Alex Shimura Yamashita
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View article: Repurposing the anthelmintic drug mebendazole in combination with radiation therapy in an isocitrate dehydrogenase mutant glioma model
Repurposing the anthelmintic drug mebendazole in combination with radiation therapy in an isocitrate dehydrogenase mutant glioma model Open
Background Heterozygous point somatic mutation in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are the most common genetic alterations in malignant glioma. This diffusely infiltrating glioma frequently progresses, despite maximal resec…
View article: ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models
ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models Open
View article: ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models
ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models Open
Pediatric-type high-grade gliomas frequently harbor gene fusions involving receptor tyrosine kinase genes, including neurotrophic tyrosine kinase receptor (NTRK) fusions. Clinically, these tumors show high initial response rates to tyrosin…
View article: Cachexia causes time‐dependent activation of the inflammasome in the liver
Cachexia causes time‐dependent activation of the inflammasome in the liver Open
Background Cachexia is a wasting syndrome associated with systemic inflammation and metabolic disruption. Detection of the early signs of the disease may contribute to the effective attenuation of associated symptoms. Despite playing a cen…
View article: 191. High-Dose Rifampin-containing Regimens for the Treatment of TB Meningitis
191. High-Dose Rifampin-containing Regimens for the Treatment of TB Meningitis Open
Background TB meningitis is the most severe form of tuberculosis (TB), associated with high morbidity and mortality. High-dose rifampin (35mg/kg/day) is safe in adults and substantially improves the bactericidal activity of standard TB reg…
View article: Liver lipid metabolism disruption in cancer cachexia is aggravated by cla supplementation -induced inflammation
Liver lipid metabolism disruption in cancer cachexia is aggravated by cla supplementation -induced inflammation Open
View article: Demethylation and epigenetic modification with 5-azacytidine reduces IDH1 mutant glioma growth in combination with temozolomide
Demethylation and epigenetic modification with 5-azacytidine reduces IDH1 mutant glioma growth in combination with temozolomide Open
5-Aza provided a survival benefit as a single agent but worked best in combination with TMZ in 2 different IDH1 R132H mutant glioma models.
View article: Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors
Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors Open
Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β -cell dysfunction as important hallmarks. Recent evidence indicat…
View article: Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis
Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis Open
View article: mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function
mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function Open
View article: White adipose tissue IFN-γ expression and signalling along the progression of rodent cancer cachexia
White adipose tissue IFN-γ expression and signalling along the progression of rodent cancer cachexia Open
View article: Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice
Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice Open
View article: Doxorubicin caused severe hyperglycaemia and insulin resistance, mediated by inhibition in AMPk signalling in skeletal muscle
Doxorubicin caused severe hyperglycaemia and insulin resistance, mediated by inhibition in AMPk signalling in skeletal muscle Open
Background Cancer is considered the second leading cause of death in the world, and for the treatment of this disease, pharmacological intervention strategies are frequently based on chemotherapy. Doxorubicin (DOX) is one of the most widel…
View article: Aerobic Exercise Modulates the Free Fatty Acids and Inflammatory Response During Obesity and Cancer Cachexia
Aerobic Exercise Modulates the Free Fatty Acids and Inflammatory Response During Obesity and Cancer Cachexia Open
White adipose tissue (WAT) is no longer considered a tissue whose main function is the storage of TAG. Since the discovery of leptin in 1994, several studies have elucidated the important role of WAT as an endocrine organ, the source of th…
View article: White adipose tissue cells and the progression of cachexia: inflammatory pathways
White adipose tissue cells and the progression of cachexia: inflammatory pathways Open
Adipocytes seem to play a relevant role in the establishment of white adipose tissue inflammation, through the activation of the NF-κB and inflammasome pathways. In epididymal adipocytes, induction of the inflammasome may be detected alrea…