Alex Rigby
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View article: A Murine Model of Radionuclide Lung Contamination for the Evaluation of Americium Decorporation Treatments
A Murine Model of Radionuclide Lung Contamination for the Evaluation of Americium Decorporation Treatments Open
The hydroxypyridinone ligand 3,4,3-LI(1,2-HOPO) (HOPO), has been previously characterized as a promising chelating agent for in vivo decorporation of actinides, with decorporation being the removal of internally deposited contaminants from…
View article: Synthesis and Evaluation of a Bifunctional Chelator for Thorium-227 Targeted Radiotherapy
Synthesis and Evaluation of a Bifunctional Chelator for Thorium-227 Targeted Radiotherapy Open
Thorium-227 (227Th) is an α-emitting radionuclide currently under investigation for targeted alpha therapy. Available chelators used for this isotope suffer from challenging multistep syntheses. Here, we present the synthesis and preclinic…
View article: Maleic anhydride derived diphosphines: adaptable chelators for receptor-targeted <sup>99m</sup>Tc, <sup>64</sup>Cu and <sup>188</sup>Re radiotracers
Maleic anhydride derived diphosphines: adaptable chelators for receptor-targeted <sup>99m</sup>Tc, <sup>64</sup>Cu and <sup>188</sup>Re radiotracers Open
Two new, versatile bis(phosphino)maleic anhydride platforms enable facile preparation of diphosphine bioconjugates that can be simply radiolabelled with 99m Tc for SPECT imaging, 64 Cu for PET imaging and 188 Re for systemic radiotherapy.
View article: Perfusion-Independent Tissue Hypoxia in Cardiac Hypertrophy in Mice Measured by<sup>64</sup>Cu-CTS PET Imaging
Perfusion-Independent Tissue Hypoxia in Cardiac Hypertrophy in Mice Measured by<sup>64</sup>Cu-CTS PET Imaging Open
Background Hypoxia is central to many cardiac pathologies, but clinically its presence can only be inferred by indirect biomarkers including hypoperfusion and energetic compromise. Imaging hypoxia directly could offer new opportunities for…
View article: In Vivo Trafficking of the Anticancer Drug Tris(8-Quinolinolato) Gallium (III) (KP46) by Gallium-68/67 PET/SPECT Imaging
In Vivo Trafficking of the Anticancer Drug Tris(8-Quinolinolato) Gallium (III) (KP46) by Gallium-68/67 PET/SPECT Imaging Open
KP46 (tris(hydroxyquinolinato)gallium(III)) is an experimental, orally administered anticancer drug. Its absorption, delivery to tumours, and mode of action are poorly understood. We aimed to gain insight into these issues using gallium-67…
View article: Researching Green Process Innovation Across Borders and Boundaries Through Collaborative Inquiry
Researching Green Process Innovation Across Borders and Boundaries Through Collaborative Inquiry Open
Research involving multistakeholder collaborative partnerships is growing, as both academia and funding agencies align their objectives with societal challenges and undertake research in the context of application. In particular, the UN su…
View article: CCDC 2202474: Experimental Crystal Structure Determination
CCDC 2202474: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Probing Unexpected Reactivity in Radiometal Chemistry: Indium-111-Mediated Hydrolysis of Hybrid Cyclen-Hydroxypyridinone Ligands
Probing Unexpected Reactivity in Radiometal Chemistry: Indium-111-Mediated Hydrolysis of Hybrid Cyclen-Hydroxypyridinone Ligands Open
Chelators based on hydroxypyridinones have utility in incorporating radioactive metal ions into diagnostic and therapeutic agents used in nuclear medicine. Over the course of our hydroxypyridinone studies, we have prepared two novel chelat…
View article: CCDC 2115641: Experimental Crystal Structure Determination
CCDC 2115641: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: An interactive visualisation tool to manage metadata in engaged research projects, track progress, map stakeholders, and evaluate output, outcomes and impacts.
