Alex C. Bender
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View article: Development and Characterization of pFluor50, a Fluorogenic-Based Kinetic Assay System for High-Throughput Inhibition Screening and Characterization of Time-Dependent Inhibition and Inhibition Type for Six Human CYPs
Development and Characterization of pFluor50, a Fluorogenic-Based Kinetic Assay System for High-Throughput Inhibition Screening and Characterization of Time-Dependent Inhibition and Inhibition Type for Six Human CYPs Open
Cytochrome P450s (CYPs) play an integral role in drug and xenobiotic metabolism in humans, and thus, understanding CYP inhibition and/or activation by new therapeutic candidates is an important step in the drug development process. Ideally…
View article: Association of sleep network functional connectivity with hyperexcitability and cognition in Alzheimer’s disease
Association of sleep network functional connectivity with hyperexcitability and cognition in Alzheimer’s disease Open
Background Sleep disturbances are common in Alzheimer's disease (AD) and occur at early stages. Hyperexcitability also arises during sleep and can lead to epileptiform activity and seizures that impact memory consolidation. The underlying …
View article: Sleep functional connectivity, hyperexcitability, and cognition in Alzheimer's disease
Sleep functional connectivity, hyperexcitability, and cognition in Alzheimer's disease Open
INTRODUCTION Sleep disturbances are common in Alzheimer's disease (AD) and may reflect pathologic changes in brain networks. To date, no studies have examined changes in sleep functional connectivity (FC) in AD or their relationship with n…
View article: EEG network functional connectivity during sleep and in presence of network hyperexcitability in Alzheimer’s disease
EEG network functional connectivity during sleep and in presence of network hyperexcitability in Alzheimer’s disease Open
Background Functional connectivity (FC) studies in Alzheimer’s disease (AD) have focused primarily on the awake resting state. Yet, sleep disturbances in AD are common and occur early in the disease. Network hyperexcitability in AD also ar…
View article: Altered Sleep Microarchitecture and Cognitive Impairment in Patients With Temporal Lobe Epilepsy
Altered Sleep Microarchitecture and Cognitive Impairment in Patients With Temporal Lobe Epilepsy Open
There is a fundamental alteration of sleep microarchitecture in TLE, characterized by a reduction in spindle density and spindle-SO coupling, and these changes may contribute to neurocognitive comorbidity in this disorder.
View article: Development and characterization of pFluor50, a fluorogenic-based kinetic assay system for high-throughput inhibition screening and characterization of time-dependent inhibition and inhibition type for six human CYPs
Development and characterization of pFluor50, a fluorogenic-based kinetic assay system for high-throughput inhibition screening and characterization of time-dependent inhibition and inhibition type for six human CYPs Open
1 Abstract Cytochrome P450 enzymes (CYPs) play an integral role in drug and xenobiotic metabolism in humans and thus understanding CYP inhibition or activation by new therapeutic candidates is an important step in the drug development proc…
View article: Estimating Effectiveness of Identifying Human Trafficking via Data Envelopment Analysis
Estimating Effectiveness of Identifying Human Trafficking via Data Envelopment Analysis Open
Transit monitoring is a preventative approach used to identify possible cases of human trafficking prior to exploitation while an individual is in transit or before one crosses a border. Transit monitoring is often conducted by non-governm…
View article: Focal Dorsal Hippocampal Nav1.1 Knock Down Alters Place Cell Temporal Coordination and Spatial Behavior
Focal Dorsal Hippocampal Nav1.1 Knock Down Alters Place Cell Temporal Coordination and Spatial Behavior Open
Alterations in the voltage-gated sodium channel Nav.1.1 are implicated in various neurological disorders, including epilepsy, Alzheimer’s disease, and autism spectrum disorders. Previous studies suggest that the reduction of Nav1.1 express…
View article: Executive function, episodic memory, and Medicare expenditures
Executive function, episodic memory, and Medicare expenditures Open
Introduction We examined the relationship between health care expenditures and cognition, focusing on differences across cognitive systems defined by global cognition, executive function, or episodic memory. Methods We used linear regressi…
View article: P2‐435: Executive Function, Episodic Memory and Medicare Expenditures
P2‐435: Executive Function, Episodic Memory and Medicare Expenditures Open
Medicare spending for patients with dementia is estimated at $11 billion annually, in large part due to high hospitalization rates. Understanding why impaired cognition increases hospitalization and costs can inform interventions. The obje…
View article: Cognitive Deficits Associated with Nav1.1 Alterations: Involvement of Neuronal Firing Dynamics and Oscillations
Cognitive Deficits Associated with Nav1.1 Alterations: Involvement of Neuronal Firing Dynamics and Oscillations Open
Brain oscillations play a critical role in information processing and may, therefore, be essential to uncovering the mechanisms of cognitive impairment in neurological disease. In Dravet syndrome (DS), a mutation in SCN1A, coding for the v…