Bioconjugation of a recently developed photoacoustic nanoprobe, based on silica-templated eumelanin-silver hybrid nanoparticles (MelaSil_Ag-NPs), with human serum albumin (HSA) is disclosed herein as an efficient and practical strategy to …
View article: Eumelanin Precursor 2-Carboxy-5,6-Dihydroxyindole (DHICA) as Doping Factor in Ternary (PEDOT:PSS/Eumelanin) Thin Films for Conductivity Enhancement
Eumelanin Precursor 2-Carboxy-5,6-Dihydroxyindole (DHICA) as Doping Factor in Ternary (PEDOT:PSS/Eumelanin) Thin Films for Conductivity Enhancement Open
The integration of the pristine not-doped commercial poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) PH1000 with eumelanin, the brown to black kind of melanin pigment, was achieved by dissolving the melanogenic precurso…
View article: Relation between Local Structure, Electric Dipole, and Charge Carrier Dynamics in DHICA Melanin: A Model for Biocompatible Semiconductors
Relation between Local Structure, Electric Dipole, and Charge Carrier Dynamics in DHICA Melanin: A Model for Biocompatible Semiconductors Open
Eumelanins are a family of natural and synthetic pigments obtained by oxidative polymerization of their natural precursors: 5,6-dihydroxyindole and its 2-carboxy derivative (DHICA). The simultaneous presence of ionic and electronic charge …
View article: Relation Between Local Structure, Electric Dipole and Charge Carrier Dynamics in DHICA Melanin, a Model for Biocompatible Semiconductors
Relation Between Local Structure, Electric Dipole and Charge Carrier Dynamics in DHICA Melanin, a Model for Biocompatible Semiconductors Open
Eumelanins are a family of natural and synthetic pigments obtained by oxidative polymerization of their natural precursors: 5,6 dihydroxyindole and its 2-carboxy derivative (DHICA). The simultaneous presence of ionic and electronic charge …
View article: Relation Between Local Structure, Electric Dipole and Charge Carrier Dynamics in DHICA Melanin, a Model for Biocompatible Semiconductors
Relation Between Local Structure, Electric Dipole and Charge Carrier Dynamics in DHICA Melanin, a Model for Biocompatible Semiconductors Open
Eumelanins are a family of natural and synthetic pigments obtained by oxidative polymerization of their natural precursors: 5,6 dihydroxyindole and its 2-carboxy derivative (DHICA). The simultaneous presence of ionic and electronic charge …
View article: Titanium based complexes with melanin precursors as a tool for directing melanogenic pathways
Titanium based complexes with melanin precursors as a tool for directing melanogenic pathways Open
Bioinspired melanin based hybrid materials hold huge promise for developing multifunctional systems for a considerable set of applications. Yet, control of melanogenic pathway is a big challenge to allow rational design of nanostructured s…
View article: Silver-nanoparticles as plasmon-resonant enhancers for eumelanin's photoacoustic signal in a self-structured hybrid nanoprobe
Silver-nanoparticles as plasmon-resonant enhancers for eumelanin's photoacoustic signal in a self-structured hybrid nanoprobe Open
Developing safe and high efficiency contrast tools is an urgent need to allow in vivo applications of photoacoustics (PA), an emerging biomolecular imaging methodology, with poor invasiveness, deep penetration, high spatial resolution and …
View article: Evidence of Unprecedented High Electronic Conductivity in Mammalian Pigment Based Eumelanin Thin Films After Thermal Annealing in Vacuum
Evidence of Unprecedented High Electronic Conductivity in Mammalian Pigment Based Eumelanin Thin Films After Thermal Annealing in Vacuum Open
Melanin denotes a variety of mammalian pigments, including the dark electrically conductive eumelanin and the reddish, sulfur-containing, pheomelanin. Organic (bio)electronics is showing increasing interests in eumelanin exploitation, e.g.…
View article: Eumelanin Graphene-Like Integration: The Impact on Physical Properties and Electrical Conductivity
Eumelanin Graphene-Like Integration: The Impact on Physical Properties and Electrical Conductivity Open
The recent development of eumelanin pigment-based blends integrating "classical" organic conducting materials is expanding the scope of eumelanin in bioelectronics. Beyond the achievement of high conductivity level, another major goal lays…
View article: Eumelanin for nature‐inspired UV‐absorption enhancement of plastics
Eumelanin for nature‐inspired UV‐absorption enhancement of plastics Open
In the human body, the black‐brown biopigment eumelanin blocks harmful ultraviolet (UV) radiation. In the plastics industry, additives are often added to polymers to increase their UV‐absorption properties. We herein report an assessment o…