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View article: From 2015 to 2025: how ATA guidelines reshape nuclear medicine practice in thyroid cancer
From 2015 to 2025: how ATA guidelines reshape nuclear medicine practice in thyroid cancer Open
Purpose The American Thyroid Association (ATA) 2025 guidelines for the management of differentiated thyroid cancer (DTC) introduce significant updates for nuclear medicine physicians, focusing on a more individualized, patient-centered app…
View article: Fifty Shades of PSMA-Avid Rib Lesions: A Comprehensive Review
Fifty Shades of PSMA-Avid Rib Lesions: A Comprehensive Review Open
Background: While prostate-specific membrane antigen (PSMA)-targeted imaging has revolutionized metastatic detection, unspecific bone uptake (UBU)—particularly in the ribs—is a common but diagnostically challenging finding in prostate canc…
View article: Revealing the hidden: A systematic review and meta-analysis of FAPI-based tracers imaging for brain metastatic lesions
Revealing the hidden: A systematic review and meta-analysis of FAPI-based tracers imaging for brain metastatic lesions Open
Background Regarding the assessment of brain metastatic lesions, [ 18 F]FDG PET/CT encounters challenges due to heightened physiological uptake in normal brain tissue, resulting in poor tumor-to-background ratios (TBR). Detecting brain met…
View article: P03.03.B PREVALENCE AND SIGNIFICANCE OF INCIDENTAL PET FINDINGS IN THE BRAIN USING RADIOTRACERS OTHER THAN [18F]FDG: A META-ANALYSIS
P03.03.B PREVALENCE AND SIGNIFICANCE OF INCIDENTAL PET FINDINGS IN THE BRAIN USING RADIOTRACERS OTHER THAN [18F]FDG: A META-ANALYSIS Open
BACKGROUND Incidental brain imaging findings could be clinically relevant and advancements in molecular imaging could lead to a more frequent identification. The aim of this study is to perform a meta-analysis to establish the prevalence a…
View article: Impacto de inserciones curriculares en estudiantes de Educación General Básica, Ministerio de Educación de Ecuador, régimen Costa-Galápagos 2025-2026
Impacto de inserciones curriculares en estudiantes de Educación General Básica, Ministerio de Educación de Ecuador, régimen Costa-Galápagos 2025-2026 Open
Este estudio investiga el impacto de las inserciones curriculares en los estudiantes de Educación General Básica (EGB) dentro del régimen Ciclo Costa - Galápagos de Ecuador, durante el año escolar 2025-2026. La introducción de áreas como l…
View article: Emerging PET-radiotracers in cardiovascular, neuro-inflammation, lung and rheumatological diseases: a narrative review
Emerging PET-radiotracers in cardiovascular, neuro-inflammation, lung and rheumatological diseases: a narrative review Open
Emerging PET radiotracers showed promising results in detecting inflammatory diseases in different anatomical sites, but more robust and comprehensive studies are required for their clinical use.
View article: Efficacy and Safety of Radioligand Therapy with Actinium-225 DOTATATE in Patients with Advanced, Metastatic or Inoperable Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis
Efficacy and Safety of Radioligand Therapy with Actinium-225 DOTATATE in Patients with Advanced, Metastatic or Inoperable Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis Open
Background and Objectives: Peptide receptor radionuclide therapy (PRRT) using radiopharmaceuticals labelled with Lutetium-177 is currently a therapeutic option for patients with advanced neuroendocrine neoplasms overexpressing somatostatin…
View article: Diagnostic value of dual-tracer PET/CT with [18F]FDG and PSMA ligands in prostate cancer: an updated systematic review
Diagnostic value of dual-tracer PET/CT with [18F]FDG and PSMA ligands in prostate cancer: an updated systematic review Open
Background Prostate-specific membrane antigen (PSMA) ligand PET/CT has significantly improved prostate cancer (PCa) imaging. However, in patients with poorly differentiated PCa or neuroendocrine transdifferentiation, [ 18 F]fluorodeoxygluc…
View article: Meta-Analysis on the Prevalence and Significance of Incidental Findings in the Thyroid Gland Using Other PET Radiopharmaceuticals Beyond [18F]FDG
Meta-Analysis on the Prevalence and Significance of Incidental Findings in the Thyroid Gland Using Other PET Radiopharmaceuticals Beyond [18F]FDG Open
Background: Meta-analyses on the prevalence and significance of thyroid incidentalomas at PET (TIP) are available only about [18F]FDG. Focal TIP at [18F]FDG PET is not rare and may be malignant lesions in about one-third of cases. The aim …
View article: The Prevalence and Significance of Incidental Positron Emission Tomography Findings in the Brain Using Radiotracers Other than [18F]FDG: A Systematic Review and Meta-Analysis
The Prevalence and Significance of Incidental Positron Emission Tomography Findings in the Brain Using Radiotracers Other than [18F]FDG: A Systematic Review and Meta-Analysis Open
