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View article: Effectiveness of ICI-ICI versus ICI-TKI combinations in patients with IMDC intermediate- and poor-risk metastatic renal cell carcinoma: a sub-analysis of the MEET-URO 33 study
Effectiveness of ICI-ICI versus ICI-TKI combinations in patients with IMDC intermediate- and poor-risk metastatic renal cell carcinoma: a sub-analysis of the MEET-URO 33 study Open
Background Immune checkpoint inhibitor doublet (ICI–ICI) and ICI plus tyrosine kinase inhibitor (ICI–TKI) regimens are the cornerstone of treatment for metastatic renal cell carcinoma (mRCC), although no head-to-head comparisons are curren…
View article: Cefiderocol therapy among immunocompromised adult patients: a descriptive analysis from a prospective, multicentre cohort study
Cefiderocol therapy among immunocompromised adult patients: a descriptive analysis from a prospective, multicentre cohort study Open
View article: Meet-URO Score Validation in Real-world Patients with Metastatic Renal Cell Carcinoma Receiving First-line Pembrolizumab Plus axitinib
Meet-URO Score Validation in Real-world Patients with Metastatic Renal Cell Carcinoma Receiving First-line Pembrolizumab Plus axitinib Open
The Meet-URO score provided a more accurate prognostication than the international metastatic RCC database consortium (IMDC) risk group classification for patients with metastatic renal cell carcinoma (mRCC) by incorporating the pretreatme…
View article: From Klebsiella and Candida to artificial intelligence: a perspective from infectious diseases doctors and researchers
From Klebsiella and Candida to artificial intelligence: a perspective from infectious diseases doctors and researchers Open
The advent of artificial intelligence (AI) and machine learning (ML) is progressively influencing clinical reasoning in infectious diseases, particularly in the management of septic shock where timely empirical antimicrobial therapy is cru…
View article: Use of a molecular syndromic panel for the etiological diagnosis of ventilator-associated bacterial pneumonia: impact on clinical outcomes and antibiotic use from a multicenter, prospective study
Use of a molecular syndromic panel for the etiological diagnosis of ventilator-associated bacterial pneumonia: impact on clinical outcomes and antibiotic use from a multicenter, prospective study Open
View article: Abuse in Individuals with Multiple Sclerosis: The SocialMS Italian Study
Abuse in Individuals with Multiple Sclerosis: The SocialMS Italian Study Open
Introduction: Abuse is a social determinant of health (SDH) which consists in behaviors used to gain or maintain power and control, including physical, sexual, financial, emotional or psychological actions [1]. In general, individuals with…
View article: Use of isavuconazole in critically ill patients in intensive care units: a prospective, observational, multicentre, cohort study
Use of isavuconazole in critically ill patients in intensive care units: a prospective, observational, multicentre, cohort study Open
Objectives In this multicentre, prospective study, we aimed to describe the use of isavuconazole in critically ill adult patients in ICU, in terms of patient characteristics, infection characteristics and outcomes. Methods Prospective, obs…
View article: Evaluating Treatment Efficacy in Metastatic Hormone-sensitive Prostate Cancer Patients with Visceral Disease: A Systematic Review and Network Meta-analysis
Evaluating Treatment Efficacy in Metastatic Hormone-sensitive Prostate Cancer Patients with Visceral Disease: A Systematic Review and Network Meta-analysis Open
Treatment intensification with triplet therapy (ADT + docetaxel + darolutamide) provides the greatest OS benefit in mHSPC patients with VD. Doublet regimens incorporating chemotherapy or abiraterone remain viable alternatives. Further pros…
View article: Deep Learning for the Early Diagnosis of Candidemia
Deep Learning for the Early Diagnosis of Candidemia Open
View article: Mortality of <i>Pneumocystis jirovecii</i> pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG
Mortality of <i>Pneumocystis jirovecii</i> pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG Open
PJP mortality remains high in ICU patients. Conditions other than HIV infection are emerging not only as non-classical risk factors for PJP development, but also as important mortality predictors. A better understanding of the reasons unde…
View article: Safety assessment of switching from fingolimod to siponimod: An Italian multicenter prospective study
Safety assessment of switching from fingolimod to siponimod: An Italian multicenter prospective study Open
During the 6-month observation period, switching from fingolimod to siponimod was safe in terms of disease reactivation and tolerability.
