Alex Horsley
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View article: Clinical and cost-effectiveness of diverse posthospitalisation pathways for COVID-19: a UK evaluation using the PHOSP-COVID cohort
Clinical and cost-effectiveness of diverse posthospitalisation pathways for COVID-19: a UK evaluation using the PHOSP-COVID cohort Open
Background Long covid has emerged as a complex health condition for millions of people worldwide following the COVID-19 pandemic. Previously, we have categorised healthcare pathways for patients after discharge from hospital with COVID-19 …
View article: Viscoplasticity can stabilize liquid collar motion on vertical cylinders
Viscoplasticity can stabilize liquid collar motion on vertical cylinders Open
Liquid films coating vertical cylinders can form annular liquid collars which translate downwards under gravity. We investigate the dynamics of a thin viscoplastic liquid film coating the interior or exterior of a vertical cylindrical tube…
View article: Lung clearance index in patients with cystic fibrosis: Can we avoid repeating the test three times?
Lung clearance index in patients with cystic fibrosis: Can we avoid repeating the test three times? Open
Multiple breath washout (MBW) testing and its derived measurements (e.g., lung clearance index (LCI)) are useful for measuring ventilation heterogeneity in patients with cystic fibrosis, monitoring disease progression, and assessing the re…
View article: T <sub>2</sub> *-weighted oxygen-enhanced pulmonary MRI in COPD is linked to resting and exertional functional measurements
T <sub>2</sub> *-weighted oxygen-enhanced pulmonary MRI in COPD is linked to resting and exertional functional measurements Open
Background T 2 *-weighted oxygen-enhanced MRI (T 2 *-OE-MRI) may directly assess pulmonary ventilation using oxygen as an inhaled tracer gas. It has shown promise in healthy volunteers (HVs) and cystic fibrosis but has yet to be demonstrat…
View article: The safety, physiological response, and repeatability of the incremental shuttle walk test in survivors of COVID-19
The safety, physiological response, and repeatability of the incremental shuttle walk test in survivors of COVID-19 Open
Introduction The incremental shuttle walk test (ISWT) may be a valuable tool for measuring exercise tolerance in patients after a hospital admission with COVID-19. However, the safety, physiological response, and repeatability of the ISWT …
View article: Breath of change: Evaluating the healthcare impact of the race-neutral Global Lung Initiative (GLI) 2022 on adults with cystic fibrosis
Breath of change: Evaluating the healthcare impact of the race-neutral Global Lung Initiative (GLI) 2022 on adults with cystic fibrosis Open
This study evaluates the clinical impact of transitioning from the GLI 2012 to the race-neutral GLI 2022 spirometry equations in people with cystic fibrosis (pwCF). Spirometry data from a large adult CF centre showed an increase in average…
View article: Readability and complexity of written information presented to hospitalised patients for trial consent during the COVID-19 pandemic in the UK: a retrospective document analysis
Readability and complexity of written information presented to hospitalised patients for trial consent during the COVID-19 pandemic in the UK: a retrospective document analysis Open
Objectives Patient information sheets (PISs) and informed consent forms (ICFs) are essential tools to communicate and document informed consent for clinical trial participation. These documents need to be easily understandable, especially …
View article: Supplementary code for "Viscoplasticity can stabilise liquid collar motion on vertical cylinders"
Supplementary code for "Viscoplasticity can stabilise liquid collar motion on vertical cylinders" Open
Code used to generate data in Shemilt et al. (2025) "Viscoplasticity can stabilise liquid collar motion on vertical cylinders".
View article: Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation
Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation Open
Objective Post-COVID syndrome involves prolonged symptoms with multisystem and functional impairment lasting ≥12 weeks after acute coronavirus disease 2019 (COVID-19). We aimed to determine the efficacy of exercise-based rehabilitation int…
View article: Vanzacaftor–tezacaftor–deutivacaftor versus elexacaftor–tezacaftor–ivacaftor in individuals with cystic fibrosis aged 12 years and older (SKYLINE Trials VX20-121-102 and VX20-121-103): results from two randomised, active-controlled, phase 3 trials
Vanzacaftor–tezacaftor–deutivacaftor versus elexacaftor–tezacaftor–ivacaftor in individuals with cystic fibrosis aged 12 years and older (SKYLINE Trials VX20-121-102 and VX20-121-103): results from two randomised, active-controlled, phase 3 trials Open
View article: Breathlessness in Long COVID: Exploring the Relationship between Symptoms, Lung Function Tests, and Functional Imaging Using Hyperpolarised Xenon MRI
Breathlessness in Long COVID: Exploring the Relationship between Symptoms, Lung Function Tests, and Functional Imaging Using Hyperpolarised Xenon MRI Open
View article: Lower Airway and Oral Microbiome Dysbiosis in Patients with Long COVID Post-Hospitalisation: A UK Multicentre, Prospective Cohort Study
Lower Airway and Oral Microbiome Dysbiosis in Patients with Long COVID Post-Hospitalisation: A UK Multicentre, Prospective Cohort Study Open
View article: Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study
Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study Open
UK Research and Innovation and National Institute for Health Research. The study was approved by the Leeds West Research Ethics Committee (20/YH/0225) and is registered on the ISRCTN Registry (ISRCTN10980107).
