Alex M. Laliberté
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View article: Poly-L-Ornithine coated plant scaffolds support motor recovery in rats after traumatic spinal cord injury
Poly-L-Ornithine coated plant scaffolds support motor recovery in rats after traumatic spinal cord injury Open
Spinal cord injury (SCI) is a debilitating neurological condition with far-reaching consequences for patients, including loss of motor function and significant limitations to quality of life. Implantable biomaterials have emerged as a ther…
View article: Sensorimotor circuits formed by dI3 neurons have distinct connectivity within and across the lumbar and cervical spinal cord
Sensorimotor circuits formed by dI3 neurons have distinct connectivity within and across the lumbar and cervical spinal cord Open
We used an isolated mouse spinal cord preparation to optogenetically stimulate individual subpopulations of dI3 neurons. We investigated for the first time the specific connectivity patterns of dI3 neurons and demonstrated that they activa…
View article: Spinal dI3 neurons are involved in sustained motor adaptation elicited by low-threshold cutaneous afferents
Spinal dI3 neurons are involved in sustained motor adaptation elicited by low-threshold cutaneous afferents Open
Adaptation of muscle activity to meet a certain target or intention is traditionally attributed to supraspinal structures. However, evidence is mounting that this process can occur within the spinal cord through intrinsic plasticity and ci…
View article: Altered excitability of dI3 neurons regulates hindlimb motor tone and locomotor recovery after spinal cord injury
Altered excitability of dI3 neurons regulates hindlimb motor tone and locomotor recovery after spinal cord injury Open
Recovery of motor function after spinal cord injury is limited in mammals. Reactivation of locomotor circuits does occur, but primarily through the activation of sensorimotor pathways in the context of locomotor training. Previous investig…
View article: Evidence of spinal cord comparator modules for rapid corrections of movements
Evidence of spinal cord comparator modules for rapid corrections of movements Open
Successful movement requires continuous adjustments in response to changes in internal and external environments. To do so, neural circuits continuously compare efference copies of motor commands with sensory input to respond to sensory pr…
View article: An optogenetic mouse model of hindlimb spasticity after spinal cord injury
An optogenetic mouse model of hindlimb spasticity after spinal cord injury Open
View article: Mapping of dI3 neuron sensorimotor circuits across the cervical and lumbar spinal cord
Mapping of dI3 neuron sensorimotor circuits across the cervical and lumbar spinal cord Open
From the fine control of hand movements to the dynamic corrective adjustments during locomotion, spinal circuits integrate descending supraspinal and sensory inputs to modulate diverse motor functions. The integration of such a wide range …
View article: C.3 Retrospective study of sulthiame in treatment of pediatric epilepsy
C.3 Retrospective study of sulthiame in treatment of pediatric epilepsy Open
Background: This retrospective study assessed the efficacy and tolerability of sulthiame as a treatment in children with epilepsy. In Canada, sulthiame is only available through Health Canada’s Special Access Program. Methods: Patients who…
View article: Changes in Sensorimotor Connectivity to dI3 Interneurons in Relation to the Postnatal Maturation of Grasping
Changes in Sensorimotor Connectivity to dI3 Interneurons in Relation to the Postnatal Maturation of Grasping Open
Primitive reflexes are evident shortly after birth. Many of these reflexes disappear during postnatal development as part of the maturation of motor control. This study investigates the changes of connectivity related to sensory integratio…
View article: The influence of ApoE4 on the clinical outcomes and pathophysiology of degenerative cervical myelopathy
The influence of ApoE4 on the clinical outcomes and pathophysiology of degenerative cervical myelopathy Open
Degenerative cervical myelopathy (DCM) is the most common cause of nontraumatic spinal cord injury in adults worldwide. Surgical decompression is generally effective in improving neurological outcomes and halting progression of myelopathic…
View article: <i>Mir21</i> modulates inflammation and sensorimotor deficits in cervical myelopathy: data from humans and animal models
<i>Mir21</i> modulates inflammation and sensorimotor deficits in cervical myelopathy: data from humans and animal models Open
Degenerative cervical myelopathy is a common condition resulting from chronic compression of the spinal cord by degenerating structures of the spine. Degenerative cervical myelopathy present a wide range of outcomes, and the biological fac…
View article: Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal Cord
Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal Cord Open
Propriospinal interneurons (INs) communicate information over short and long distances within the spinal cord. They act to coordinate different parts of the body by linking motor circuits that control muscles across the forelimbs, trunk, a…
View article: Corrigendum to “Generating level-dependent models of cervical and thoracic spinal cord injury: Exploring the interplay of neuroanatomy, physiology, and function” Neurobiology of Disease 105 (2017) 194–212
Corrigendum to “Generating level-dependent models of cervical and thoracic spinal cord injury: Exploring the interplay of neuroanatomy, physiology, and function” Neurobiology of Disease 105 (2017) 194–212 Open
View article: Delayed decompression exacerbates ischemia-reperfusion injury in cervical compressive myelopathy
Delayed decompression exacerbates ischemia-reperfusion injury in cervical compressive myelopathy Open
Degenerative cervical myelopathy (DCM) is the most common progressive nontraumatic spinal cord injury. The most common recommended treatment is surgical decompression, although the optimal timing of intervention is an area of ongoing debat…
View article: Generating level-dependent models of cervical and thoracic spinal cord injury: Exploring the interplay of neuroanatomy, physiology, and function
Generating level-dependent models of cervical and thoracic spinal cord injury: Exploring the interplay of neuroanatomy, physiology, and function Open
View article: Early Intravenous Delivery of Human Brain Stromal Cells Modulates Systemic Inflammation and Leads to Vasoprotection in Traumatic Spinal Cord Injury
Early Intravenous Delivery of Human Brain Stromal Cells Modulates Systemic Inflammation and Leads to Vasoprotection in Traumatic Spinal Cord Injury Open
Spinal cord injury (SCI) is a life-threatening condition with multifaceted complications and limited treatment options. In SCI, the initial physical trauma is closely followed by a series of secondary events, including inflammation and blo…