View article: Polycyclic aromatic hydrocarbons skin exposure among coke workers and skin cancer correlation: local data bank and case study
Polycyclic aromatic hydrocarbons skin exposure among coke workers and skin cancer correlation: local data bank and case study Open
Polycyclic aromatic hydrocarbons (PAHs) are a group of persistent environmental pollutants, recognized as carcinogens to the human body and associated with increased cancer risk, particularly in occupationally exposed workers. This study a…
View article: Validation of the Italian Version of the Rapid Geriatric Assessment in Community-Dwelling Older Adults
Validation of the Italian Version of the Rapid Geriatric Assessment in Community-Dwelling Older Adults Open
Background/Objectives: The Rapid Geriatric Assessment (RGA) is a tool designed to screen for frailty, sarcopenia, anorexia related to aging, and cognitive impairment. This study aimed to translate and validate the RGA for use among Italian…
View article: A0537 – Enhancing nomograms with PSMA PET for selecting optimal candidates for extended pelvic lymph node dissection in intermediate-risk prostate cancer patients.
A0537 – Enhancing nomograms with PSMA PET for selecting optimal candidates for extended pelvic lymph node dissection in intermediate-risk prostate cancer patients. Open
View article: Advantages and limitations of large language models for antibiotic prescribing and antimicrobial stewardship
Advantages and limitations of large language models for antibiotic prescribing and antimicrobial stewardship Open
View article: Prognostic Frailty-Based Determinants of Long-Term Mortality in Older Patients with Newly Diagnosed Multiple Myeloma
Prognostic Frailty-Based Determinants of Long-Term Mortality in Older Patients with Newly Diagnosed Multiple Myeloma Open
Background/Objectives: Multiple myeloma (MM) is a plasma cell neoplasm predominantly diagnosed in older adults. However, the significance of defining patient frailty, as well as identifying the most suitable and reliable tools for its asse…
View article: Prognostic Value of G8 Geriatric Screening and Meet-URO Scores in Metastatic Renal Cell Carcinoma Patients Receiving First-Line Ipilimumab-Nivolumab Combination Immunotherapy
Prognostic Value of G8 Geriatric Screening and Meet-URO Scores in Metastatic Renal Cell Carcinoma Patients Receiving First-Line Ipilimumab-Nivolumab Combination Immunotherapy Open
Background The prognostic value of the Geriatric 8 (G8) screening score in metastatic renal cell carcinoma (mRCC) patients receiving first-line immunotherapy remains unclear. This study aimed to evaluate the prognostic role of G8 within th…
View article: Antibiotics and Artificial Intelligence: Clinical Considerations on a Rapidly Evolving Landscape
Antibiotics and Artificial Intelligence: Clinical Considerations on a Rapidly Evolving Landscape Open
The growing interest in leveraging artificial intelligence (AI) tools for healthcare decision-making extends to improving antibiotic prescribing. Large language models (LLMs), a type of AI trained on extensive datasets from diverse sources…
View article: P-1032. Posaconazole for Prevention of COVID-19 Associated Pulmonary Aspergillosis in Mechanically Ventilated Patients: the POSACOVID Study
P-1032. Posaconazole for Prevention of COVID-19 Associated Pulmonary Aspergillosis in Mechanically Ventilated Patients: the POSACOVID Study Open
Background The relative number of COVID-19 patients developing COVID-19 associated pulmonary aspergillosis (CAPA) has been increasing within the vaccination area and mortality is still high. This study investigated the impact of posaconazo…
View article: Posaconazole for Prevention of <scp>COVID</scp>‐19‐Associated Pulmonary Aspergillosis in Mechanically Ventilated Patients: A European Multicentre Case–Control Study (<scp>POSACOVID</scp>)
Posaconazole for Prevention of <span>COVID</span>‐19‐Associated Pulmonary Aspergillosis in Mechanically Ventilated Patients: A European Multicentre Case–Control Study (<span>POSACOVID</span>) Open
Background This study investigated the impact of posaconazole (POSA) prophylaxis in COVID‐19 patients with acute respiratory failure receiving systemic corticosteroids on the risk for the development of COVID‐19‐associated pulmonary asperg…
View article: Uncovering a Bias in Estimated Treatment Effects on PIRA in Multiple Sclerosis Clinical Trials
Uncovering a Bias in Estimated Treatment Effects on PIRA in Multiple Sclerosis Clinical Trials Open
View article: Meet-URO Score Validation in Real-world Patients with Metastatic Renal Cell Carcinoma Receiving First-line Pembrolizumab Plus axitinib: A Subanalysis of the Prospective ProPAXI Study.
