Alessandro Salvi
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View article: Determination of longitudinal Circulating levels of miR-21-5p, miR-23b-3p and miR-34a-5p in plasma of patients with glioblastoma using droplet digital PCR
Determination of longitudinal Circulating levels of miR-21-5p, miR-23b-3p and miR-34a-5p in plasma of patients with glioblastoma using droplet digital PCR Open
View article: miR-23b-3p, miR-126-3p and GAS5 delivered by extracellular vesicles inhibit breast cancer xenografts in zebrafish
miR-23b-3p, miR-126-3p and GAS5 delivered by extracellular vesicles inhibit breast cancer xenografts in zebrafish Open
Our study demonstrated that sorafenib-induced EVs, enriched with specific tumor-suppressor ncRNAs, can effectively inhibit the aggressive BC characteristics in vitro and in vivo. Our findings indicate an alternative way to enrich EVs with …
View article: Plasma NfL, GFAP, amyloid, and p-tau species as Prognostic biomarkers in Parkinson’s disease
Plasma NfL, GFAP, amyloid, and p-tau species as Prognostic biomarkers in Parkinson’s disease Open
View article: Dysregulation of a Subset of Circulating and Vesicle-Associated miRNA in Pancreatic Cancer
Dysregulation of a Subset of Circulating and Vesicle-Associated miRNA in Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplasia, characterized by early metastasis, low diagnostic rates at early stages, resistance to drugs, and poor prognosis. There is an urgent need to better characteri…
View article: Evaluation of DNA methylation levels of <i>SEPT9</i> and <i>SHOX2</i> in plasma of patients with head and neck squamous cell carcinoma using droplet digital PCR
Evaluation of DNA methylation levels of <i>SEPT9</i> and <i>SHOX2</i> in plasma of patients with head and neck squamous cell carcinoma using droplet digital PCR Open
Head and neck squamous cell carcinoma (HNSCC) is the seventh most commonly diagnosed cancer globally. HNSCC develops from the mucosa of the oral cavity, pharynx and larynx. Methylation levels of septin 9 (SEPT9) and short stature ho…
View article: Back to the Past. The paleogeography as key to understand the Middle Palaeolithic peopling at Grotta dei Santi (Mt Argentario – Tuscany)
Back to the Past. The paleogeography as key to understand the Middle Palaeolithic peopling at Grotta dei Santi (Mt Argentario – Tuscany) Open
The mobility of hunter-gatherer groups is crucial in understanding Palaeolithic settlement dynamics. The concept of mobility cannot be separated from the space in which it occurs, including landscape components, localization of critical re…
View article: The Biological Role and Translational Implications of the Long Non-Coding RNA GAS5 in Breast Cancer
The Biological Role and Translational Implications of the Long Non-Coding RNA GAS5 in Breast Cancer Open
The lncRNA GAS5 plays a significant role in tumorigenicity and progression of breast cancer (BC). In this review, we first summarize the role of GAS5 in cell biology, focusing on its expression data in human normal tissues. We present data…
View article: Droplet Digital PCR Development To Quantify the DNA Meth-Ylation Levels of SEPT9 and SHOX2 in Plasma From Patients With Head and Neck Squamous Cell Carcinoma
Droplet Digital PCR Development To Quantify the DNA Meth-Ylation Levels of SEPT9 and SHOX2 in Plasma From Patients With Head and Neck Squamous Cell Carcinoma Open
Head and neck squamous cell carcinomas (HNSCCs) develop from the mucosa of the oral cavity, pharynx, and larynx. The methylation levels of Septin 9 (SEPT9) and short stature homeobox 2 (SHOX2) genes in ccfDNA are considered pan-cancer biom…
View article: Lasp1 Expression Is Implicated in Embryonic Development of Zebrafish
Lasp1 Expression Is Implicated in Embryonic Development of Zebrafish Open
The LIM and SH3 domain protein 1 (LASP1) was originally identified in metastatic breast cancer and mainly characterized as a cytoskeleton protein overexpressed in various cancer types. At present, little is known about LASP1 expression in …
View article: Molecular profile of the <scp>NF‐κB</scp> signalling pathway in human colorectal cancer
Molecular profile of the <span>NF‐κB</span> signalling pathway in human colorectal cancer Open
