Aletta M. E. Millen
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View article: Deaths from suspected mothball poisoning in children
Deaths from suspected mothball poisoning in children Open
Childhood poisoning is a significant health concern in South Africa (SA), especially in densely populated informal housing settlements where children are frequently exposed to various household poisons. Poisoning accounts for 4 - 5% of pae…
View article: MON-581 Predictive Models For New-onset Diabetes Mellitus In Covid-19: Evaluating Insulin Resistance And Inflammation
MON-581 Predictive Models For New-onset Diabetes Mellitus In Covid-19: Evaluating Insulin Resistance And Inflammation Open
Disclosure: F. Mohamed: None. S. Gunter: None. B.E. Yirdaw: None. F.J. Raal: None. A.M. Millen: None. I.S. Kalla: None. Background: The association between COVID-19 and new-onset diabetes (DM) is primarily based on retrospective studies, w…
View article: SAT-255 Metabolic Implications Of Covid-19: Exploring Lipids And Inflammation
SAT-255 Metabolic Implications Of Covid-19: Exploring Lipids And Inflammation Open
Disclosure: F. Mohamed: None. S. Gunter: None. S. Currin: None. F.J. Raal: None. I.S. Kalla: None. A.M. Millen: None. Background: COVID-19 is associated with cardiometabolic complications, but its effect on lipoprotein(a) [Lp(a)] remains u…
View article: Potential Region-Specific Neuroprotective Effects of Kynurenine Administration in Healthy Rodents Using High-Resolution Mass Spectrometry
Potential Region-Specific Neuroprotective Effects of Kynurenine Administration in Healthy Rodents Using High-Resolution Mass Spectrometry Open
The tryptophan (TRP) metabolic pathway produces kynurenine (KYN) and serotonin (5-HT). These are important molecules in the central nervous system, as KYN plays a crucial role in neuroprotection, while 5-HT impacts mood and sleep patterns.…
View article: Metabolic Implications of COVID-19: Exploring Lipids and Inflammation
Metabolic Implications of COVID-19: Exploring Lipids and Inflammation Open
COVID-19 is associated with cardiometabolic complications, including lipid abnormalities, but its effect on lipoprotein(a) [Lp(a)] remains unclear. This study evaluated the relationship between lipid profiles, Lp(a), disease severity, and …
View article: Involvement of microRNA-146a-5p, but not -155-5p and -29b-5p, in left ventricular remodeling and dysfunction in spontaneously hypertensive rats
Involvement of microRNA-146a-5p, but not -155-5p and -29b-5p, in left ventricular remodeling and dysfunction in spontaneously hypertensive rats Open
We investigated roles of microRNAs-146a-5p, -155-5p, and -29b-5p in development of cardiac hypertrophy and dysfunction in SHRs. We showed that miR-146a-5p expression was upregulated in SHRs and positively associated with indices of concent…
View article: Decreased blood pressure with acute administration of quercetin in L‐NAME‐induced hypertensive rats
Decreased blood pressure with acute administration of quercetin in L‐NAME‐induced hypertensive rats Open
Quercetin is known to reduce blood pressure (BP); however, its acute effects are unclear. We investigated the acute effects of quercetin on BP, aortic mechanical properties and vascular reactivity in female Sprague–Dawley (SD) rats. Hypert…
View article: Evaluating the CURB-65 score for in-hospital mortality prediction in COVID-19 patients: insights into dysglycaemia
Evaluating the CURB-65 score for in-hospital mortality prediction in COVID-19 patients: insights into dysglycaemia Open
Introduction While the CURB-65 score predicts mortality in community-acquired pneumonia (CAP), its performance in COVID-19 CAP is suboptimal. Hyperglycaemia correlates with an increased mortality in COVID-19. This analysis aims to enhance …
View article: MON-300 Enhancing the CURB-65 Score for In-Hospital Mortality Prediction in COVID-19: A Glucocentric Modeling Approach
MON-300 Enhancing the CURB-65 Score for In-Hospital Mortality Prediction in COVID-19: A Glucocentric Modeling Approach Open
F. Mohamed: None. Introduction: A bidirectional relationship between COVID-19 and diabetes mellitus (DM) has been described. While the CURB-65 score has traditionally been utilized to predict mortality in cases of community-acquired pneumo…