Meet-URO Score Validation in Real-world Patients with Metastatic Renal Cell Carcinoma Receiving First-line Pembrolizumab Plus axitinib: A Subanalysis of the Prospective ProPAXI Study. Open
The Meet-URO score provided a more accurate prognostication than the international metastatic RCC database consortium (IMDC) risk group classification for patients with metastatic renal cell carcinoma (mRCC) by incorporating the pretreatme…
View article: Disease-modifying treatment and disability progression in subclasses of patients with primary progressive MS: results from the Big MS Data Network
Disease-modifying treatment and disability progression in subclasses of patients with primary progressive MS: results from the Big MS Data Network Open
Background Effectiveness of disease-modifying treatment (DMT) in people affected by primary progressive multiple sclerosis (PPMS) is limited. Whether specific subgroups may benefit more from DMT in a real-world setting remains unclear. Our…
View article: Clinical and biological underpinnings of longitudinal atrophy pattern progression in Alzheimer's disease
Clinical and biological underpinnings of longitudinal atrophy pattern progression in Alzheimer's disease Open
Background Magnetic resonance imaging (MRI) has recently enabled to identify four distinct Alzheimer's disease (AD) subtypes: hippocampal sparing (HpSp), typical AD (tAD), limbic predominant (Lp), and minimal atrophy (MinAtr). To date, how…
View article: Efficacy of favipiravir in COVID-19: A retrospective two center comparative study
Efficacy of favipiravir in COVID-19: A retrospective two center comparative study Open
Introduction: Favipiravir (FVP) is an antiviral, targeting RNA-dependent RNA polymerase. We aimed to evaluate the efficacy of FVP as a treatment for COVID-19. Methods: We conducted a retrospective study in two centers (San Martino Universi…
View article: Synthetic data in Multiple Sclerosis: replicating the results of a clinical trial with artificially generated data.
Synthetic data in Multiple Sclerosis: replicating the results of a clinical trial with artificially generated data. Open
Background Collecting high quality, patient level data demands significant efforts and resources. A potential solution, well-suited for exploratory hypothesis testing, gathering evidence, and assessing the heterogeneity and generalizabilit…
View article: Composite Prediction Score to Interpret Bone Focal Uptake in Hormone-Sensitive Prostate Cancer Patients Imaged with [<sup>18</sup>F]PSMA-1007 PET/CT
Composite Prediction Score to Interpret Bone Focal Uptake in Hormone-Sensitive Prostate Cancer Patients Imaged with [<sup>18</sup>F]PSMA-1007 PET/CT Open
Unspecific bone uptake (UBU) related to [18F]PSMA-1007 PET/CT imaging represents a clinical challenge. We aimed to assess whether a combination of clinical, biochemical, and imaging parameters could predict skeletal metastases i…
View article: Prognostic frailty-based determinants of long-term mortality in older patients with newly diagnosed multiple myeloma
Prognostic frailty-based determinants of long-term mortality in older patients with newly diagnosed multiple myeloma Open
Introduction Multiple myeloma (MM) is a plasma cell neoplasm predominantly diagnosed in older adults. However, the significance of defining patient frailty, as well as identifying the most suitable and reliable tools for its assessment, re…
View article: Prognostic value of type of prior TKI in pretreated metastatic renal cell carcinoma patients receiving nivolumab
Prognostic value of type of prior TKI in pretreated metastatic renal cell carcinoma patients receiving nivolumab Open
Aim: To define the prognostic significance of first-line TKI in mRCC patients receiving nivolumab.Materials and methods: A total of 571 mRCC patients who received ≥second line nivolumab were included in this subanalysis. The …
View article: Artificial intelligence and prescription of antibiotic therapy: present and future
Artificial intelligence and prescription of antibiotic therapy: present and future Open
Prescribing antibiotics is a complex process involving various dynamic phases. In each of these phases, the support of ML-CDSSs has shown the potential, and also the actual ability in some studies, to favorably impacting relevant clinical …