View article: Prevalence and Distribution of Musculoskeletal Symptoms in Cystic Fibrosis and Impacts on Daily Life
Prevalence and Distribution of Musculoskeletal Symptoms in Cystic Fibrosis and Impacts on Daily Life Open
Background Musculoskeletal problems are reported in the literature as a common problem for people with cystic fibrosis, with a range of aetiologies including an inflammatory arthritis. However, accurate data on the presentations and preval…
View article: Incidence of diabetes mellitus following hospitalisation for <scp>COVID</scp> ‐19 in the United Kingdom: A prospective observational study
Incidence of diabetes mellitus following hospitalisation for <span>COVID</span> ‐19 in the United Kingdom: A prospective observational study Open
Background People hospitalised for coronavirus disease 2019 (COVID‐19) have elevated incidence of diabetes. However, it is unclear whether this is due to shared risk factors, confounding or stress hyperglycaemia in response to acute illnes…
View article: Non-local impact of distal airway constrictions on patterns of inhaled particle deposition
Non-local impact of distal airway constrictions on patterns of inhaled particle deposition Open
Airway constriction and blockage in obstructive lung diseases cause ventilation heterogeneity and create barriers to effective drug deposition. Established computational particle-deposition models have not accounted for these impacts of di…
View article: Global Lung Function Initiative reference values for multiple breath washout indices
Global Lung Function Initiative reference values for multiple breath washout indices Open
Background Multiple breath washout is a lung function test based on tidal breathing that assesses lung volume and ventilation distribution. The aim of this analysis was to use the Global Lung Function Initiative methodology to develop all-…
View article: Prevalence and distribution of musculoskeletal symptoms in cystic fibrosis and impacts on daily life
Prevalence and distribution of musculoskeletal symptoms in cystic fibrosis and impacts on daily life Open
Background: Musculoskeletal problems are reported in the literature as a common problem for people with cystic fibrosis, with a range of aetiologies including an inflammatory arthritis. However, accurate data on the presentations and preva…
View article: 1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study
1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study Open
Background In patients with coronavirus disease 2019 (COVID-19) requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid ad…
View article: Diagnostic utility of electrocardiogram for screening of cardiac injury on cardiac magnetic resonance in post-hospitalised COVID-19 patients: a prospective multicenter study
Diagnostic utility of electrocardiogram for screening of cardiac injury on cardiac magnetic resonance in post-hospitalised COVID-19 patients: a prospective multicenter study Open
Post-hospitalised COVID-19 patients have more ECG abnormalities than controls. Normal ECGs, including normal repolarisation intervals, reliably exclude CMR abnormalities in male and female patients.
View article: Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK Open
View article: Chronic thromboembolic pulmonary hypertension is an uncommon complication of COVID-19: UK national surveillance and observational screening cohort studies
Chronic thromboembolic pulmonary hypertension is an uncommon complication of COVID-19: UK national surveillance and observational screening cohort studies Open
Background Pulmonary embolism (PE) is a well-recognised complication of coronavirus disease 2019 (COVID-19) infection, and chronic thromboembolic pulmonary disease with and without pulmonary hypertension (CTEPD/CTEPH) are potential life-li…
View article: Long COVID and cardiovascular disease: a prospective cohort study
Long COVID and cardiovascular disease: a prospective cohort study Open
Background Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following di…
View article: Randomised, phase 1/2a trial of ION-827359, an antisense oligonucleotide inhibitor of ENaC
Randomised, phase 1/2a trial of ION-827359, an antisense oligonucleotide inhibitor of ENaC Open
Background Hyperactivity of epithelial sodium channel (ENaC) with increased sodium absorption is a feature of cystic fibrosis (CF). ION-827359 is a 2.5-generation antisense oligonucleotide targeted to reduce ENaC protein. This study evalua…
View article: Supplementary code for "Non-local impact of distal airway constrictions on patterns of inhaled particle deposition"
Supplementary code for "Non-local impact of distal airway constrictions on patterns of inhaled particle deposition" Open
Code used for generation of results for Shemilt et al. (2024) "Non-local impact of distal airway constrictions on patterns of inhaled particle deposition".
View article: Standards of care and educational gaps in adult cystic fibrosis units: a European Respiratory Society survey
Standards of care and educational gaps in adult cystic fibrosis units: a European Respiratory Society survey Open
Background Significant progress in the field of cystic fibrosis (CF) has substantially extended the life expectancy of patients with CF (pwCF). Consequently, the population of adult pwCF has outnumbered paediatric patients in most develope…
View article: Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease Open
View article: Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study – PHOSP-COVID
Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study – PHOSP-COVID Open
Background The long-term outcomes of COVID-19 hospitalisation in individuals with pre-existing airway diseases are unknown. Methods Adult participants hospitalised for confirmed or clinically suspected COVID-19 and discharged between 5 Mar…
View article: Ecological patterns and processes of temporal turnover within lung infection microbiota
Ecological patterns and processes of temporal turnover within lung infection microbiota Open
Background Chronic infection and consequent airway inflammation are the leading causes of morbidity and early mortality for people living with cystic fibrosis (CF). However, lower airway infections across a range of chronic respiratory dis…
View article: A grumbling concern: A survey of gastrointestinal symptoms in cystic fibrosis in the modulator era
A grumbling concern: A survey of gastrointestinal symptoms in cystic fibrosis in the modulator era Open
Background Gastrointestinal symptoms in cystic fibrosis (CF) are common and intrusive to daily life. Relieving gastrointestinal symptoms was identified as an important research priority and previously explored in an international survey in…