Alex Menys
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View article: Volumetric Changes in Perianal Fistulizing Crohn's Disease Measured by Magnetic Resonance Is Feasible and Could Be a Potential Biomarker to Predict Clinical Outcomes
Volumetric Changes in Perianal Fistulizing Crohn's Disease Measured by Magnetic Resonance Is Feasible and Could Be a Potential Biomarker to Predict Clinical Outcomes Open
Background and Aim Changes in 3D volumetry of perianal fistulas in patients with Crohn's disease (CD) measured by MRI could be an imaging biomarker of interest. The objective of the study was to determine the value of volumetric changes in…
View article: Magnetic Resonance Imaging-based ileal motility quantification predicts stricture response to biologic therapy in Crohn's disease.
Magnetic Resonance Imaging-based ileal motility quantification predicts stricture response to biologic therapy in Crohn's disease. Open
Objective Strictures are a common feature of Crohn’s disease (CD), impairing bowel function, complicating treatment, and often leading to surgery. Predicting which lesions are responsive to medical therapy and which will become obstructive…
View article: MRI assessment of body composition for prediction of therapeutic response to biologic agents in patients with Crohn’s disease
MRI assessment of body composition for prediction of therapeutic response to biologic agents in patients with Crohn’s disease Open
View article: Small Bowel Motility Quantified by Cine MRI to Predict Longer-Term Response in Patients with Crohn’s Disease Commencing Biological Therapy: The Motility Study
Small Bowel Motility Quantified by Cine MRI to Predict Longer-Term Response in Patients with Crohn’s Disease Commencing Biological Therapy: The Motility Study Open
Background Small bowel Crohn’s disease (SBCD) is increasingly treated with biological therapies. Predicting response or remission (RoR) for individual patients is difficult and complicates treatment strategy. We aimed to determine if motil…
View article: Diffusion-weighted imaging to predict longer-term response in Crohn’s disease patients commencing biological therapy: results from the MOTILITY trial
Diffusion-weighted imaging to predict longer-term response in Crohn’s disease patients commencing biological therapy: results from the MOTILITY trial Open
Objectives Predicting longer-term response to biological therapy for small bowel Crohn’s disease (SBCD) is an unmet clinical need. Diffusion-weighted magnetic resonance (MR) imaging (DWI) may indicate disease activity, but its predictive a…
View article: Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study
Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study Open
Background Colonic motility in constipation can be assessed non-invasively using MRI. Objective To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response. Design Part 1: 44 healthy volunteers (HVs), 43 …
View article: Volumetric measurement of terminal ileal Crohn’s disease by magnetic resonance enterography: a feasibility study
Volumetric measurement of terminal ileal Crohn’s disease by magnetic resonance enterography: a feasibility study Open
Objectives Magnetic resonance enterography (MRE) interpretation of Crohn’s disease (CD) is subjective and uses 2D analysis. We evaluated the feasibility of volumetric measurement of terminal ileal CD on MRE compared to endoscopy and sMARIA…
View article: A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study.
