Alex K. Bryant
YOU?
Author Swipe
View article: The effect of common medications on the efficacy of immune checkpoint inhibitors
The effect of common medications on the efficacy of immune checkpoint inhibitors Open
Background Medications such as proton pump inhibitors (PPIs), antihistamines, and nonsteroidal anti‐inflammatory drugs have been linked to immune checkpoint inhibitor (ICI) efficacy in patients with non–small cell lung cancer (NSCLC), but …
View article: Supplemental Tables 1-4 from Liver Metastases License Neutrophils through IL1 to Potentiate Cancer Progression
Supplemental Tables 1-4 from Liver Metastases License Neutrophils through IL1 to Potentiate Cancer Progression Open
Supplemental Tables 1-4 describing patient characteristics of clinical cohorts
View article: Supplemental Figure 2 from Liver Metastases License Neutrophils through IL1 to Potentiate Cancer Progression
Supplemental Figure 2 from Liver Metastases License Neutrophils through IL1 to Potentiate Cancer Progression Open
Supplemental Figure 2: Liver metastasis promotes cancer progression in preclinical models.
View article: Identifying Optimal Candidates for PSMA PET Staging of Newly Diagnosed Intermediate Risk Prostate Cancer: A Report from the National Veterans Affairs System
Identifying Optimal Candidates for PSMA PET Staging of Newly Diagnosed Intermediate Risk Prostate Cancer: A Report from the National Veterans Affairs System Open
View article: Increasing Value in the Veterans Affairs Healthcare System (VA) with Precision Health: A Continuing Landmark Collaboration with the Department of Energy
Increasing Value in the Veterans Affairs Healthcare System (VA) with Precision Health: A Continuing Landmark Collaboration with the Department of Energy Open
Objective By personalizing healthcare to an individual’s specific requirements, precision health promises to maximize benefit and minimize harm, thereby maximizing value. We describe here, how in Phase 2 of the Million Veteran Program–Comp…
View article: The Contribution of Cirrhosis Progression in Liver Dysfunction After Stereotactic Body Radiation Therapy
The Contribution of Cirrhosis Progression in Liver Dysfunction After Stereotactic Body Radiation Therapy Open
A significant proportion of post-SBRT liver function decline is due to the natural progression of cirrhotic liver dysfunction, and this proportion increases with time. These findings should improve estimates of SBRT treatment toxicity.
View article: Prostate Cancer Mortality in Men Aged 70 Years Who Recently Underwent Prostate-Specific Antigen Screening
Prostate Cancer Mortality in Men Aged 70 Years Who Recently Underwent Prostate-Specific Antigen Screening Open
Importance Continuing prostate-specific antigen (PSA) screening after age 70 years might benefit men at high risk of prostate cancer–specific mortality (PCSM) or metastatic prostate cancer (mPCa), but the relative value of clinical factors…
View article: Intricacies of human–AI interaction in dynamic decision-making for precision oncology
Intricacies of human–AI interaction in dynamic decision-making for precision oncology Open
AI decision support systems can assist clinicians in planning adaptive treatment strategies that can dynamically react to individuals’ cancer progression for effective personalized care. However, AI’s imperfections can lead to suboptimal t…
View article: Lung cancer screening in India: Preparing for the future using smart tools & biomarkers to identify highest risk individuals
Lung cancer screening in India: Preparing for the future using smart tools & biomarkers to identify highest risk individuals Open
There is a growing burden of lung cancer cases in India, incidence projected to increase from 63,708 cases (2015) to 81,219 cases (2025). The increasing numbers are attributed to smoking (India currently has nearly 100 million adult smoker…
View article: Brief Report: Real-World Outcomes of Lurbinectedin in Veterans with Small Cell Lung Cancer
Brief Report: Real-World Outcomes of Lurbinectedin in Veterans with Small Cell Lung Cancer Open
View article: Effectiveness and safety of immune checkpoint inhibitors in Black patients versus White patients in a US national health system: a retrospective cohort study
Effectiveness and safety of immune checkpoint inhibitors in Black patients versus White patients in a US national health system: a retrospective cohort study Open
Million Veteran Program, Office of Research and Development, Veterans Health Administration and the LUNGevity foundation.
