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View article: Morphological and Molecular Distinctions of Parallel Processing Streams Reveal Two Koniocellular Pathways in the Tree Shrew DLGN
Morphological and Molecular Distinctions of Parallel Processing Streams Reveal Two Koniocellular Pathways in the Tree Shrew DLGN Open
In the mammalian visual system, three functionally distinct parallel processing streams extend from the retina to the visual thalamus and then to the visual cortex: magnocellular (M), parvocellular (P), and koniocellular (K). Tree shrews (…
View article: Tau Oligomerization Drives Neurodegeneration via Nuclear Membrane Invagination and Lamin B Receptor Binding in Alzheimer’s disease
Tau Oligomerization Drives Neurodegeneration via Nuclear Membrane Invagination and Lamin B Receptor Binding in Alzheimer’s disease Open
The microtubule-associated protein tau aggregates into oligomeric complexes that highly correlate with Alzheimer’s disease (AD) progression. Increasing evidence suggests that nuclear membrane disruption occurs in AD and related tauopathies…
View article: Co-Conservation of Synaptic Gene Expression and Circuitry in Collicular Neurons
Co-Conservation of Synaptic Gene Expression and Circuitry in Collicular Neurons Open
The superior colliculus (SC), a midbrain sensorimotor hub, is anatomically and functionally similar across vertebrates, but how its cell types have evolved is unclear. Using single-nucleus transcriptomics, we compared the SC’s molecular an…
View article: Mitochondrial Alterations in Alzheimer’s Disease: Insight from the 5xFAD Mouse Model
Mitochondrial Alterations in Alzheimer’s Disease: Insight from the 5xFAD Mouse Model Open
Mitochondrial dysfunction is increasingly recognized as a key factor in Alzheimer's disease (AD) pathogenesis, but the precise relationship between mitochondrial dynamics and proteinopathies in AD remains unclear. This study investigates t…
View article: Comparative In Vivo Imaging of Retinal Structures in Tree Shrews, Humans, and Mice
Comparative In Vivo Imaging of Retinal Structures in Tree Shrews, Humans, and Mice Open
Rodent models, such as mice and rats, are commonly used to examine retinal ganglion cell damage in eye diseases. However, as nocturnal animals, rodent retinal structures differ from primates, imposing significant limitations in studying re…
View article: Maternal diet during early gestation influences postnatal taste activity–dependent pruning by microglia
Maternal diet during early gestation influences postnatal taste activity–dependent pruning by microglia Open
A key process in central sensory circuit development involves activity-dependent pruning of exuberant terminals. Here, we studied gustatory terminal field maturation in the postnatal mouse nucleus of the solitary tract (NST) during normal …
View article: Rapid, Activity-Dependent Intrinsic Plasticity in the Developing Zebra Finch Auditory Cortex
Rapid, Activity-Dependent Intrinsic Plasticity in the Developing Zebra Finch Auditory Cortex Open
The acoustic environment an animal experiences early in life shapes the structure and function of its auditory system. This process of experience-dependent development is thought to be primarily orchestrated by potentiation and depression …
View article: Father’s care uniquely influences male neurodevelopment
Father’s care uniquely influences male neurodevelopment Open
Mammalian infants depend on parental care for survival, with numerous consequences for their behavioral development. We investigated the epigenetic and neurodevelopmental mechanisms mediating the impact of early biparental care on developm…
View article: Visible-Light Optical Coherence Tomography Fibergraphy of the Tree Shrew Retinal Ganglion Cell Axon Bundles
Visible-Light Optical Coherence Tomography Fibergraphy of the Tree Shrew Retinal Ganglion Cell Axon Bundles Open
We seek to develop techniques for high-resolution imaging of the tree shrew retina for visualizing and parameterizing retinal ganglion cell (RGC) axon bundles in vivo. We applied visible-light optical coherence tomography fibergraphy (vis-…
View article: 3D electron microscopy and volume-based bouton sorting reveal the selectivity of inputs onto geniculate relay cell and interneuron dendrite segments
3D electron microscopy and volume-based bouton sorting reveal the selectivity of inputs onto geniculate relay cell and interneuron dendrite segments Open
Introduction The visual signals evoked at the retinal ganglion cells are modified and modulated by various synaptic inputs that impinge on lateral geniculate nucleus cells before they are sent to the cortex. The selectivity of geniculate i…