An interactive visualisation tool to manage metadata in engaged research projects, track progress, map stakeholders, and evaluate output, outcomes and impacts. Open
Increasingly, funded research projects are expected to address critical societal challenges. These challenges require generating and integrating multi-disciplinary and practical knowledge through collaboration among different actors. Corre…
View article: Physically motivated moment-tensor decomposition for mining-induced seismicity
Physically motivated moment-tensor decomposition for mining-induced seismicity Open
Compared to existing schemes, the decomposition of moment tensors for mining-induced seismic events into closing-crack and double-couple components has the advantage that each can be interpreted in terms of a physical source process (excav…
View article: Auger Electron-Emitting Radionuclides in Radiopharmaceutical Therapy
Auger Electron-Emitting Radionuclides in Radiopharmaceutical Therapy Open
Radionuclides that emit Auger electrons have great potential for treating cancers for which other treatments are not successful, especially for targeting (or even preventing) disseminated, metastatic cancers. Because of their low energies,…
View article: Toward Bifunctional Chelators for Thallium-201 for Use in Nuclear Medicine
Toward Bifunctional Chelators for Thallium-201 for Use in Nuclear Medicine Open
Auger electron therapy exploits the cytotoxicity of low-energy electrons emitted during radioactive decay that travel very short distances (typically 201Tl, with a half-life of 73 h, emits ∼37 Auger and other secondary electrons per decay …
View article: Description of seismic sources in underground mines: Dynamic stress fracturing around tunnels and strainbursting
Description of seismic sources in underground mines: Dynamic stress fracturing around tunnels and strainbursting Open
This paper considers dynamic fracturing of the rockmass surrounding a tunnel statically loaded by compressional stress as a possible source of seismic events in underground mines. This begins with two-dimensional dynamic modelling of failu…
View article: To Chelate Thallium(I) - Synthesis and Evaluation of Kryptofix-based Chelators for 201Tl
To Chelate Thallium(I) - Synthesis and Evaluation of Kryptofix-based Chelators for 201Tl Open
While best known for its toxic properties, thallium has also been explored for applications in nuclear diagnostics and medicine. Indeed, [201Tl]TlCl has been used extensively for nuclear imaging in the past before it was superceded by othe…
View article: Non-invasive radionuclide imaging of trace metal trafficking in health and disease: “PET metallomics”
Non-invasive radionuclide imaging of trace metal trafficking in health and disease: “PET metallomics” Open
Radioactive isotopes of elements from across the periodic table allow for non-invasive imaging of essential metals in health and disease.
View article: To chelate thallium( <scp>i</scp> ) – synthesis and evaluation of Kryptofix-based chelators for <sup>201</sup> Tl
To chelate thallium( <span>i</span> ) – synthesis and evaluation of Kryptofix-based chelators for <sup>201</sup> Tl Open
The synthesis and characterisation of a series of Kryptofix 222-based chelators that can be radiolabelled with 201 Tl( i ) in high radiochemical yields at ambient temperature are described.
View article: Targeted Auger electron-emitter therapy: Radiochemical approaches for thallium-201 radiopharmaceuticals
Targeted Auger electron-emitter therapy: Radiochemical approaches for thallium-201 radiopharmaceuticals Open
Decay of [201Tl]Tl(III) in proximity to DNA causes DNA damage. Iodobeads provide a simple, mild method to convert thallium-201 from a 1+ to 3+ oxidation state and [201Tl]Tl(III) can be chelated by DOTA with moderate stability. Of the well-…
View article: A novel toolkit to streamline Land Use Land Cover change assessment in the SWAT+ model to enhance flood management and infrastructure decisions
A novel toolkit to streamline Land Use Land Cover change assessment in the SWAT+ model to enhance flood management and infrastructure decisions Open
<p>Land Use Land Cover (LULC) change is widely recognised as one of the most important factors impacting river basin hydrology.&#160; It is therefore imperative that the hydrological impacts of various LULC changes are considered…
View article: Protocols for Dual Tracer PET/SPECT Preclinical Imaging
Protocols for Dual Tracer PET/SPECT Preclinical Imaging Open
Suitable combinations of injection sequence and imaging sequence can be devised to meet specific experimental multi-tracer imaging needs, with only minor or insignificant effects of each radionuclide on the scan of the other.
View article: CCDC 1563572: Experimental Crystal Structure Determination
CCDC 1563572: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1563570: Experimental Crystal Structure Determination
CCDC 1563570: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1563567: Experimental Crystal Structure Determination
CCDC 1563567: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1563568: Experimental Crystal Structure Determination
CCDC 1563568: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1563566: Experimental Crystal Structure Determination
CCDC 1563566: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1563569: Experimental Crystal Structure Determination
CCDC 1563569: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1563571: Experimental Crystal Structure Determination
CCDC 1563571: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1563574: Experimental Crystal Structure Determination
CCDC 1563574: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1563575: Experimental Crystal Structure Determination
CCDC 1563575: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …