Alex J. McDonald
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View article: High-speed voltage imaging of action potentials in molecular layer interneurons reveals sensory-driven synchrony that augments movement
High-speed voltage imaging of action potentials in molecular layer interneurons reveals sensory-driven synchrony that augments movement Open
Testing whether the synchrony of action potential firing is a cerebellar coding mechanism requires simultaneous recording, with high temporal fidelity, from populations of identified neurons. Here, we used targeted one-photon voltage imagi…
View article: Anti-NMDA receptor encephalitis: a case study and illness overview
Anti-NMDA receptor encephalitis: a case study and illness overview Open
Anti-N-methyl D-aspartate (NMDA) receptor (anti-NMDAR) encephalitis is among one of the most common autoimmune encephalitides. However, variations in clinical presentation and nonsequential multiphasic course often lead to delays in diagno…
View article: An inter-domain regulatory mechanism controls toxic activities of PrP<sup>C</sup>
An inter-domain regulatory mechanism controls toxic activities of PrP<sup>C</sup> Open
The normal function of PrPC, the cellular prion protein, has remained mysterious since its first description over 30 years ago. Amazingly, although complete deletion of the gene encoding PrPC has little phenotypic consequence, expression i…
View article: The N-terminus of the prion protein is a toxic effector regulated by the C-terminus
The N-terminus of the prion protein is a toxic effector regulated by the C-terminus Open
PrPC, the cellular isoform of the prion protein, serves to transduce the neurotoxic effects of PrPSc, the infectious isoform, but how this occurs is mysterious. Here, using a combination of electrophysiological, cellular, and biophysical t…
View article: Author response: The N-terminus of the prion protein is a toxic effector regulated by the C-terminus
Author response: The N-terminus of the prion protein is a toxic effector regulated by the C-terminus Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract PrPC, the cellular isoform of the prion protein…
View article: Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation
Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation Open
The cellular prion protein (Pr P C ) comprises a natively unstructured N‐terminal domain, including a metal‐binding octarepeat region ( OR ) and a linker, followed by a C‐terminal domain that misfolds to form Pr P S c in Creutzfeldt‐Jakob …