Alessandro Vindigni
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View article: On the spontaneous magnetization of two-dimensional ferromagnets.
On the spontaneous magnetization of two-dimensional ferromagnets. Open
Ferromagnetism is typically discussed in terms of the exchange interaction and magnetic anisotropies. Yet real samples are inevitably affected by the magnetostatic dipole-dipole interaction. Because of this interaction, a theorem [R.B. Gri…
View article: On the spontaneous magnetization of two-dimensional ferromagnets
On the spontaneous magnetization of two-dimensional ferromagnets Open
Ferromagnetism is typically discussed in terms of the exchange interaction and magnetic anisotropies. Yet real samples are inevitably affected by the magnetostatic dipole-dipole interaction. Because of this interaction, a theorem (R.B. Gri…
View article: CCDC 1947719: Experimental Crystal Structure Determination
CCDC 1947719: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability
Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability Open
Translesion synthesis is a cancer adaptation that suppresses replication stress–induced gaps that limit fitness.
View article: Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function
Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function Open
53BP1 is a chromatin-associated protein that regulates the DNA damage response. In this study, we identify the TPX2/Aurora A heterodimer, nominally considered a mitotic kinase complex, as a novel binding partner of 53BP1. We find that TPX2…
View article: Coexistence of dipolar frustration and criticality in ferromagnets
Coexistence of dipolar frustration and criticality in ferromagnets Open
In real magnets the tendency towards ferromagnetism, promoted by exchange\ncoupling, is usually frustrated by dipolar interaction. As a result, the\nuniformly ordered phase is replaced by modulated (multi-domain) phases,\ncharacterized by …
View article: Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing
Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing Open
Pds5 is required for sister chromatid cohesion, and somewhat paradoxically, to remove cohesin from chromosomes. We found that Pds5 plays a critical role during DNA replication that is distinct from its previously known functions. Loss of P…
View article: Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts
Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts Open
In a lifetime, a human being synthesizes approximately 2×10 16 meters of DNA, a distance that corresponds to 130,000 times the distance between the Earth and the Sun. This daunting task is executed by thousands of replication forks, which …
View article: Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork
Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork Open
Faithful DNA replication is essential for genome stability. To ensure accurate replication, numerous complex and redundant replication and repair mechanisms function in tandem with the core replication proteins to ensure DNA replication co…
View article: Thirty per cent contrast in secondary-electron imaging by scanning field-emission microscopy
Thirty per cent contrast in secondary-electron imaging by scanning field-emission microscopy Open
We perform scanning tunnelling microscopy (STM) in a regime where primary electrons are field-emitted from the tip and excite secondary electrons out of the target—the scanning field-emission microscopy regime (SFM). In the SFM mode, a sec…
View article: Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors
Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors Open
Missense mutations in ATM kinase, a master regulator of DNA damage responses, are found in many cancers, but their impact on ATM function and implications for cancer therapy are largely unknown. Here we report that 72% of cancer-associated…
View article: Author response: Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors
Author response: Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Missense mutations in ATM kinase…
View article: Structural and biochemical characterization of an RNA/DNA binding motif in the N-terminal domain of RecQ4 helicases
Structural and biochemical characterization of an RNA/DNA binding motif in the N-terminal domain of RecQ4 helicases Open
The RecQ4 helicase belongs to the ubiquitous RecQ family but its exact role in the cell is not completely understood. In addition to the helicase domain, RecQ4 has a unique N-terminal part that is essential for viability and is constituted…
View article: Critical exponents and scaling invariance in the absence of a critical point
Critical exponents and scaling invariance in the absence of a critical point Open
The paramagnetic-to-ferromagnetic phase transition is believed to proceed through a critical point, at which power laws and scaling invariance, associated with the existence of one diverging characteristic length scale -- the so called cor…