Alex Duval YOU? Author Swipe

Last 10y

MSI expresso: a software for determining MSI status and detecting MSI-related transcription events from RNA sequencing data Open

Emmanuel Tubacher, Alexandre How‐Kit, Mourad Sahbatou, Alex Duval, Victor Renault , et al. · 2025

Summary: Microsatellite instability (MSI) is becoming increasingly important in oncology as it has been reported across more than two dozen of solid cancer types. The MSI-high phenotype has long been used as a predictive and prognostic mar…

Age-related outcomes in MSI/dMMR gastrointestinal cancers treated by immune checkpoint inhibitors and toxicity’s impact on efficacy: an immunoMSI cohort study Open

Léah Mailly-Giacchetti, Raphaël Colle, T. Samaille, Daniel Lopez-Trabada Ataz, Lilith Faucheux , et al. · 2024

Background: Immune-checkpoint inhibitors (ICIs) are the standard of care for microsatellite instability (MSI) metastatic gastrointestinal cancer (mGIC) patients in first- and later-treatment lines. We compared tolerability and efficacy of …

Prediction of response to immune checkpoint blockade in patients with metastatic colorectal cancer with microsatellite instability Open

Toky Ratovomanana, Rémy Nicolle, Romain Cohen, Adam Diehl, Aurélie Siret , et al. · 2023

Mismatch Repair Deficiency and Lynch Syndrome Among Adult Patients With Glioma Open

Patrick R. Benusiglio, Fikret Elder, Mehdi Touat, Alexandre Perrier, Marc Sanson , et al. · 2023

PURPOSE The Lynch syndrome (LS)-glioma association is poorly documented. As for mismatch repair deficiency (MMRd) in glioma, a hallmark of LS-associated tumors, there are only limited data available. We determined MMRd and LS prevalence in…

Lynch syndrome: influence of additional susceptibility variants on cancer risk Open

Roseline Vibert, Jasmine Hasnaoui, Alexandre Perrier, Alexandra Lefebvre, Chrystelle Colas , et al. · 2023

<i>BRAF</i> V600E/<i>RAS</i> Mutations and Lynch Syndrome in Patients With MSI-H/dMMR Metastatic Colorectal Cancer Treated With Immune Checkpoint Inhibitors Open

Raphaël Colle, Sara Lonardi, Marine Cachanado, Michael J. Overman, Elena Élez , et al. · 2023

Background We pooled data from 2 cohorts of immune checkpoint inhibitors-treated microsatellite instability-high/mismatch repair-deficient (MSI/dMMR) metastatic colorectal cancer patients to evaluate the prognostic value of RAS/BRAFV600E m…

Supplementary Data from Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer Open

Laëtitia Marisa, Yuna Blum, Julien Taı̈eb, Mira Ayadi, Camilla Pilati , et al. · 2023

supplementary data

Supplementary Data from Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer Open

Laëtitia Marisa, Yuna Blum, Julien Taı̈eb, Mira Ayadi, Camilla Pilati , et al. · 2023

supplementary data

Supplementary Data from Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer Open

Laëtitia Marisa, Yuna Blum, Julien Taı̈eb, Mira Ayadi, Camilla Pilati , et al. · 2023

Table S1

Data from Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer Open

Laëtitia Marisa, Yuna Blum, Julien Taı̈eb, Mira Ayadi, Camilla Pilati , et al. · 2023

Purpose:The consensus molecular subtypes (CMS) represent a significant advance in the understanding of intertumor heterogeneity in colon cancer. Intratumor heterogeneity (ITH) is the new frontier for refining prognostication and understand…

Data from Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer Open

Laëtitia Marisa, Yuna Blum, Julien Taı̈eb, Mira Ayadi, Camilla Pilati , et al. · 2023

Purpose:The consensus molecular subtypes (CMS) represent a significant advance in the understanding of intertumor heterogeneity in colon cancer. Intratumor heterogeneity (ITH) is the new frontier for refining prognostication and understand…

Supplementary Data from Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer Open

Laëtitia Marisa, Yuna Blum, Julien Taı̈eb, Mira Ayadi, Camilla Pilati , et al. · 2023

Table S1

Lynch syndrome: influence of additional susceptibility variants on cancer risk Open

Roseline Vibert, Jasmine Hasnaoui, Alexandra Lefebvre, Chrystelle Colas, Marion Dhooge , et al. · 2022

Some patients with Lynch syndrome (LS) have extreme phenotypes, i.e. cancer before the recommended screening age, or cancer for which there are no screening guidelines. We made the hypothesis that additional germline variants in cancer sus…

The Role of Immunohistochemistry Markers in Endometrial Cancer with Mismatch Repair Deficiency: A Systematic Review Open

Amélia Favier, Justine Varinot, Catherine Uzan, Alex Duval, Isabelle Brochériou , et al. · 2022

The objective of this systematic review was to summarize our current knowledge of the role of immunohistochemistry (IHC) markers for identifying mismatch repair-deficient (MMRd) tumors in endometrial cancer (EC). Identification of MMRd tum…

Consequences of the Hsp110DE9 mutation in tumorigenesis and the 5-fluorouracil-based chemotherapy response in Msh2-deficient mice Open

Kathleen Noel, A'Dem Bokhari, Romane Bertrand, Florence Renaud, Pierre Bourgoin , et al. · 2022

Prediction of Response to Immune Checkpoint Blockade in Patients with Metastatic Colorectal Cancer with Microsatellite Instability Open