A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes: a pilot study. Open
Background People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve …
View article: Mechanisms underlying the laxative effect of lactulose: A randomized placebo‐controlled trial showing increased small bowel water and motility unaltered by the <scp>5‐HT<sub>3</sub></scp> receptor antagonist, ondansetron
Mechanisms underlying the laxative effect of lactulose: A randomized placebo‐controlled trial showing increased small bowel water and motility unaltered by the <span>5‐HT<sub>3</sub></span> receptor antagonist, ondansetron Open
Background Lactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of diarrhea to investigate the anti‐diarrheal actions of ondansetron. Methods A double‐bl…
View article: COMPARING MAGNETIC RESONANCE ENTEROGRAPHY AND ENDOSCOPY FINDINGS TO QUANTATATIVE MAGENTIC RESONANCE IMAGING IN PEDIATRIC CROHN’S DISEASE
COMPARING MAGNETIC RESONANCE ENTEROGRAPHY AND ENDOSCOPY FINDINGS TO QUANTATATIVE MAGENTIC RESONANCE IMAGING IN PEDIATRIC CROHN’S DISEASE Open
BACKGROUND In pediatric Crohn’s disease, endoscopy has remained the gold standard for diagnosis; however, Magnetic Resonance Enterography (MRE) is able to show inflammation of the bowel that a gastroenterologist cannot reach with endoscopy…
View article: P670 Intestinal Motility Changes in Patients Undergoing Removable Stent Treatment for Focal Crohn’s Disease Strictures
P670 Intestinal Motility Changes in Patients Undergoing Removable Stent Treatment for Focal Crohn’s Disease Strictures Open
Background Management and assessment of fibrostenotic Crohn’s disease(CD) is a research priority. Deep phenotyping is key for effective therapeutic development. In this study, we explore MRI assessed bowel motility before and after endosco…
View article: P013 Magnetic Resonance Imaging-Based Average T2 Signal as A Non-Invasive Measure of Fibrosis In Enteric Crohn’s Disease
P013 Magnetic Resonance Imaging-Based Average T2 Signal as A Non-Invasive Measure of Fibrosis In Enteric Crohn’s Disease Open
Background In Crohn’s Disease (CD), 10% of patients present with fibrostenosis with a further 10% progressing from inflammatory to a fibrostenotic disease behaviour over 7 years. 40% of fibrostenotic CD patients need surgery at 5 years com…
View article: A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes.
A randomised crossover trial of tezacaftor-ivacaftor for gut dysfunction in cystic fibrosis with magnetic resonance imaging (MRI) outcomes. Open
Background People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve …
View article: P214 Cine MRI assessment of colonic motility in patients with ulcerative colitis associated constipation.
P214 Cine MRI assessment of colonic motility in patients with ulcerative colitis associated constipation. Open
Background Constipation may be a feature of ulcerative colitis (uc) especially in left sided or distal disease. UC associated constipation (UCAC) can cause significant morbidity; treatment is typically with dietary fibre changes and laxati…
View article: Magnetic resonance imaging assessed enteric motility and luminal content analysis in patients with severe bloating and visible distension
Magnetic resonance imaging assessed enteric motility and luminal content analysis in patients with severe bloating and visible distension Open
Background Gastrointestinal symptoms in functional gut disorders occur without any discernible structural gut abnormality. Preliminary observations on enteric MRI suggest possible abnormal content and motility of the terminal ileum (TI) in…
View article: Impact of bowel dilation on small bowel motility measurements with cine-MRI: assessment of two quantification techniques
Impact of bowel dilation on small bowel motility measurements with cine-MRI: assessment of two quantification techniques Open
Objectives: To evaluate the effect of bowel dilation on cine-MRI small bowel motility measurements, by comparing a conventional motility score (including bowel wall and lumen) with a bowel wall-specific motility score in healthy and diseas…
View article: Cardiac-induced liver deformation as a measure of liver stiffness using dynamic imaging without magnetization tagging—preclinical proof-of-concept, clinical translation, reproducibility and feasibility in patients with cirrhosis
Cardiac-induced liver deformation as a measure of liver stiffness using dynamic imaging without magnetization tagging—preclinical proof-of-concept, clinical translation, reproducibility and feasibility in patients with cirrhosis Open
View article: Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls
Magnetic resonance imaging of the gastrointestinal tract shows reduced small bowel motility and altered chyme in cystic fibrosis compared to controls Open
Cystic fibrosis (CF) is a genetic disease affecting mucosal secretions. Most patients experience digestive symptoms, but the mechanisms are incompletely understood. Here we explore causes and consequences of slower gastrointestinal transit…