View article: Rapid, activity-dependent intrinsic plasticity in the developing zebra finch auditory cortex
Rapid, activity-dependent intrinsic plasticity in the developing zebra finch auditory cortex Open
The acoustic environment an animal experiences early in life shapes the structure and function of its auditory system. This process of experience-dependent development is thought to be primarily orchestrated by potentiation and depression …
View article: Immunocytochemical and ultrastructural organization of the taste thalamus of the tree shrew (<scp><i>Tupaia belangeri</i></scp>)
Immunocytochemical and ultrastructural organization of the taste thalamus of the tree shrew (<span><i>Tupaia belangeri</i></span>) Open
Ventroposterior medialis parvocellularis (VPMP) nucleus of the primate thalamus receives direct input from the nucleus of the solitary tract, whereas the homologous thalamic structure in the rodent does not. To reveal whether the synaptic …
View article: Cortical Presynaptic Boutons Progressively Engulf Spinules as They Mature
Cortical Presynaptic Boutons Progressively Engulf Spinules as They Mature Open
Despite decades of discussion in the neuroanatomical literature, the role of the synaptic “spinule” in synaptic development and function remains elusive. Canonically, spinules are finger-like projections that emerge from postsynaptic spine…
View article: Cortical Presynaptic Boutons Progressively Engulf Spinules As They Mature
Cortical Presynaptic Boutons Progressively Engulf Spinules As They Mature Open
Despite decades of discussion in the neuroanatomical literature, the role of the synaptic ‘spinule’ in synaptic development and function remains elusive. Canonically, spinules are finger-like projections that emerge from postsynaptic spine…
View article: Exercise during abstinence normalizes ultrastructural synaptic plasticity associated with nicotine‐seeking following extended access self‐administration
Exercise during abstinence normalizes ultrastructural synaptic plasticity associated with nicotine‐seeking following extended access self‐administration Open
Nicotine‐craving progressively increases, or incubates, over abstinence following extended access self‐administration. While not yet examined for nicotine, the incubation of cocaine‐seeking is accompanied by changes in synaptic plasticity …
View article: Dataset for: Exercise during Abstinence Normalizes Ultrastructural Synaptic Plasticity Associated with Nicotine-Seeking following Extended Access Self-Administration
Dataset for: Exercise during Abstinence Normalizes Ultrastructural Synaptic Plasticity Associated with Nicotine-Seeking following Extended Access Self-Administration Open
Nicotine-craving progressively increases, or incubates, over abstinence following extended access self-administration. While not yet examined for nicotine, the incubation of cocaine-seeking is accompanied by changes in synaptic plasticity …
View article: Experience-Dependent Synaptic Plasticity in V1 Occurs without Microglial CX3CR1
Experience-Dependent Synaptic Plasticity in V1 Occurs without Microglial CX3CR1 Open
Brief monocular deprivation (MD) shifts ocular dominance and reduces the density of thalamic synapses in layer 4 of the mouse primary visual cortex (V1). We found that microglial lysosome content is also increased as a result of MD. Previo…
View article: Functional TASK-3–Like Channels in Mitochondria of Aldosterone-Producing Zona Glomerulosa Cells
Functional TASK-3–Like Channels in Mitochondria of Aldosterone-Producing Zona Glomerulosa Cells Open
Ca 2+ drives aldosterone synthesis in the cytosolic and mitochondrial compartments of the adrenal zona glomerulosa cell. Membrane potential across each of these compartments regulates the amplitude of the Ca 2+ signal; yet, only plasma mem…
View article: Transmission electron microscopy of zebrafish spinal motor nerve roots
Transmission electron microscopy of zebrafish spinal motor nerve roots Open
Background : Spinal motor nerves are essential for relaying information between the central and peripheral nervous systems. Perturbations to cell types that comprise these nerves may impair rapid and efficient transmission of action potent…
View article: Oral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model
Oral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model Open
Reducing amyloid-β (Aβ) accumulation is a promising strategy for developing Alzheimer's Disease (AD) therapeutics. We recently reported that a triphenylmethane food dye analog, Brilliant Blue G (BBG), is a dose-dependent modulator of in vi…