The development and progression of colorectal cancer (CRC) have been associated with inflammation processes that involve the overactivation of the NF‐κB signalling pathway. The characterization of the NF‐κB expression profile in CRC is an …
View article: Expression of Cellular and Extracellular TERRA, TERC and TERT in Hepatocellular Carcinoma
Expression of Cellular and Extracellular TERRA, TERC and TERT in Hepatocellular Carcinoma Open
Non-coding RNAs are transcribed from telomeres and the telomeric repeat-containing RNAs (TERRA) are implicated in telomere homeostasis and in cancer. In this study, we aimed to assess in hepatocellular carcinoma (HCC) the cellular and extr…
View article: Longitudinal Circulating Levels of miR-23b-3p, miR-126-3p and lncRNA GAS5 in HCC Patients Treated with Sorafenib
Longitudinal Circulating Levels of miR-23b-3p, miR-126-3p and lncRNA GAS5 in HCC Patients Treated with Sorafenib Open
Human hepatocellular carcinoma (HCC) is the most frequent primary tumor of the liver and the third cause of cancer-related deaths. The multikinase inhibitor sorafenib is a systemic drug for unresectable HCC. The identification of molecular…
View article: Crosstalk Between DNA Methylation and Gene Mutations in Colorectal Cancer
Crosstalk Between DNA Methylation and Gene Mutations in Colorectal Cancer Open
Colorectal cancer (CRC) is often characterized by mutations and aberrant DNA methylation within the promoters of tumor suppressor genes and proto-oncogenes. The most frequent somatic mutations occur within KRAS and BRAF genes. Mutations of…
View article: H-ferritin suppression and pronounced mitochondrial respiration make Hepatocellular Carcinoma cells sensitive to RSL3-induced ferroptosis
H-ferritin suppression and pronounced mitochondrial respiration make Hepatocellular Carcinoma cells sensitive to RSL3-induced ferroptosis Open
View article: DNA methylation variations in familial female and male breast cancer
DNA methylation variations in familial female and male breast cancer Open
In total, ~25% of familial breast cancer (BC) is attributed to germline mutations of the BRCA1 and BRCA2 genes, while the rest of the cases are included in the BRCAX group. BC is also known to affect men, with a worldwide incidence of 1%. …
View article: Circulating microRNA-23b-3p and tissue microRNA-193a-3p as promising molecular biomarkers in human hepatocellular carcinoma
Circulating microRNA-23b-3p and tissue microRNA-193a-3p as promising molecular biomarkers in human hepatocellular carcinoma Open
View article: MicroRNA‑34a‑5p expression in the plasma and in its extracellular vesicle fractions in subjects with Parkinson's disease: An exploratory study
MicroRNA‑34a‑5p expression in the plasma and in its extracellular vesicle fractions in subjects with Parkinson's disease: An exploratory study Open
Parkinson's disease (PD) is an important disabling age‑related disorder and is the second most common neurodegenerative disease. Currently, no established molecular biomarkers exist for the early diagnosis of PD. Circulating microRNAs (miR…
View article: Inherited duplication of the pseudoautosomal region Xq28 in a subject with Gilles de la Tourette syndrome and intellectual disability: a case report
Inherited duplication of the pseudoautosomal region Xq28 in a subject with Gilles de la Tourette syndrome and intellectual disability: a case report Open
View article: Circulating microRNAs as promising non-invasive molecular biomarkers of HCC
Circulating microRNAs as promising non-invasive molecular biomarkers of HCC Open
View article: miRNAs‐Based Molecular Signature for <i>KRAS</i> Mutated and Wild Type Colorectal Cancer: An Explorative Study
miRNAs‐Based Molecular Signature for <i>KRAS</i> Mutated and Wild Type Colorectal Cancer: An Explorative Study Open
microRNAs (miRNAs) have been proposed as promising molecular biomarkers for diagnosis, prognosis, and responsive therapeutic targets in different types of cancer, including colorectal cancer (CRC). In this study, we evaluated the expressio…
View article: Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy
Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to MicroRNA-34a-5p/Sirt1 Axis and Autophagy Open
