Alex C. Kong
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View article: Mass drug administration trials of azithromycin: an analysis to inform future research and guidelines
Mass drug administration trials of azithromycin: an analysis to inform future research and guidelines Open
Background In 2020, the World Health Organization published a guideline on the use of mass drug administration (MDA) of the broad-spectrum antibiotic azithromycin to reduce childhood mortality. As MDA-azithromycin to reduce mortality is co…
View article: Individual and Population Level Uncertainty Interact to Determine the Performance of Outbreak Surveillance Systems
Individual and Population Level Uncertainty Interact to Determine the Performance of Outbreak Surveillance Systems Open
Background Outbreak detection frequently relies on imperfect individual-level case diagnosis. Both outbreaks and cases are discrete events that can be misclassified and uncertainty at the case level may impact the performance of outbreak a…
View article: Exploring supplemental immunization strategies to reach zero-dose children in low-and middleincome countries: a scoping review
Exploring supplemental immunization strategies to reach zero-dose children in low-and middleincome countries: a scoping review Open
View article: Challenges and Approaches to Establishing Multi-Pathogen Serosurveillance: Findings from the 2023 Serosurveillance Summit
Challenges and Approaches to Establishing Multi-Pathogen Serosurveillance: Findings from the 2023 Serosurveillance Summit Open
Multiplex-based serological surveillance is a valuable but underutilized tool to understand gaps in population-level exposure, susceptibility, and immunity to infectious diseases. Assays for which blood samples can be tested for antibodies…
View article: Challenges and approaches to establishing multi-pathogen serosurveillance: Findings from the 2023 Serosurveillance Summit
Challenges and approaches to establishing multi-pathogen serosurveillance: Findings from the 2023 Serosurveillance Summit Open
Multiplex-based serological surveillance is a valuable but underutilized tool to understand gaps in population-level exposure, susceptibility, and immunity to infectious diseases. Assays for which blood samples can be tested for antibodies…
View article: Who is missed in a community-based survey: Assessment and implications of biases due to incomplete sampling frame in a community-based serosurvey, Choma and Ndola Districts, Zambia, 2022
Who is missed in a community-based survey: Assessment and implications of biases due to incomplete sampling frame in a community-based serosurvey, Choma and Ndola Districts, Zambia, 2022 Open
Community-based serological studies are increasingly relied upon to measure disease burden, identify population immunity gaps, and guide control and elimination strategies; however, there is little understanding of the potential for and im…
View article: Ethical challenges in mass drug administration for reducing childhood mortality: a qualitative study
Ethical challenges in mass drug administration for reducing childhood mortality: a qualitative study Open
Background Mass drug administration (MDA) of medications to entire at-risk communities or populations has shown promise in the control and elimination of global infectious diseases. MDA of the broad-spectrum antibiotic azithromycin has dem…
View article: Drug‐dependent inhibition of nucleotide hydrolysis in the heterodimeric ABC multidrug transporter PatAB from <i>Streptococcus pneumoniae</i>
Drug‐dependent inhibition of nucleotide hydrolysis in the heterodimeric ABC multidrug transporter PatAB from <i>Streptococcus pneumoniae</i> Open
The bacterial heterodimeric ATP‐binding cassette (ABC) multidrug exporter PatAB has a critical role in conferring antibiotic resistance in multidrug‐resistant infections by Streptococcus pneumoniae . As with other heterodimeric ABC exporte…