View article: Regional Changes in Brain Biomolecular Markers in a Collagen-Induced Arthritis Rat Model
Regional Changes in Brain Biomolecular Markers in a Collagen-Induced Arthritis Rat Model Open
Background: The effects of collagen-induced arthritis (CIA), a model of systemic inflammation, on brain regional molecular markers associated with neurological disorders are uncertain. Objective: This study investigated the brain regional …
View article: High Resolution Mass Spectrometry of Cystine-Containing Neuropeptides in Histological Sections of Human FFPE Tissue Banks
High Resolution Mass Spectrometry of Cystine-Containing Neuropeptides in Histological Sections of Human FFPE Tissue Banks Open
Using our earlier developed protocol, mass spectrometry imaging of small endogenous peptides (and a selection of small metabolites) can be successfully performed directly in tissue sections of formaldehyde-fixed paraffin-embedded (FFPE) sa…
View article: The effect of TNF-α inhibitor treatment on microRNAs and endothelial function in collagen induced arthritis
The effect of TNF-α inhibitor treatment on microRNAs and endothelial function in collagen induced arthritis Open
Chronic inflammation causes dysregulated expression of microRNAs. Aberrant microRNA expression is associated with endothelial dysfunction. In this study we determined whether TNF-α inhibition impacted the expression of miRNA-146a-5p and mi…
View article: Financial literacy in South African healthcare professionals: An unmet need in health professions education
Financial literacy in South African healthcare professionals: An unmet need in health professions education Open
The holistic training of healthcare professionals as a strategy to build the healthcare system has received considerable attention. As part of training a holistic workforce, it is expected the healthcare professionals be component in manag…
View article: Inflammation‐induced left ventricular fibrosis is partially mediated by tumor necrosis factor‐α
Inflammation‐induced left ventricular fibrosis is partially mediated by tumor necrosis factor‐α Open
Chronic systemic inflammation induces fibrosis and dysregulated LV extracellular matrix remodeling by increasing local cardiac pro-fibrotic gene expression, which is partially mediated by TNF-α. Inflammation-induced LV diastolic dysfunctio…
View article: Associations of inflammatory markers with impaired left ventricular diastolic and systolic function in collagen-induced arthritis
Associations of inflammatory markers with impaired left ventricular diastolic and systolic function in collagen-induced arthritis Open
High-grade inflammation is associated with impaired LV diastolic function and greater myocardial deformation independent of haemodynamic load in CIA rats.
View article: The effect of home-based low-volume, high-intensity interval training on cardiorespiratory fitness, body composition and cardiometabolic health in women of normal body mass and those with overweight or obesity: protocol for a randomized controlled trial
The effect of home-based low-volume, high-intensity interval training on cardiorespiratory fitness, body composition and cardiometabolic health in women of normal body mass and those with overweight or obesity: protocol for a randomized controlled trial Open
Background There is a high prevalence of women in South Africa with overweight and obesity which is associated with an increased risk of cardiometabolic disorders. Perceived barriers such as lack of time and motivation reduce engagement in…
View article: Supplemental Table 2
Supplemental Table 2 Open
Short- axis systolic segmental velocity and displacement in the CIA and control groups
View article: Supplemental Tables 1 and 2
Supplemental Tables 1 and 2 Open
Supplemental data: Inflammation induced changes in left ventricular diastolic and systolic function in collagen-induced arthritis
View article: Supplemental Table 1
Supplemental Table 1 Open
Short- axis systolic segmental strain and strain rate in the CIA and control groups.
View article: Supplemental Table 1
Supplemental Table 1 Open
Supplemental data: Inflammation induced changes in left ventricular diastolic and systolic function in collagen-induced arthritis