Alex Duval, Toky Ratovomanana, Rémy Nicolle, Romain Cohen, Aurélien Diehl , et al. · 2022

Tumors with microsatellite instability (MSI) represent a paradigm for the success of immune checkpoint inhibitor (ICI)-based immunotherapy, particularly in patients with metastatic colorectal cancer (mCRC). To date however, tools for predi…

Pan-cancer landscape of AID-related mutations, composite mutations and its potential role in the ICI response Open

Isaias Hernández-Verdín, Kadir C. Akdemir, Daniele Ramazzotti, Giulio Caravagna, Karim Labrèche , et al. · 2021

Activation-induced cytidine deaminase, AICDA or AID, is a driver of somatic hypermutation and class-switch recombination in immunoglobulins. In addition, this deaminase belonging to the APOBEC family, may have off-target effects genome-wid…

Performance of Next-Generation Sequencing for the Detection of Microsatellite Instability in Colorectal Cancer With Deficient DNA Mismatch Repair Open

Toky Ratovomanana, Romain Cohen, Magali Svrcek, Florence Renaud, Pascale Cervera , et al. · 2021

Discordance between immunochemistry of mismatch repair proteins and molecular testing of microsatellite instability in colorectal cancer Open

Astrid Guyot d’Asnières de Salins, Gaëlle Tachon, Romain Cohen, L. Karayan-Tapon, Audelaure Junca , et al. · 2021

Immune Checkpoint Inhibition in Metastatic Colorectal Cancer Harboring Microsatellite Instability or Mismatch Repair Deficiency Open

Romain Cohen, Raphaël Colle, T. Pudlarz, Maximilien Heran, Alex Duval , et al. · 2021

Microsatellite instability (MSI) is a tumor phenotype related to a deficient DNA mismatch repair system (dMMR). This phenotype, observed in 5% of metastatic mCRC but 10–18% of localized CRC, is associated with high tumor mutational burden …

MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review Open

Amélia Favier, G Röcher, Annette K. Larsen, Romain Delangle, Catherine Uzan , et al. · 2021

The objective of this systematic review is to summarize our current knowledge on the influence of miRNAs in the epigenetic deregulation of tumor-related genes in endometrial cancer (EC). We conducted a literature search on the role of miRN…

Adrenal gland as a sanctuary site for immunotherapy in patients with microsatellite instability-high metastatic colorectal cancer Open

Romain Cohen, Vincent Jonchère, Christelle de la Fouchardière, Toky Ratovomanana, Quentin Letourneur , et al. · 2021

Metastatic colorectal cancers (mCRC) harboring microsatellite instability (MSI) are sensitive to immune checkpoint inhibitors (ICIs), but the mechanisms of resistance to ICIs remain unclear. Dissociated responses in patients with ICI-treat…

Pseudoprogression in patients treated with immune checkpoint inhibitors for microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer Open

Raphaël Colle, A. Radzik, Romain Cohen, Anna Pellat, Daniel Lopez-Tabada , et al. · 2020

Corrigendum to ‘Prognostic and predictive value of the Immunoscore in stage III colon cancer patients treated with oxaliplatin in the prospective IDEA France PRODIGE-GERCOR cohort study’ Open

Franck Pagès, Thierry André, Julien Taı̈eb, Déwi Vernerey, Julie Henriques , et al. · 2020

The authors regret that in the original publication the affiliations of Dr Svrcek were incorrectly given. The correct affiliations are as above. The authors would like to apologise for any inconvenience caused. Prognostic and predictive va…

Overcoming the challenges associated with universal screening for Lynch syndrome in colorectal and endometrial cancer Open

Patrick R. Benusiglio, Florence Coulet, Alexandra Lefebvre, Alex Duval, Grégory Nuel · 2020

Mechanisms and therapeutic implications of hypermutation in gliomas Open

Mehdi Touat, Yvonne Y. Li, Adam N. Boynton, Liam F. Spurr, J. Bryan Iorgulescu , et al. · 2020

Prognostic and predictive value of the Immunoscore in stage III colon cancer patients treated with oxaliplatin in the prospective IDEA France PRODIGE-GERCOR cohort study Open

Franck Pagès, Thierry André, Julien Taı̈eb, Déwi Vernerey, Julie Henriques , et al. · 2020

Patients atteints d’un cancer gastrique localisé MSI/dMMR, pas de chimiothérapie mais une immunothérapie périopératoire : l’essai de phase II GERCOR NEONIPIGA vient d’être ouvert au recrutement Open

Romain Cohen, T. Pudlarz, Marie‐Line Garcia‐Larnicol, Déwi Vernerey, Xavier Dray , et al. · 2020

DRES-08. CLINICAL SIGNIFICANCE OF HYPERMUTATION IN GLIOMAS Open

Mehdi Touat, Yvonne Li, Adam N. Boynton, Liam F. Spurr, Bryan Iorgulescu , et al. · 2019

BACKGROUND Hypermutation is an emerging biomarker for predicting response to immunotherapy in cancer patients, however its clinical value in gliomas is not established. We sought to assess the determinants of hypermutation in gliomas, and …

Low temperature isothermal amplification of microsatellites drastically reduces stutter artifact formation and improves microsatellite instability detection in cancer Open

Antoine Daunay, Alex Duval, Laura G. Baudrin, Olivier Buhard, Victor Renault , et al. · 2019

Microsatellites are polymorphic short tandem repeats of 1–6 nucleotides ubiquitously present in the genome that are extensively used in living organisms as genetic markers and in oncology to detect microsatellite instability (MSI). While t…

Fetching topic information...