Alex H. Mirnezami
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View article: Empty pelvis syndrome as a cause of major morbidity after pelvic exenteration: validation of a core data set
Empty pelvis syndrome as a cause of major morbidity after pelvic exenteration: validation of a core data set Open
Background Pelvic exenteration (PE) is a potentially curative treatment for advanced pelvic cancers. However, PE procedures are associated with empty pelvis syndrome (EPS), a spectrum of complications including pelvic sepsis, sinus formati…
View article: Intraoperative electron radiotherapy (IOERT) in colorectal cancer: Updated systematic review of techniques, oncological outcomes and complications
Intraoperative electron radiotherapy (IOERT) in colorectal cancer: Updated systematic review of techniques, oncological outcomes and complications Open
Although limited by a lack of appropriately conducted randomised evidence, IOERT-containing multi-modality treatment may improve oncological outcomes in LACC and LRCC patients with R1 resections.
View article: A Prospective Observational Cohort Study Comparing High-Complexity Against Conventional Pelvic Exenteration Surgery
A Prospective Observational Cohort Study Comparing High-Complexity Against Conventional Pelvic Exenteration Surgery Open
Background: Conventional pelvic exenteration (PE) comprises the removal of all or most central pelvic organs and is established in clinical practise. Previously, tumours involving bone or lateral sidewall structures were deemed inoperable …
View article: Targeted Genetic Sequencing Analysis of 223 Cases of Pseudomyxoma Peritonei Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Shows Survival Related to <scp><i>GNAS</i></scp> and <scp><i>KRAS</i></scp> Status
Targeted Genetic Sequencing Analysis of 223 Cases of Pseudomyxoma Peritonei Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Shows Survival Related to <span><i>GNAS</i></span> and <span><i>KRAS</i></span> Status Open
Background and Aim Pseudomyxoma peritonei (PMP) is an unusual condition with unique behaviour caused by a mucinous neoplasm, usually arising from the appendix. The aim of this study was to evaluate the prevalence of genomic alterations in …
View article: A Preliminary Phenomenological Exploration of Experiences of the Empty Pelvis Syndrome Derived From a Modified‐Delphi: The Price of Survival Following Pelvic Exenteration for Advanced Pelvic Cancer
A Preliminary Phenomenological Exploration of Experiences of the Empty Pelvis Syndrome Derived From a Modified‐Delphi: The Price of Survival Following Pelvic Exenteration for Advanced Pelvic Cancer Open
Objective The empty pelvis syndrome (EPS) is common after pelvic exenteration (PE), causing fluid collections, bowel obstruction, perineal sinuses, and fistulas. The best approach to fill the pelvis to mitigate this remains controversial, …
View article: Eureka: objective assessment of the empty pelvis syndrome to measure volumetric changes in pelvic dead space following pelvic exenteration
Eureka: objective assessment of the empty pelvis syndrome to measure volumetric changes in pelvic dead space following pelvic exenteration Open
Background Large tissue defects following pelvic exenteration (PE) fill with fluid and small bowel, leading to the empty pelvis syndrome (EPS). EPS causes a constellation of complications including pelvic sepsis and reduced quality of life…
View article: The empty pelvis syndrome: a core data set from the PelvEx collaborative
The empty pelvis syndrome: a core data set from the PelvEx collaborative Open
Background Empty pelvis syndrome (EPS) is a significant source of morbidity following pelvic exenteration (PE), but is undefined. EPS outcome reporting and descriptors of radicality of PE are inconsistent; therefore, the best approaches fo…
View article: ERCC1 abundance is an indicator of DNA repair-apoptosis decision upon DNA damage
ERCC1 abundance is an indicator of DNA repair-apoptosis decision upon DNA damage Open
DNA repair is essential for successful propagation of genetic material and fidelity of transcription. Nucleotide excision repair (NER) is one of the earliest DNA repair mechanisms, functionally conserved from bacteria to human. The fact th…
View article: Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer
Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer Open
Colorectal cancer (CRC) is the 2nd leading cause of cancer-related deaths worldwide, primarily due to the development of metastatic disease. The liver is the most frequently affected site. The metastatic cascade relies on a complex interac…
View article: Risk-reducing surgery for individuals with cancer-predisposing germline pathogenic variants and no personal cancer history: a review of current UK guidelines
Risk-reducing surgery for individuals with cancer-predisposing germline pathogenic variants and no personal cancer history: a review of current UK guidelines Open
View article: Supplementary Figure 4 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Figure 4 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 4417K, Control experiments.
View article: Supplementary Materials and Methods from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Materials and Methods from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 134K.
View article: Supplementary Genes from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Genes from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 20K, Results of DAVID bioinformatic analysis.
View article: Supplementary Figure 5 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Figure 5 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 3852K, Additional functional studies of miR-153 effect.
View article: Supplementary Figure 1 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Figure 1 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 4936K, MiRNA profiling concordance and summary DAVID data.
View article: Supplementary Materials and Methods from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Materials and Methods from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 134K.
View article: Supplementary Table 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Table 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 102K, Univariate analysis table.
View article: Supplementary Figure 3 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Figure 3 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 5326K, Copy number change in miR-153.
View article: Supplementary Table 1 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Table 1 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 86K, Patient clinicopathological data.
View article: Supplementary Genes from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Genes from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 20K, Results of DAVID bioinformatic analysis.
View article: Data from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Data from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
Although microRNAs (miRNA) have been broadly studied in cancer, comparatively less is understood about their role in progression. Here we report that miR-153 has a dual role during progression of colorectal cancer by enhancing cellular inv…
View article: Supplementary Figure Legends from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Figure Legends from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 65K.
View article: Supplementary Table 1 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Table 1 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 86K, Patient clinicopathological data.
View article: Supplementary Figure 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Figure 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 3629K, MiR-153 expression in pilot series of tumour samples.
View article: Supplementary Table 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Table 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 102K, Univariate analysis table.
View article: Supplementary Figure 3 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Figure 3 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 5326K, Copy number change in miR-153.
View article: Supplementary Figure 1 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Figure 1 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 4936K, MiRNA profiling concordance and summary DAVID data.
View article: Supplementary Figure 4 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Figure 4 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 4417K, Control experiments.
View article: Supplementary Figure 5 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Figure 5 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 3852K, Additional functional studies of miR-153 effect.
View article: Supplementary Figure 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance
Supplementary Figure 2 from miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Open
PDF file, 3629K, MiR-153 expression in pilot series of tumour samples.