Alex Dubrovskiy
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View article: Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo
Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo Open
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expres…
View article: Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo
Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo Open
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expres…
View article: Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo
Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo Open
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expres…
View article: Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma
Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) accounts for a majority of primary liver cancer and is one of the most common forms of cancer worldwide. Aberrant signaling of the FGF19-FGFR4 pathway leads to HCC in mice and is hypothesized to be a driver i…