Alessia Balestrini
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View article: Discovery of TRPA1 Antagonist <b>GDC-6599</b>: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease
Discovery of TRPA1 Antagonist <b>GDC-6599</b>: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease Open
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium ion channel highly expressed in the primary sensory neurons, functioning as a polymodal sensor for exogenous and endogenous stimuli, and has been implicated in neurop…
View article: Lung-innervating neurons expressing<i>Tmc3</i>can induce broncho-constriction and dilation with direct consequences for the respiratory cycle
Lung-innervating neurons expressing<i>Tmc3</i>can induce broncho-constriction and dilation with direct consequences for the respiratory cycle Open
Sensory neurons of the vagal ganglia (VG) innervate lungs and play a critical role in maintaining airway homeostasis. However, the specific VG neurons that innervate lungs, and the mechanisms by which these neurons sense and respond to air…
View article: Single-Cell Transcriptomic Analysis Links Nonmyelinating Schwann Cells to Proinflammatory Response in the Lung
Single-Cell Transcriptomic Analysis Links Nonmyelinating Schwann Cells to Proinflammatory Response in the Lung Open
The lung is a barrier tissue with constant exposure to the inhaled environment. Therefore, innate immunity against particulates and pathogens is of critical importance to maintain tissue homeostasis. Although the lung harbors both myelinat…
View article: Supplementary Figure S2 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplementary Figure S2 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Flow cytometric analysis of haematopoietic tissues
View article: SUPPLEMENTARY MATERIALS from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
SUPPLEMENTARY MATERIALS from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
EXTENDED EXPERIMENTAL PROCEDURES and SUPPLEMENTARY FIGURE LEGENDS
View article: Supplementary Figure S3 F from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplementary Figure S3 F from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Sμ-Sγ1 junctions
View article: Supplementary Figure S3 F from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplementary Figure S3 F from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Sμ-Sγ1 junctions
View article: SUPPLEMENTARY MATERIALS from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
SUPPLEMENTARY MATERIALS from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
EXTENDED EXPERIMENTAL PROCEDURES and SUPPLEMENTARY FIGURE LEGENDS
View article: Data from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Data from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
The Mre11 complex (Mre11, Rad50, and Nbs1) occupies a central node of the DNA damage response (DDR) network and is required for ATM activation in response to DNA damage. Hypomorphic alleles of MRE11 and NBS1 confer embryonic …
View article: Supplementary Figure S4 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplementary Figure S4 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Chromosomal instability in primary B cells and immortalized MEFs
View article: Supplemental Figure S1 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplemental Figure S1 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Nbs1deltaB/deltaB Atm -/- immortalized MEFs show inability to form colonies at atmospheric oxygen levels.
View article: Supplementary Figure S3 A-E from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplementary Figure S3 A-E from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Events upstream AID-mediated switch lesion are not affected in Nbs1deltaB/deltaB Atm -/- VAV B cells
View article: Supplementary Figure S6 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplementary Figure S6 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Immunohistochemical characterization of thymic lymphomas.
View article: Supplementary Figure S3 A-E from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplementary Figure S3 A-E from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Events upstream AID-mediated switch lesion are not affected in Nbs1deltaB/deltaB Atm -/- VAV B cells
View article: Supplementary Figure S5 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplementary Figure S5 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Increased replication stress in Nbs1deltaB/deltaB Atm -/- VAV primary cells.
View article: Supplemental Figure S1 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplemental Figure S1 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Nbs1deltaB/deltaB Atm -/- immortalized MEFs show inability to form colonies at atmospheric oxygen levels.
View article: Supplementary Figure S5 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplementary Figure S5 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Increased replication stress in Nbs1deltaB/deltaB Atm -/- VAV primary cells.
View article: Supplementary Figure S4 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplementary Figure S4 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Chromosomal instability in primary B cells and immortalized MEFs
View article: Data from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Data from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
The Mre11 complex (Mre11, Rad50, and Nbs1) occupies a central node of the DNA damage response (DDR) network and is required for ATM activation in response to DNA damage. Hypomorphic alleles of MRE11 and NBS1 confer embryonic …
View article: Supplementary Figure S6 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplementary Figure S6 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Immunohistochemical characterization of thymic lymphomas.
View article: Supplementary Figure S2 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Supplementary Figure S2 from Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
Flow cytometric analysis of haematopoietic tissues
View article: Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy Open
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a polymodal sensor for exogenous and endogenous stimuli and has generated widespr…
View article: A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment
A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment Open
Despite the development of effective therapies, a substantial proportion of asthmatics continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient receptor potential cation channel member A1 (TRPA1) agonists ar…
View article: Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma
Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma Open
View article: A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination
A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination Open
View article: Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model Open
The Mre11 complex (Mre11, Rad50, and Nbs1) occupies a central node of the DNA damage response (DDR) network and is required for ATM activation in response to DNA damage. Hypomorphic alleles of MRE11 and NBS1 confer embryonic lethality in A…