Melatonin, an indole produced by pineal and extrapineal tissues, but also taken with a vegetarian diet, has strong anti-oxidant, anti-inflammatory and anti-obesogenic potentials. Non-alcoholic fatty liver disease (NAFLD) is the hepatic sid…
View article: Differential expression profiling of long non-coding RNA GAS5 and miR-126-3p in human cancer cells in response to sorafenib
Differential expression profiling of long non-coding RNA GAS5 and miR-126-3p in human cancer cells in response to sorafenib Open
Long non-coding RNAs (lncRNAs) and microRNAs are involved in numerous physio-pathological conditions included cancer. To better understand the molecular mechanism of the oral antitumor multikinase inhibitor sorafenib, we profiled the expre…
View article: [Corrigendum] Analysis of a nanoparticle‑enriched fraction of plasma reveals miRNA candidates for Down syndrome pathogenesis
[Corrigendum] Analysis of a nanoparticle‑enriched fraction of plasma reveals miRNA candidates for Down syndrome pathogenesis Open
After the publication of the above paper, the authors noted that the names of a couple of the authors listed on the paper were associated with the wrong affliation: Specifically, the eighth and ninth listed authors, Francesca Antonaros and…
View article: Analysis of a nanoparticle‑enriched fraction of plasma reveals miRNA candidates for Down syndrome pathogenesis
Analysis of a nanoparticle‑enriched fraction of plasma reveals miRNA candidates for Down syndrome pathogenesis Open
Down syndrome (DS) is caused by the presence of part or all of a third copy of chromosome 21. DS is associated with several phenotypes, including intellectual disability, congenital heart disease, childhood leukemia and immune defects. Spe…
View article: Long non-coding RNA GAS5 and miR-126-3p as molecular biomarkers of response to sorafenib in human cancer cells.
Long non-coding RNA GAS5 and miR-126-3p as molecular biomarkers of response to sorafenib in human cancer cells. Open
lncRNAs and microRNAs are implicated in several biological functions and their dysregulation is frequently found in cancer. To better understand the molecular mechanism of the multikinase inhibitor sorafenib, we profiled the expression of …
View article: Functional Role of microRNA-23b-3p in Cancer Biology
Functional Role of microRNA-23b-3p in Cancer Biology Open
MicroRNAs (miRNAs) constitute a class of short non coding RNAs that have crucial biological roles by acting mainly as negative regulators of gene expression. The alteration of miRNAs expression has been frequently demonstrated in cancer. F…
View article: Circulating miR-106b-3p, miR-101-3p and miR-1246 as diagnostic biomarkers of hepatocellular carcinoma
Circulating miR-106b-3p, miR-101-3p and miR-1246 as diagnostic biomarkers of hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is the most common liver cancer and second leading cause of cancer related death worldwide. Most HCCs occur in a damaged cirrhotic background and it may be difficult to discriminate between regenerative nodul…
View article: Sorafenib induces variations of the DNA methylome in HA22T/VGH human hepatocellular carcinoma-derived cells
Sorafenib induces variations of the DNA methylome in HA22T/VGH human hepatocellular carcinoma-derived cells Open
Sorafenib is currently used to treat advanced and/or unresectable hepatocellular carcinoma (HCC), but the increase of the median survival was only 3 months. Moreover, sorafenib has severe side effects and patients develop resistance quickl…
View article: Biological Function of MicroRNA193a-3p in Health and Disease
Biological Function of MicroRNA193a-3p in Health and Disease Open
MicroRNAs (miRNAs) are a class of small noncoding RNAs that act mainly as negative regulators of gene expression. Several studies demonstrated that miRNAs take part in numerous biological processes, such as proliferation, apoptosis, and mi…
View article: Clinical and biological significance of miR-23b and miR-193a in human hepatocellular carcinoma
Clinical and biological significance of miR-23b and miR-193a in human hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is the most common cancer of the liver with a very poor prognosis. The dysregulation of microRNAs (miRs) is indeed implicated in HCC onset and progression. In this study, we have evaluated the expression of m…