Explanipedia

Nicotinamide Mononucleotide Administration Prevents Doxorubicin-Induced Cardiotoxicity and Loss in Physical Activity in Mice Open

Marielle Margier, Chisaka Kuehnemann, Nicolas Hulo, Jazmin Morales, Prasanna Vadhana Ashok Kumaar , et al. · 2022

Doxorubicin (Doxo) is a widely used antineoplastic drug with limited clinical application due to its deleterious dose-related side effects. We investigated whether nicotinamide mononucleotide (NMN) could protect against Doxo-induced cardio…

Nicotinamide Mononucleotide Administration Triggers Macrophages Reprogramming and Alleviates Inflammation During Sepsis Induced by Experimental Peritonitis Open

Cécile Cros, Marielle Margier, Hélène Cannelle, Julie Charmetant, Nicolas Hulo , et al. · 2022

Peritonitis and subsequent sepsis lead to high morbidity and mortality in response to uncontrolled systemic inflammation primarily mediated by macrophages. Nicotinamide adenine dinucleotide (NAD+) is an important regulator of oxidative str…

Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability? Open

Andrea Benzi, Alessia Grozio, Sonia Spinelli, Laura Sturla, Andreas H. Guse , et al. · 2021

Nicotinamide adenine dinucleotide (NAD+) is a fundamental molecule in the regulation of energy metabolism, representing both a coenzyme and a substrate for different NAD+ degrading enzymes. Among these enzymes, CD38 can be seen under two p…

Safety evaluation after acute and sub-chronic oral administration of high purity nicotinamide mononucleotide (NMN-C®) in Sprague-Dawley rats Open

Cécile Cros, Hélène Cannelle, Laurent Laganier, Alessia Grozio, Matthias Canault · 2021

β-nicotinamide mononucleotide (NMN) is a natural molecule intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD⁺). Preclinical evidences point to the beneficial effect of NMN administration on several age-re…

NAD+ metabolism and its roles in cellular processes during ageing Open

Anthony J. Covarrubias, Rosalba Perrone, Alessia Grozio, Eric Verdin · 2020

Author Correction: Slc12a8 is a nicotinamide mononucleotide transporter Open

Alessia Grozio, Kathryn F. Mills, Jun Yoshino, Santina Bruzzone, Giovanna Sociali , et al. · 2019

Slc12a8 is a nicotinamide mononucleotide transporter Open

Alessia Grozio, Kathryn F. Mills, Jun Yoshino, Santina Bruzzone, Giovanna Sociali , et al. · 2018

SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells Open

Giovanna Sociali, Alessia Grozio, Irene Caffa, Susanne Schuster, Pamela Becherini , et al. · 2018

Nicotinamide phosphoribosyltransferase (NAMPT) is the rate‐limiting enzyme in the NAD + salvage pathway from nicotinamide. By controlling the biosynthesis of NAD + , NAMPT regulates the activity of NAD + ‐converting enzymes, such as CD38, …

SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects Open

Patrizia Damonte, Giovanna Sociali, Marco Parenti, Debora Soncini, Inga Bauer , et al. · 2017

Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model Open

Giovanna Sociali, Mirko Magnone, Silvia Ravera, Patrizia Damonte, Tiziana Vigliarolo , et al. · 2017

Sirtuin 6 (SIRT6) is a sirtuin family member involved in a wide range of physiologic and disease processes, including cancer and glucose homeostasis. Based on the roles played by SIRT6 in different organs, including its ability to repress …

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice Open

Kathryn F. Mills, Shohei Yoshida, Liana R. Stein, Alessia Grozio, Shunsuke Kubota , et al. · 2016

Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics Open

Giovanna Sociali, Lauretta Galeno, Marco Parenti, Alessia Grozio, Inga Bauer , et al. · 2015

Alessia Grozio YOU? Author Swipe