View article: Pan‐Cancer Survival Impact of Immune Checkpoint Inhibitors in a National Healthcare System
Pan‐Cancer Survival Impact of Immune Checkpoint Inhibitors in a National Healthcare System Open
Background The cumulative, health system‐wide survival benefit of immune checkpoint inhibitors (ICIs) is unclear, particularly among real‐world patients with limited life expectancies and among subgroups poorly represented on clinical tria…
View article: SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma
SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma Open
End-stage liver disease is marked by portal hypertension, systemic elevations in ammonia, and development of hepatocellular carcinoma (HCC). While these clinical consequences of cirrhosis are well described, it remains poorly understood wh…
View article: A randomized controlled educational study to evaluate an e-learning module to teach the physical examination of the temporomandibular joint in juvenile idiopathic arthritis
A randomized controlled educational study to evaluate an e-learning module to teach the physical examination of the temporomandibular joint in juvenile idiopathic arthritis Open
View article: SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma
SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma Open
End stage liver disease is marked by portal hypertension, systemic elevations in ammonia, and development of hepatocellular carcinoma (HCC). While these clinical consequences of cirrhosis are well described, it remains poorly understood wh…
View article: Quantifying the Risk of Technology-Driven Health Disparities in Radiation Oncology
Quantifying the Risk of Technology-Driven Health Disparities in Radiation Oncology Open
The proposed methodology may simplify the evaluation of how new technology impacts vulnerable populations, help clinics quantify the limitations of their technological resources, and plan appropriate interventions to improve equity in radi…
View article: Artificial intelligence to unlock <scp>real‐world</scp> evidence in clinical oncology: A primer on recent advances
Artificial intelligence to unlock <span>real‐world</span> evidence in clinical oncology: A primer on recent advances Open
Purpose Real world evidence is crucial to understanding the diffusion of new oncologic therapies, monitoring cancer outcomes, and detecting unexpected toxicities. In practice, real world evidence is challenging to collect rapidly and compr…
View article: Intricacies of Human-AI Interaction in Dynamic Decision-Making for Precision Oncology: A Case Study in Response-Adaptive Radiotherapy
Intricacies of Human-AI Interaction in Dynamic Decision-Making for Precision Oncology: A Case Study in Response-Adaptive Radiotherapy Open
Background Adaptive treatment strategies that can dynamically react to individual cancer progression can provide effective personalized care. Longitudinal multi-omics information, paired with an artificially intelligent clinical decision s…
View article: Adrenal-Permissive Germline <i>HSD3B1</i> Allele and Prostate Cancer Outcomes
Adrenal-Permissive Germline <i>HSD3B1</i> Allele and Prostate Cancer Outcomes Open
Importance The adrenal androgen–metabolizing 3β-hydroxysteroid dehydrogenase-1 enzyme, encoded by the HSD3B1 gene, catalyzes the rate-limiting step necessary for synthesizing nontesticular testosterone and dihydrotestosterone production. T…
View article: Lung Cancer Survival Trends in the Veterans Health Administration
Lung Cancer Survival Trends in the Veterans Health Administration Open
View article: An NLP Framework for the Extraction of Concept Measurements from Radiology and Pathology Notes
An NLP Framework for the Extraction of Concept Measurements from Radiology and Pathology Notes Open
Natural language processing (NLP) tools can automate the identification of cancer patients eligible for specific pathways. We developed and validated a cancer agnostic, rules-based NLP framework to extract the dimensions and measurements o…
View article: Genetic risk and likelihood of prostate cancer detection on first biopsy by ancestry
Genetic risk and likelihood of prostate cancer detection on first biopsy by ancestry Open
Despite differences in prostate cancer risk across ancestry groups, relative performance of prostate cancer genetic risks scores (GRS) for positive biopsy prediction in different ancestry groups is unknown. This cross-sectional retrospecti…
View article: Association between prediagnostic prostate‐specific antigen and prostate cancer probability in Black and non‐Hispanic White men
Association between prediagnostic prostate‐specific antigen and prostate cancer probability in Black and non‐Hispanic White men Open
Background Although Black men are more likely than non‐Hispanic White men to develop and die from prostate cancer, limited data exist to guide prostate‐specific antigen (PSA) screening protocols in Black men. This study investigated whethe…
View article: Adopting Weight-Based Dosing With Pharmacy-Level Stewardship Strategies Could Reduce Cancer Drug Spending By Millions
Adopting Weight-Based Dosing With Pharmacy-Level Stewardship Strategies Could Reduce Cancer Drug Spending By Millions Open
Immune checkpoint inhibitors, a class of drugs used in approximately forty unique cancer indications, are a sizable component of the economic burden of cancer care in the US. Instead of personalized weight-based dosing, immune checkpoint i…
View article: Prospective Evaluation of Limited-Stage Small Cell Lung Cancer Radiotherapy Fractionation Regimen Usage and Acute Toxicity in a Large Statewide Quality Collaborative
Prospective Evaluation of Limited-Stage Small Cell Lung Cancer Radiotherapy Fractionation Regimen Usage and Acute Toxicity in a Large Statewide Quality Collaborative Open
View article: Supplemental Table S2 from Trends in Radiation Therapy among Cancer Survivors in the United States, 2000–2030
Supplemental Table S2 from Trends in Radiation Therapy among Cancer Survivors in the United States, 2000–2030 Open
Our primary analysis assumed that projected incidence and survival trends would continue based on historical trends. Supplemental Table S2 demonstrates the number of radiation-treated cancer survivors when assuming constant cancer incidenc…
View article: Supplementary Table from Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data
Supplementary Table from Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data Open
Supplementary Table from Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data
View article: Supplementary Table from Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data
Supplementary Table from Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data Open
Supplementary Table from Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data
View article: Supplementary Table from Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data
Supplementary Table from Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data Open
Supplementary Table from Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data
View article: Supplementary Table from Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data
Supplementary Table from Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data Open
Supplementary Table from Bias Reduction through Analysis of Competing Events (BRACE) Correction to Address Cancer Treatment Selection Bias in Observational Data