Background: Incidental brain imaging findings could be clinically relevant, and advancements in molecular imaging could lead to their more frequent identification. The aim of this review is to establish the prevalence and clinical signific…
View article: Impact of Metastasis-directed Therapy Guided by Different PET/CT Radiotracers on Distant and Local Disease Control in Oligorecurrent Hormone-sensitive Prostate Cancer: A Secondary Analysis of the PRECISE-MDT Study
Impact of Metastasis-directed Therapy Guided by Different PET/CT Radiotracers on Distant and Local Disease Control in Oligorecurrent Hormone-sensitive Prostate Cancer: A Secondary Analysis of the PRECISE-MDT Study Open
Metastasis-directed therapy guided by gallium 68 ( 68 Ga) prostate-specific membrane antigen (PSMA)-11 PET/CT improved metastasis-free survival but not local recurrence-free survival compared with fluorine 18 ( 18 F)-PSMA-1007 and 18 F-flu…
View article: [18F]FDG PET imaging in the differentiation of cardiac masses: an updated systematic review and dual Meta-Analysis of diagnostic performance and parameter variability
[18F]FDG PET imaging in the differentiation of cardiac masses: an updated systematic review and dual Meta-Analysis of diagnostic performance and parameter variability Open
View article: PSMA-targeted PET imaging for brain metastases from non-prostatic solid tumors: a systematic review
PSMA-targeted PET imaging for brain metastases from non-prostatic solid tumors: a systematic review Open
Introduction Prostate-Specific Membrane Antigen (PSMA) is a transmembrane glycoprotein initially identified in prostate cancer (PCa) but also expressed in the neovasculature of various solid tumors. Recently, PSMA PET has emerged as a prom…
View article: A0537 – Enhancing nomograms with PSMA PET for selecting optimal candidates for extended pelvic lymph node dissection in intermediate-risk prostate cancer patients.
A0537 – Enhancing nomograms with PSMA PET for selecting optimal candidates for extended pelvic lymph node dissection in intermediate-risk prostate cancer patients. Open
View article: [18F]Tetrafluoroborate, a new NIS PET/CT radiopharmaceutical: an overview focused on differentiated thyroid cancer
[18F]Tetrafluoroborate, a new NIS PET/CT radiopharmaceutical: an overview focused on differentiated thyroid cancer Open
Background In relapsing differentiated thyroid cancer (DTC), the in vivo evaluation of natrium–iodide symporter (NIS) expression is pivotal in the therapeutic planning and is achieved by 131/123 Iodine ( 131/123 I) whole body scan. However…
View article: Semiquantitative 2-[18F]FDG PET/CT-based parameters role in lymphoma
Semiquantitative 2-[18F]FDG PET/CT-based parameters role in lymphoma Open
2-deoxy-2-[ 18 F]-fluoro-D-glucose (2-[ 18 F]FDG) positron emission tomography/computed tomography (PET/CT) plays a crucial role in the management of lymphoma in different settings, such as staging disease, assessing response to therapy, p…
View article: O10 Guiding metastasis-directed therapy with different PET/CT radiotracers affects distant but not local disease control in oligorecurrent hormone-sensitive prostate cancer patients: a secondary analysis of the PRECISE-MDT Study
O10 Guiding metastasis-directed therapy with different PET/CT radiotracers affects distant but not local disease control in oligorecurrent hormone-sensitive prostate cancer patients: a secondary analysis of the PRECISE-MDT Study Open
View article: Diagnostic Performance of Prostate-Specific Membrane Antigen-Targeted Positron Emission Tomography in Patients Diagnosed with Different Types of Breast Cancer: A Systematic Review
Diagnostic Performance of Prostate-Specific Membrane Antigen-Targeted Positron Emission Tomography in Patients Diagnosed with Different Types of Breast Cancer: A Systematic Review Open
Recent research has proposed using positron emission tomography/computed tomography (PET/CT) along with the administration of prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals to identify breast cancer (BC) lesions. …
View article: Detection of cardiac neuroendocrine tumour metastases by somatostatin receptor PET/CT: a systematic review and meta-analysis
Detection of cardiac neuroendocrine tumour metastases by somatostatin receptor PET/CT: a systematic review and meta-analysis Open
Background Cardiac neuroendocrine tumour metastases (CNTM) are rare, but advancements in molecular imaging including somatostatin receptor PET/CT (SSTR-PET/CT) could lead to a more frequent identification. The aim of this article is to per…
View article: Diagnostic performance of 2-[18F]FDG PET/CT in recurrent differentiated thyroid cancer and elevated antithyroglobulin antibodies: an updated systematic review and bivariate meta-analysis
Diagnostic performance of 2-[18F]FDG PET/CT in recurrent differentiated thyroid cancer and elevated antithyroglobulin antibodies: an updated systematic review and bivariate meta-analysis Open