View article: Simultaneous assessment of colon motility in children with functional constipation by cine-MRI and colonic manometry: a feasibility study
Simultaneous assessment of colon motility in children with functional constipation by cine-MRI and colonic manometry: a feasibility study Open
View article: MR Measures of Small Bowel Wall <scp>T2</scp> Are Associated With Increased Permeability
MR Measures of Small Bowel Wall <span>T2</span> Are Associated With Increased Permeability Open
Background Increased small bowel permeability leads to bacterial translocation, associated with significant morbidity and mortality. Biomarkers are needed to evaluate these changes in vivo, stratify an individual's risk, and evaluate the e…
View article: Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants
Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants Open
Objective The gastrointestinal environment in which drug products need to disintegrate before the drug can dissolve and be absorbed has not been studied in detail due to limitations, especially invasiveness of existing techniques. Minimal …
View article: Serum Scoring and Quantitative Magnetic Resonance Imaging in Intestinal Failure-Associated Liver Disease: A Feasibility Study
Serum Scoring and Quantitative Magnetic Resonance Imaging in Intestinal Failure-Associated Liver Disease: A Feasibility Study Open
(1) Background: Intestinal failure-associated liver disease (IFALD) in adults is characterized by steatosis with variable progression to fibrosis/cirrhosis. Reference standard liver biopsy is not feasible for all patients, but non-invasive…
View article: The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge
The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge Open
Background Magnetic resonance imaging (MRI) of the colonic response to a macrogol challenge drink can be used to assess the mechanisms underlying severe constipation. We measured the intrasubject reproducibility of MRI measures of colonic …
View article: Gastrointestinal peptides and small-bowel hypomotility are possible causes for fasting and postprandial symptoms in active Crohn’s disease
Gastrointestinal peptides and small-bowel hypomotility are possible causes for fasting and postprandial symptoms in active Crohn’s disease Open
View article: Spatio‐temporal motility MRI analysis of the stomach and colon
Spatio‐temporal motility MRI analysis of the stomach and colon Open
Background MRI is increasingly used to objectively assess gastrointestinal motility. However, motility metrics often do not offer insights into the nature of contractile action. This study introduces a systematic method of making spatio‐te…
View article: Detecting the effects of a standardized meal challenge on small bowel motility with MRI in prepared and unprepared bowel
Detecting the effects of a standardized meal challenge on small bowel motility with MRI in prepared and unprepared bowel Open
Objective MRI is increasingly used to evaluate small bowel contractility. The objective of this study was to validate a clinically practical stimulation test (300‐kcal meal) for small bowel motility. Methods Thirty‐one healthy subjects und…
View article: Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: Beyond the breath‐hold
Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: Beyond the breath‐hold Open
Background The symptoms of functional bowel disorders are common in postprandial but investigations are generally undertaken in the fasted state using invasive procedures. MRI provides a noninvasive tool to study the gastrointestinal tract…
View article: Relationship between MRI quantified small bowel motility and abdominal symptoms in Crohn’s disease patients—a validation study
Relationship between MRI quantified small bowel motility and abdominal symptoms in Crohn’s disease patients—a validation study Open
objective: Previous single-centre MRI data suggests an inverse correlation between normal small bowel motility variance and abdominal symptoms in Crohn's disease (CD) patients. The current work prospectively assesses this observation in a …
View article: PWE-041 Alteration in small bowel motility, gut peptides and patient’s symptoms in active crohn’s disease
PWE-041 Alteration in small bowel motility, gut peptides and patient’s symptoms in active crohn’s disease Open
Introduction Intestinal inflammation in Crohn's disease (CD) is associated with an increase in Polypeptide YY (PYY), Glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK). CD patients experience postprandial fullness and nausea. These …
View article: Dynamic MRI for bowel motility imaging–how fast and how long?
Dynamic MRI for bowel motility imaging–how fast and how long? Open
A temporal resolution of at least 1 fps and a scan duration of at least 15 s is necessary in breath-hold scans for consistent motility observations. The majority of small bowel motility studies to date are in line with these requirements. …