View article: Prognostic Role of Pre- and Post-Treatment [18F]FDG PET/CT in Squamous Cell Carcinoma of the Oropharynx in Patients Treated with Chemotherapy and Radiotherapy
Prognostic Role of Pre- and Post-Treatment [18F]FDG PET/CT in Squamous Cell Carcinoma of the Oropharynx in Patients Treated with Chemotherapy and Radiotherapy Open
Background: The prognostic role of imaging with [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in oropharynx cancer (OPC) has been demonstrated in the past. The aim of this study was to assess …
View article: Performance of [18F]FDG PET/CT in Diagnosing Cyst Infections in Patients with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review and a Bivariate Meta-Analysis
Performance of [18F]FDG PET/CT in Diagnosing Cyst Infections in Patients with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review and a Bivariate Meta-Analysis Open
Background: Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) has been suggested as a useful imaging method for diagnosing cyst infections in patients with autosomal dominant polycystic kidne…
View article: The Potential Role of PSMA-Targeted PET in Salivary Gland Malignancies: An Updated Systematic Review
The Potential Role of PSMA-Targeted PET in Salivary Gland Malignancies: An Updated Systematic Review Open
Background: Recent studies have suggested using positron emission tomography/computed tomography (PET/CT) with prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals for the detection of salivary gland malignancies (SGM),…
View article: Diverse Imaging Methods May Influence Long-Term Oncologic Outcomes in Oligorecurrent Prostate Cancer Patients Treated with Metastasis-Directed Therapy (the PRECISE-MDT Study)
Diverse Imaging Methods May Influence Long-Term Oncologic Outcomes in Oligorecurrent Prostate Cancer Patients Treated with Metastasis-Directed Therapy (the PRECISE-MDT Study) Open
Metastasis-directed therapy (MDT) has been tested in clinical trials as a treatment option for oligorecurrent prostate cancer (PCa). However, there is an ongoing debate regarding the impact of using different imaging techniques interchange…
View article: The Homunculus of unspecific bone uptakes associated with PSMA-targeted tracers: a systematic review-based definition
The Homunculus of unspecific bone uptakes associated with PSMA-targeted tracers: a systematic review-based definition Open
Purpose Prostate-Specific Membrane Antigen (PSMA)-targeted Positron Emission Tomography (PET) has revolutionised prostate cancer (PCa) diagnosis and treatment, offering superior diagnostic accuracy over traditional methods and enabling the…
View article: The Role of Fibroblast Activation Protein Inhibitor Positron Emission Tomography in Inflammatory and Infectious Diseases: An Updated Systematic Review
The Role of Fibroblast Activation Protein Inhibitor Positron Emission Tomography in Inflammatory and Infectious Diseases: An Updated Systematic Review Open
The role of fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) is emerging for the assessment of non-oncological diseases, such as inflammatory and infectious diseases, even if the evid…
View article: The Clinical Role of CXCR4-Targeted PET on Lymphoproliferative Disorders: A Systematic Review
The Clinical Role of CXCR4-Targeted PET on Lymphoproliferative Disorders: A Systematic Review Open
Background/Objectives: We conducted a comprehensive investigation to explore the pathological expression of the CXCR4 receptor in lymphoproliferative disorders (LPDs) using [68Ga]Ga-Pentixafor PET/CT or PET/MRI technology. The PICO questio…
View article: The Diagnostic Performance of 2-[18F]FDG PET/CT in Identifying Richter Transformation in Chronic Lymphocytic Leukemia: An Updated Systematic Review and Bivariate Meta-Analysis
The Diagnostic Performance of 2-[18F]FDG PET/CT in Identifying Richter Transformation in Chronic Lymphocytic Leukemia: An Updated Systematic Review and Bivariate Meta-Analysis Open
Richter transformation is a rare phenomenon characterized by the transformation of cell chronic lymphocytic leukemia (CLL) into a more aggressive lymphoma variant. The early identification of CLLs with a high risk of RT is fundamental. In …
View article: Diagnostic yield of FAP-guided positron emission tomography in thyroid cancer: a systematic review
Diagnostic yield of FAP-guided positron emission tomography in thyroid cancer: a systematic review Open
Background Several recent studies have proposed the possible application of positron emission tomography/computed tomography (PET/CT) administering radiolabelled fibroblast-activation protein (FAP) inhibitors for various forms of thyroid c…
View article: Expanding the clinical indications of [18F]fluorocholine PET/CT in primary hyperparathyroidism: the evidence cannot be evaded
Expanding the clinical indications of [18F]fluorocholine PET/CT in primary hyperparathyroidism: the evidence cannot be evaded Open